Human Digital Twins in Personalized Healthcare: An Overview and Future Perspectives

This evolution indicates an expansion from industrial uses into diverse fields, including healthcare [61], [59]. The core functionalities of digital twins include an accurate mirroring of their physical counterparts, capturing all associated processes in a data-driven manner, maintaining a continuous connection that synchronizes with the real-time state of their physical twins, and simulating physical behavior for predictive analysis [85]. In the context of healthcare, a novel extension of this technology manifests in the form of Human Digital Twins (HDTs), designed to provide a comprehensive digital mirror of individual patients. HDTs not only represent physical attributes but also integrate dynamic changes across molecular, physiological, and behavioral dimensions. This advancement is aligned with a shift toward personalized healthcare (PH) paradigms, enabling tailored treatment strategies based on a patient's unique health profile, thereby enhancing preventive, diagnostic, and therapeutic processes in clinical settings [44], [50]. The personalization aspect of HDTs underscores their potential to revolutionize healthcare by facilitating precise and individualized treatment plans that optimize patient outcomes [72]. Although the potential of digital twins in healthcare has garnered much attention, practical applications remain newly developing, with critical literature highlighting that many implementations are still in exploratory stages [59]. Notably, institutions like the IEEE Computer Society and Gartner recognize this technology as a pivotal component in the ongoing evolution of healthcare systems that emphasize both precision and personalization [31], [89].