Simple Agents Outperform Experts in Biomedical Imaging Workflow Optimization

Adapting production-level computer vision tools to bespoke scientific datasets is a critical "last mile" bottleneck. Current solutions are impractical: fine-tuning requires large annotated datasets scientists often lack, while manual code adaptation costs scientists weeks to months of effort. W e consider using AI agents to automate this manual coding, and focus on the open question of optimal agent design for this targeted task. W e introduce a systematic evaluation framework for agentic code optimization and use it to study three production-level biomedical imaging pipelines. W e demonstrate that a simple agent framework consistently generates adaptation code that outperforms human-expert solutions. Our analysis reveals that common, complex agent architectures are not universally beneficial, leading to a practical roadmap for agent design.