This evolution indicates an expansion from industrial uses into diverse fields, including healthcare [61], [59]. The core functionalities of digital twins include an accurate mirroring of their physical counterparts, capturing all associated processes in a data-driven manner, maintaining a continuous connection that synchronizes with the real-time state of their physical twins, and simulating physical behavior for predictive analysis [85]. In the context of healthcare, a novel extension of this technology manifests in the form of Human Digital Twins (HDTs), designed to provide a comprehensive digital mirror of individual patients. HDTs not only represent physical attributes but also integrate dynamic changes across molecular, physiological, and behavioral dimensions. This advancement is aligned with a shift toward personalized healthcare (PH) paradigms, enabling tailored treatment strategies based on a patient's unique health profile, thereby enhancing preventive, diagnostic, and therapeutic processes in clinical settings [44], [50]. The personalization aspect of HDTs underscores their potential to revolutionize healthcare by facilitating precise and individualized treatment plans that optimize patient outcomes [72]. Although the potential of digital twins in healthcare has garnered much attention, practical applications remain newly developing, with critical literature highlighting that many implementations are still in exploratory stages [59]. Notably, institutions like the IEEE Computer Society and Gartner recognize this technology as a pivotal component in the ongoing evolution of healthcare systems that emphasize both precision and personalization [31], [89].

As the field of data analysis grows rapidly due to the large amounts The Rule Aggregating ClassifiER (RACER) [7] is a rule-based of data being generated, effective data classification has become increasingly classification algorithm that generates initial rules from training important. This paper introduces the RUle Mutation Classifier dataset records with the same mechanism. However, these rules (RUMC), which represents a significant improvement over the tend to be too specific, making them less effective for classifying Rule Aggregation ClassifiER (RACER). RUMC uses innovative rule new data, particularly when working with small datasets that have mutation techniques based on evolutionary methods to improve few distinct instances. To address this challenge, I introduce the classification accuracy. In tests with forty datasets from OpenML RUle Mutation Classifier (RUMC), a novel algorithm that enhances and the UCI Machine Learning Repository, RUMC consistently outperformed the capabilities of RACER. RUMC aims to improve the handling of twenty other well-known classifiers, demonstrating its various datasets, including high-dimensional and low-sample-size ability to uncover valuable insights from complex data.

The Web is a vast virtual space where people can share their opinions, impacting all aspects of life and having implications for marketing and communication. The most up-to-date and comprehensive information can be found on social media because of how widespread and straightforward it is to post a message. Proportionately, they are regarded as a valuable resource for making precise market predictions. In particular, Twitter has developed into a potent tool for understanding user sentiment. This article examines how well tweets can influence stock symbol trends. We analyze the volume, sentiment, and mentions of the top five stock symbols in the S&P 500 index on Twitter over three months. Long Short-Term Memory, Bernoulli Na\"ive Bayes, and Random Forest were the three algorithms implemented in this process. Our study revealed a significant correlation between stock prices and Twitter sentiment.