Communication-Efficient Integrative Regression in High-Dimensions

We consider the task of meta-analysis in high-dimensional settings in which the data sources we wish to integrate are similar but non-identical. To borrow strength across such heterogeneous data sources, we introduce a global parameter that addresses several identification issues. We also propose a one-shot estimator of the global parameter that preserves the anonymity of the data sources and converges at a rate that depends on the size of the combined dataset. Finally, we demonstrate the benefits of our approach on a large-scale drug treatment dataset involving several different cancer cell lines.