Causal Inference in Case-Control Studies

We investigate partial identification of causal relative and attributable risk---the ratio of two counterfactual proportions and the difference between them---in case-control and case-population studies. The odds ratio is shown to be a sharp upper bound on causal relative risk under the monotone treatment response and monotone treatment selection assumptions, without resorting to strong ignorability, nor to the rare-disease assumption. Sharp bounds on causal attributable risk are also obtained under the same assumptions. Paying special attention to the (conditional) odds ratio, we propose a semiparametrically efficient estimator of the aggregated (log) odds ratio. Further, we develop easy-to-implement causal inference procedures for relative and attributable risk. Finally, we showcase our methodology by applying it to two unique datasets in the literature. We find that attending private school may have little effect on entering a very selective university in Pakistan and that dropping out of school could substantially increase relative and attributable risk of joining a criminal gang in Brazil.