The use of computers in chemistry and biochemistry has been widespread for many years, with machines performing many complex numerical calculations, e.g.

Our understanding of any process can be measured by the extent to which a simulation we create mimics the real behavior of that process. Deviations of a simulation indicate either limitations or errors in our knowledge. In addition, these observed differences often suggest verifiable experimental hypotheses to extend our knowledge. The biochemical approach to understanding biological processes is essentially one of simulation. A biochemist typically prepares a cell-free extract that can mediate a well-described physiological process. The extract is then fractionated to purify the components that catalyze individual reactions.

Cohen, Design Considerations for a Program to Provide Consultations in Clinical Therapeutics, in Proceedings of San Diego Biomedical Symposium, February 1974.

Cohen, Design Considerations for a Program to Provide Consultations in Clinical Therapeutics, in Proceedings of San Diego Biomedical Symposium, February 1974.

Shortly after Watson and Crick's discovery of the structure of DNA, and at about the same time that the genetic code and the essential facts of gene expression were being elucidated, the field of linguistics was being similarly revolutionized by the work of Noam Chomsky [Chomsky, 1955, 1957, 1959, 1963, 1965]. Observing that a seemingly infinite variety of language was available to individual human beings based on clearly finite resources and experience, he proposed a formal representation of the rules or syntax of language, called generative grammar, that could provide finite--indeed, concise--characterizations of such infinite languages. Just as the breakthroughs in molecular biology in that era served to anchor genetic concepts in physical structures and opened up entirely novel experimental paradigms, so did Chomsky's insight serve to energize the field of linguistics, with putative correlates of cognitive processes that could for the first time be reasoned about 48 A

Case-based reasoning is used extensively by people in A second driving force in the evolutionary history of CBR both expert and commonsense situations. It provides a was dissatisfaction with rule-based reasoning (expert systems wide range of advantages.

When working from of a small set of primitives and the statement of a such representations, lexical choice is often a nonissue program's knowledge as a set of expressions over these since each term can be uniquely associated with a natural primitives plus a set of constant terms for individuals.

Empirical rule learning and analytic Most learning is based on experience, and this requires a learning methods have predominantly used the first path, representation for the experiential input given to the whereas connectionist systems have relied on the second.

An early expression of this difficulty is the socalled might be stated that Socrates's birthplace was Athens.

Current research has succeeded in despite much work attempting to do so, human-- exploring a large number of domains and has explored machine communication is not yet sensitive to dialogue some nontraditional pedagogical strategies, such as partnering, context and to what is known or knowable about the student's mentoring, and scaffolding.