MRI correlates of chronic symptoms in mild traumatic brain injury

Some veterans with a history of mild traumatic brain injury (mTBI) have reported experiencing auditory and visual dysfunction that persist beyond the acute phase of the incident. The etiology behind th ese symptoms is difficult to characterize, since mTBI is defined by negative imaging findings on current clinical imaging. There are several competing hypotheses that could explain functional deficits; one example is shear inju ry, which may manifest in dif fusion - weighted magnetic resonance (MR) imaging (DWI) . Herein, we explore this alternative hypothe sis in a pilot study of multi - parametric MR imaging. Briefly, we consider a cohort of 8 mTBI patients relative to 22 control subjects using structural T1 - weig hted imaging (T1w) and connectivity with DWI.