ConDiSim: Conditional Diffusion Models for Simulation Based Inference

Statistical inference of model parameters from empirical observations is a fundamental challenge in scientific research, enabling researchers to derive meaningful insights from complex simulation models. These parameters govern the behavior of simulators that replicate real-world phenomena, providing a bridge between theoretical constructs and empirical observations [Lavin et al., 2021]. Calibrating these parameters to ensure that simulator outputs align with observed data constitutes an inverse problem, formally defined within the framework of simulation-based inference (SBI) [Cranmer et al., 2020]. Solving this inverse problem involves addressing uncertainties arising from model stochasticity and potential multi-valuedness, where different sets of parameter values can produce similar observations or similar parameters may lead to varied outputs. Additionally, parameter inference becomes increasingly complex when simulators operate as'black boxes' with intractable likelihood functions, rendering traditional likelihood-based Bayesian methods impractical [Sisson et al., 2018].