The VampPrior Mixture Model

These methods analysis by performing integration and clustering are notorious for finding structure where no structure exists simultaneously. We adapt the VampPrior (Tomczak (Chari & Pachter, 2023). When the embedding function & Welling, 2018) into a Dirichlet process does not account for systematic shifts in expression profiling Gaussian mixture model, resulting in the Vamp-between datasets and/or batches that use different scRNAseq Prior Mixture Model (VMM), a novel prior for technologies, misleading structure can arise, confounding DLVMs. We propose an inference procedure that standard analysis pipelines. Accordingly, Lähnemann alternates between variational inference and Empirical et al. (2020) identify atlas-level integration as one of the Bayes to cleanly distinguish variational grand challenges of single-cell data science.