Using Large Language Models to Generate Clinical Trial Tables and Figures

Tables, figures, and listings (TFLs) are essential tools for summarizing clinical trial data. Creation of TFLs for reporting activities is often a time-consuming task encountered routinely during the execution of clinical trials. This study explored the use of large language models (LLMs) to automate the generation of TFLs through prompt engineering and few-shot transfer learning. Using public clinical trial data in ADaM format, our results demonstrated that LLMs can efficiently generate TFLs with prompt instructions, showcasing their potential in this domain. Furthermore, we developed a conservational agent named "Clinical Trial TFL Generation Agent": An app that matches user queries to predefined prompts that produce customized programs to generate specific pre-defined TFLs. 1 Introduction In the pharmaceutical industry, submission of a clinical study report (CSR) is part of the drug approval process with health authorities.