While `jailbreaks' have been central to research on the safety and reliability of LLMs (large language models), the underlying mechanisms behind these attacks are not well understood. Some prior works have used linear methods to analyze jailbreak prompts or model refusal. Here, however, we compare linear and nonlinear methods to study the features in prompts that contribute to successful jailbreaks. We do this by probing for jailbreak success based only on the portions of the latent representations corresponding to prompt tokens. First, we introduce a dataset of 10,800 jailbreak attempts from 35 attack methods. We then show that different jailbreaking methods work via different nonlinear features in prompts. Specifically, we find that while probes can distinguish between successful and unsuccessful jailbreaking prompts with a high degree of accuracy, they often transfer poorly to held-out attack methods. We also show that nonlinear probes can be used to mechanistically jailbreak the LLM by guiding the design of adversarial latent perturbations. These mechanistic jailbreaks are able to jailbreak Gemma-7B-IT more reliably than 34 of the 35 techniques that it was trained on. Ultimately, our results suggest that jailbreaks cannot be thoroughly understood in terms of universal or linear prompt features alone.

Bridging biomolecular modeling with natural language information, particularly through large language models (LLMs), has recently emerged as a promising interdisciplinary research area. LLMs, having been trained on large corpora of scientific documents, demonstrate significant potential in understanding and reasoning about biomolecules by providing enriched contextual and domain knowledge. However, the extent to which LLM-driven insights can improve performance on complex predictive tasks (e.g., toxicity) remains unclear. Further, the extent to which relevant knowledge can be extracted from LLMs also remains unknown. In this study, we present Molecule Caption Arena: the first comprehensive benchmark of LLM-augmented molecular property prediction. We evaluate over twenty LLMs, including both general-purpose and domain-specific molecule captioners, across diverse prediction tasks. To this goal, we introduce a novel, battle-based rating system. Our findings confirm the ability of LLM-extracted knowledge to enhance state-of-the-art molecular representations, with notable model-, prompt-, and dataset-specific variations. Code, resources, and data are available at github.com/Genentech/molcap-arena.

Microrobots engineered from self-propelling active particles, extend the reach of robotic operations to submillimeter dimensions and are becoming increasingly relevant for various tasks, such as manipulation of micro/nanoscale cargo, particularly targeted drug delivery. However, achieving deep-tissue penetration and drug delivery remain a challenge. This work developed a novel biohybrid microrobot consisting of jellyfish stinging capsules, which act as natural nanoinjectors for efficient penetration and delivery, assembled onto an active Janus particle (JP). While microrobot transport and navigation was externally controlled by magnetic field-induced rolling, capsule loading onto the JP surface was controlled by electric field. Following precise navigation of the biohybrid microrobots to the vicinity of target tissues, the capsules were activated by a specific enzyme introduced to the solution, which then triggered tubule ejection and release of the preloaded molecules. Use of such microrobots for penetration of and delivery of the preloaded drug/toxin to targeted cancer spheroids and live Caenorhabditis elegans was demonstrated in-vitro. The findings offer insights for future development of bio-inspired microrobots capable of deep penetration and drug delivery. Future directions may involve encapsulation of various drugs within different capsule types for enhanced versatility. This study may also inspire in-vivo applications involving deep tissue drug delivery.

Recent development in Artificial Intelligence (AI) models has propelled their application in scientific discovery, but the validation and exploration of these discoveries require subsequent empirical experimentation. The concept of self-driving laboratories promises to automate and thus boost the experimental process following AI-driven discoveries. However, the transition of experimental protocols, originally crafted for human comprehension, into formats interpretable by machines presents significant challenges, which, within the context of specific expert domain, encompass the necessity for structured as opposed to natural language, the imperative for explicit rather than tacit knowledge, and the preservation of causality and consistency throughout protocol steps. Presently, the task of protocol translation predominantly requires the manual and labor-intensive involvement of domain experts and information technology specialists, rendering the process time-intensive. To address these issues, we propose a framework that automates the protocol translation process through a three-stage workflow, which incrementally constructs Protocol Dependence Graphs (PDGs) that approach structured on the syntax level, completed on the semantics level, and linked on the execution level. Quantitative and qualitative evaluations have demonstrated its performance at par with that of human experts, underscoring its potential to significantly expedite and democratize the process of scientific discovery by elevating the automation capabilities within self-driving laboratories.

Deep Learning methods are notorious for relying on extensive labeled datasets to train and assess their performance. This can cause difficulties in practical situations where models should be trained for new applications for which very little data is available. While few-shot learning algorithms can address the first problem, they still lack sufficient explanations for the results. This research presents a workflow that tackles both challenges by proposing an explainable few-shot learning workflow for detecting invasive and exotic tree species in the Atlantic Forest of Brazil using Unmanned Aerial Vehicle (UAV) images. By integrating a Siamese network with explainable AI (XAI), the workflow enables the classification of tree species with minimal labeled data while providing visual, case-based explanations for the predictions. Results demonstrate the effectiveness of the proposed workflow in identifying new tree species, even in data-scarce conditions. With a lightweight backbone, e.g., MobileNet, it achieves a F1-score of 0.86 in 3-shot learning, outperforming a shallow CNN. A set of explanation metrics, i.e., correctness, continuity, and contrastivity, accompanied by visual cases, provide further insights about the prediction results. This approach opens new avenues for using AI and UAVs in forest management and biodiversity conservation, particularly concerning rare or under-studied species.

Additive Manufacturing (AM) is transforming the manufacturing sector by enabling efficient production of intricately designed products and small-batch components. However, metal parts produced via AM can include flaws that cause inferior mechanical properties, including reduced fatigue response, yield strength, and fracture toughness. To address this issue, we leverage convolutional neural networks (CNN) to analyze thermal images of printed layers, automatically identifying anomalies that impact these properties. We also investigate various synthetic data generation techniques to address limited and imbalanced AM training data. Our models' defect detection capabilities were assessed using images of Nickel alloy 718 layers produced on a laser powder bed fusion AM machine and synthetic datasets with and without added noise. Our results show significant accuracy improvements with synthetic data, emphasizing the importance of expanding training sets for reliable defect detection. Specifically, Generative Adversarial Networks (GAN)-generated datasets streamlined data preparation by eliminating human intervention while maintaining high performance, thereby enhancing defect detection capabilities. Additionally, our denoising approach effectively improves image quality, ensuring reliable defect detection. Finally, our work integrates these models in the CLoud ADditive MAnufacturing (CLADMA) module, a user-friendly interface, to enhance their accessibility and practicality for AM applications. This integration supports broader adoption and practical implementation of advanced defect detection in AM processes.

Accurate prediction of Global Warming Potential (GWP) is essential for assessing the environmental impact of chemical processes and materials. Traditional GWP prediction models rely predominantly on molecular structure, overlooking critical process-related information. In this study, we present an integrative GWP prediction model that combines molecular descriptors (MACCS keys and Mordred descriptors) with process information (process title, description, and location) to improve predictive accuracy and interpretability. Using a deep neural network (DNN) model, we achieved an R-squared of 86% on test data with Mordred descriptors, process location, and description information, representing a 25% improvement over the previous benchmark of 61%; XAI analysis further highlighted the significant role of process title embeddings in enhancing model predictions. To enhance interpretability, we employed a Kolmogorov-Arnold Network (KAN) to derive a symbolic formula for GWP prediction, capturing key molecular and process features and providing a transparent, interpretable alternative to black-box models, enabling users to gain insights into the molecular and process factors influencing GWP. Error analysis showed that the model performs reliably in densely populated data ranges, with increased uncertainty for higher GWP values. This analysis allows users to manage prediction uncertainty effectively, supporting data-driven decision-making in chemical and process design. Our results suggest that integrating both molecular and process-level information in GWP prediction models yields substantial gains in accuracy and interpretability, offering a valuable tool for sustainability assessments. Future work may extend this approach to additional environmental impact categories and refine the model to further enhance its predictive reliability.

Decision Transformers have recently emerged as a new and compelling paradigm for offline Reinforcement Learning (RL), completing a trajectory in an autoregressive way. While improvements have been made to overcome initial shortcomings, online finetuning of decision transformers has been surprisingly under-explored. The widely adopted state-of-the-art Online Decision Transformer (ODT) still struggles when pretrained with low-reward offline data. In this paper, we theoretically analyze the online-finetuning of the decision transformer, showing that the commonly used Return-To-Go (RTG) that's far from the expected return hampers the online fine-tuning process. This problem, however, is well-addressed by the value function and advantage of standard RL algorithms. As suggested by our analysis, in our experiments, we hence find that simply adding TD3 gradients to the finetuning process of ODT effectively improves the online finetuning performance of ODT, especially if ODT is pretrained with low-reward offline data. These findings provide new directions to further improve decision transformers.

AI agents have been evaluated in isolation or within small groups, where interactions remain limited in scope and complexity. Large-scale simulations involving many autonomous agents -- reflecting the full spectrum of civilizational processes -- have yet to be explored. Here, we demonstrate how 10 - 1000+ AI agents behave and progress within agent societies. We first introduce the PIANO (Parallel Information Aggregation via Neural Orchestration) architecture, which enables agents to interact with humans and other agents in real-time while maintaining coherence across multiple output streams. We then evaluate agent performance in agent simulations using civilizational benchmarks inspired by human history. These simulations, set within a Minecraft environment, reveal that agents are capable of meaningful progress -- autonomously developing specialized roles, adhering to and changing collective rules, and engaging in cultural and religious transmission. These preliminary results show that agents can achieve significant milestones towards AI civilizations, opening new avenues for large simulations, agentic organizational intelligence, and integrating AI into human civilizations.

Process mining gains increasing popularity in business process analysis, also in heavy industry. It requires a specific data format called an event log, with the basic structure including a case identifier (case ID), activity (event) name, and timestamp. In the case of industrial processes, data is very often provided by a monitoring system as time series of low level sensor readings. This data cannot be directly used for process mining since there is no explicit marking of activities in the event log, and sometimes, case ID is not provided. We propose a novel rule-based algorithm for identification patterns, based on the identification of significant changes in short-term mean values of selected variable to detect case ID. We present our solution on the mining use case. We compare computed results (identified patterns) with expert labels of the same dataset. Experiments show that the developed algorithm in the most of the cases correctly detects IDs in datasets with and without outliers reaching F1 score values: 96.8% and 97% respectively. We also evaluate our algorithm on dataset from manufacturing domain reaching value 92.6% for F1 score.