AlphaFold Changed Science. After 5 Years, It's Still Evolving

WIRED spoke with DeepMind's Pushmeet Kohli about the recent past--and promising future--of the Nobel Prize-winning research project that changed biology and chemistry forever. Amino acids "folded" to form a protein. Over the past few years, we've periodically reported on its successes; last year, it won the Nobel Prize in Chemistry . Until AlphaFold's debut in November 2020, DeepMind had been best known for teaching an artificial intelligence to beat human champions at the ancient game of Go Its work culminated in the compilation of a database that now contains over 200 million predicted structures, essentially the entire known protein universe, and is used by nearly 3.5 million researchers in 190 countries around the world The Nature article published in 2021 describing the algorithm has been cited 40,000 times to date. Last year, AlphaFold 3 arrived, extending the capabilities of artificial intelligence to DNA, RNA, and drugs.