Predicting microRNA-disease associations from knowledge graph using tensor decomposition with relational constraints

Motivation: MiRNAs are a kind of small non - coding RNAs that are not translated into proteins, and aberrant expression of miRNAs is associated with human diseases. Since miRNAs have different roles in diseases, the miRNA - disease associations are categorized into multiple types according to their roles. Predicting miRNA - disease associations and types is critical to understand the underlying patho genesis of human diseases from the molecular level . Results: In this paper, we formulate the problem as a link prediction in knowledge graphs. We use biomedical knowledge bases to build a knowledge graph of entities representing miRNAs and disease and mult i - relations, and we propose a tensor decomposition - based model named TDRC to predict miRNA - disease associations and their types from the knowledge graph. We have experimentally evaluated our method and compared it to several baseline methods. The results d emonstrate that the proposed method h as high - accuracy and high - efficiency performances.