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The Fourth Industrial Revolution, also known as Industry 4.0, represents the technological evolution from traditional manufacturing systems to cyber-physical systems, which leads to improvement of overall productivity and reductions of environmental impact, thus promoting sustainable economic development. Industry 4.0 has been driven by emerging technology developments in the field of digital twin, artificial intelligence, robotic and automation, Internet of Things (IoT), cloud computing, and edge/fog computing, and has been a hot topic in both academia and industry. The resulting big data are fed to AI-based mission-critical systems to perform effectively production monitoring, quality inspection, root cause analysis, quality prediction, and process control. The proper adoption of relevant industry 4.0 technologies should lead to significant efficiency improvement and cost reduction in various industrial sectors. The goal of this special issue is to bring together researchers and practitioners from academia and industry to provide a forum for discussing industrial automation research on smart manufacturing and machine learning.