Drosophila Gene Expression Pattern Annotation through Multi-Instance Multi-Label Learning

The Berkeley Drosophila Genome Project (BDGP) has produced a large number of gene expression patterns, many of which have been annotated textually with anatomical and developmental terms. These terms spatially correspond to local regions of the images; however, they are attached collectively to groups of images, such that it is unknown which term is assigned to which region of which image in the group. This poses a challenge to the development of the computational method to automate the textual description of expression patterns contained in each image. In this paper, we show that the underlying nature of this task matches well with Figure 1: Samples of images and associated annotation terms a new machine learning framework, Multi-Instance of the gene Actn in the stage ranges 11-12 and 13-16 in the Multi-Label learning (MIML). We propose a new BDGP database. The darkly stained region highlights the MIML support vector machine to solve the problems place where the gene is expressed. The darker the region, that beset the annotation task.