Designing Interpretable ML System to Enhance Trustworthy AI in Healthcare: A Systematic Review of the Last Decade to A Proposed Robust Framework

AI-based medical technologies, including wearables, telemedicine, LLMs, and digital care twins, significantly impact healthcare. Ensuring AI results are accurate and interpretable is crucial, especially for clinicians. This paper reviews processes and challenges of interpretable ML (IML) and explainable AI (XAI) in healthcare. Objectives include reviewing XAI processes, methods, applications, and challenges, with a focus on quality control. The IML process is classified into data pre-processing interpretability, interpretable modeling, and post-processing interpretability. The paper aims to establish the importance of robust interpretability in healthcare through experimental results, providing insights for creating communicable clinician-AI tools. Research questions, eligibility criteria, and goals were identified following PRISMA and PICO methods. PubMed, Scopus, and Web of Science were systematically searched using specific strings. The survey introduces a step-by-step roadmap for implementing XAI in clinical applications, addressing existing gaps and acknowledging XAI model limitations.