AI chatbots miss urgent issues in queries about women's health AI models such as ChatGPT and Gemini fail to give adequate advice for 60 per cent of queries relating to women's health in a test created by medical professionals Many women are using AI for health information, but the answers aren't always up to scratch Commonly used AI models fail to accurately diagnose or offer advice for many queries relating to women's health that require urgent attention. Thirteen large language models, produced by the likes of OpenAI, Google, Anthropic, Mistral AI and xAI, were given 345 medical queries across five specialities, including emergency medicine, gynaecology and neurology. The queries were written by 17 women's health researchers, pharmacists and clinicians from the US and Europe. The answers were reviewed by the same experts. Any questions that the models failed at were collated into a benchmarking test of AI models' medical expertise that included 96 queries.

Discharge summaries in Electronic Health Records (EHRs) are crucial for clinical decision-making, but their length and complexity make information extraction challenging, especially when dealing with accumulated summaries across multiple patient admissions.

Significant effort has been placed on developing decision support tools to improve patient care. However, drivers of real-world clinical decisions in complex medical scenarios are not yet well-understood, resulting in substantial gaps between these tools and practical applications. In light of this, we highlight that more attention on understanding clinical decision-making is required both to elucidate current clinical practices and to enable effective human-machine interactions. This is imperative in high-stakes scenarios with scarce available resources.

AI based mental health diagnosis is often judged by benchmark accuracy, yet in practice its value depends on how psychologists respond whether they accept, adjust, or reject AI suggestions. Mental health makes this especially challenging: decisions are continuous and shaped by cues in tone, pauses, word choice, and nonverbal behaviors of patients. Current research rarely examines how AI diagnosis interface design influences these choices, leaving little basis for reliable testing before live studies. We present SimClinician, an interactive simulation platform, to transform patient data into psychologist AI collaborative diagnosis. Contributions include: (1) a dashboard integrating audio, text, and gaze-expression patterns; (2) an avatar module rendering de-identified dynamics for analysis; (3) a decision layer that maps AI outputs to multimodal evidence, letting psychologists review AI reasoning, and enter a diagnosis. Tested on the E-DAIC corpus (276 clinical interviews, expanded to 480,000 simulations), SimClinician shows that a confirmation step raises acceptance by 23%, keeping escalations below 9%, and maintaining smooth interaction flow.

Background: Mentalization integrates cognitive, affective, and intersubjective components. Large Language Models (LLMs) display an increasing ability to generate reflective texts, raising questions regarding the relationship between linguistic form and mental representation. This study assesses the extent to which a single LLM can reproduce the linguistic structure of mentalization according to the parameters of Mentalization-Based Treatment (MBT). Methods: Fifty dialogues were generated between human participants and an LLM configured in standard mode. Five psychiatrists trained in MBT, working under blinded conditions, evaluated the mentalization profiles produced by the model along the four MBT axes, assigning Likert-scale scores for evaluative coherence, argumentative coherence, and global quality. Inter-rater agreement was estimated using ICC(3,1). Results: Mean scores (3.63-3.98) and moderate standard deviations indicate a high level of structural coherence in the generated profiles. ICC values (0.60-0.84) show substantial-to-high agreement among raters. The model proved more stable in the Implicit-Explicit and Self-Other dimensions, while presenting limitations in the integration of internal states and external contexts. The profiles were coherent and clinically interpretable yet characterized by affective neutrality.

AI-assisted gait analysis holds promise for improving Parkinson's Disease (PD) care, but current clinical dashboards lack transparency and offer no meaningful way for clinicians to interrogate or contest AI decisions. To address this issue, we present Motion2Meaning, a clinician-centered framework that advances Contestable AI through a tightly integrated interface designed for interpretability, oversight, and procedural recourse. Our approach leverages vertical Ground Reaction Force (vGRF) time-series data from wearable sensors as an objective biomarker of PD motor states. The system comprises three key components: a Gait Data Visualization Interface (GDVI), a one-dimensional Convolutional Neural Network (1D-CNN) that predicts Hoehn & Yahr severity stages, and a Contestable Interpretation Interface (CII) that combines our novel Cross-Modal Explanation Discrepancy (XMED) safeguard with a contestable Large Language Model (LLM). Our 1D-CNN achieves 89.0% F1-score on the public PhysioNet gait dataset. XMED successfully identifies model unreliability by detecting a five-fold increase in explanation discrepancies in incorrect predictions (7.45%) compared to correct ones (1.56%), while our LLM-powered interface enables clinicians to validate correct predictions and successfully contest a portion of the model's errors. A human-centered evaluation of this contestable interface reveals a crucial trade-off between the LLM's factual grounding and its readability and responsiveness to clinical feedback. This work demonstrates the feasibility of combining wearable sensor analysis with Explainable AI (XAI) and contestable LLMs to create a transparent, auditable system for PD gait interpretation that maintains clinical oversight while leveraging advanced AI capabilities. Our implementation is publicly available at: https://github.com/hungdothanh/motion2meaning.

Clinical communication is central to patient outcomes, yet large-scale human annotation of patient-provider conversation remains labor-intensive, inconsistent, and difficult to scale. Existing approaches based on large language models typically rely on single-task models that lack adaptability, interpretability, and reliability, especially when applied across various communication frameworks and clinical domains. In this study, we developed a Multi-framework Structured Agentic AI system for Clinical Communication (MOSAIC), built on a LangGraph-based architecture that orchestrates four core agents, including a Plan Agent for codebook selection and workflow planning, an Update Agent for maintaining up-to-date retrieval databases, a set of Annotation Agents that applies codebook-guided retrieval-augmented generation (RAG) with dynamic few-shot prompting, and a Verification Agent that provides consistency checks and feedback. To evaluate performance, we compared MOSAIC outputs against gold-standard annotations created by trained human coders. We developed and evaluated MOSAIC using 26 gold standard annotated transcripts for training and 50 transcripts for testing, spanning rheumatology and OB/GYN domains. On the test set, MOSAIC achieved an overall F1 score of 0.928. Performance was highest in the Rheumatology subset (F1 = 0.962) and strongest for Patient Behavior (e.g., patients asking questions, expressing preferences, or showing assertiveness). Ablations revealed that MOSAIC outperforms baseline benchmarking.

Digital health interventions increasingly deliver home exercise programs via sensor-equipped devices such as smartphones, enabling remote monitoring of adherence and performance. However, current software is usually authored before clinical encounters as libraries of modules for broad impairment categories. At the point of care, clinicians can only choose from these modules and adjust a few parameters (for example, duration or repetitions). As a result, individual limitations, goals, and environmental constraints are often not reflected, limiting personalization and benefit. We propose a paradigm in which large language models (LLMs) act as constrained translators that convert clinicians' exercise prescriptions into intervention software. Clinicians remain the decision makers: they design exercises during the encounter, tailored to each patient's impairments, goals, and environment, and the LLM generates matching software. We conducted a prospective single-arm feasibility study with 20 licensed physical and occupational therapists who created 40 individualized upper extremity programs for a standardized patient; 100% of prescriptions were translated into executable software, compared with 55% under a representative template-based digital health intervention (p < 0.01). LLM-generated software correctly delivered 99.7% of instructions and monitored performance with 88.4% accuracy (95% confidence interval, 0.843-0.915). Overall, 90% of therapists judged the system safe for patient interaction and 75% expressed willingness to adopt it in practice. To our knowledge, this is the first prospective evaluation of clinician-directed intervention software generation with an LLM in health care, demonstrating feasibility and motivating larger trials in real patient populations.

This paper presents the design and implementation of an Extended Reality (XR) platform for immersive, interactive visualization of Electronic Health Records (EHRs). The system extends beyond conventional 2D interfaces by visualizing both structured and unstructured patient data into a shared 3D environment, enabling intuitive exploration and real-time collaboration. The modular infrastructure integrates FHIR-based EHR data with volumetric medical imaging and AI-generated segmentation, ensuring interoperability with modern healthcare systems. The platform's capabilities are demonstrated using synthetic EHR datasets and computed tomography (CT)-derived spine models processed through an AI-powered segmentation pipeline. This work suggests that such integrated XR solutions could form the foundation for next-generation clinical decision-support tools, where advanced data infrastructures are directly accessible in an interactive and spatially rich environment.

Recent advances in psychotherapy have focused on treatment personalization, such as by selecting treatment modules based on personalized networks. However, estimating personalized networks typically requires intensive longitudinal data, which is not always feasible. A solution to facilitate scalability of network-driven treatment personalization is leveraging LLMs. In this study, we present an end-to-end pipeline for automatically generating client networks from 77 therapy transcripts to support case conceptualization and treatment planning. We annotated 3364 psychological processes and their corresponding dimensions in therapy transcripts. Using these data, we applied in-context learning to jointly identify psychological processes and their dimensions. The method achieved high performance even with a few training examples. To organize the processes into networks, we introduced a two-step method that grouped them into clinically meaningful clusters. We then generated explanation-augmented relationships between clusters. Experts found that networks produced by our multi-step approach outperformed those built with direct prompting for clinical utility and interpretability, with up to 90% preferring our approach. In addition, the networks were rated favorably by experts, with scores for clinical relevance, novelty, and usefulness ranging from 72-75%. Our findings provide a proof of concept for using LLMs to create clinically relevant networks from therapy transcripts. Advantages of our approach include bottom-up case conceptualization from client utterances in therapy sessions and identification of latent themes. Networks generated from our pipeline may be used in clinical settings and supervision and training. Future research should examine whether these networks improve treatment outcomes relative to other methods of treatment personalization, including statistically estimated networks.