Revolutionizing Clinical Trials: A Manifesto for AI-Driven Transformation

Clinical trials are the bedrock of medical practice. They provide a scientifically rigorous way to test the safety and efficacy of new treatments, drugs, and medical devices. Considering the substantial investment required for clinical trials, with Phase III trials often exceeding $500 million and lasting several years [Sertkaya et al., 2024], it is crucial to conduct them with utmost efficiency. Furthermore, they represent a cornerstone in the pharmaceutical industry's ongoing commitment to enhancing patient care strategies. To inform evidence-based practice, trials should accurately represent the diversity and complexity of real-world patient populations, thereby strengthening the evidence for new treatments.