Self-supervised pre-training with diffusion model for few-shot landmark detection in x-ray images

In the last few years, deep neural networks have been extensively applied in the medical domain for different tasks, ranging from image classification and segmentation to landmark detection. However, the application of these technologies in the medical domain is often hindered by data scarcity, both in terms of available annotations and images. This study introduces a new self-supervised pre-training protocol based on diffusion models for landmark detection in x-ray images. Our results show that the proposed self-supervised framework can provide accurate landmark detection with a minimal number of available annotated training images (up to 50), outperforming ImageNet supervised pre-training and state-of-the-art self-supervised pre-trainings for three popular x-ray benchmark datasets. To our knowledge, this is the first exploration of diffusion models for self-supervised learning in landmark detection, which may offer a valuable pre-training approach in few-shot regimes, for mitigating data scarcity.