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Validating the Clinical Utility of CineECG 3D Reconstructions through Cross-Modal Feature Attribution

arXiv.org Machine Learning

Deep learning models for 12-lead electrocardiogram (ECG) analysis achieve high diagnostic performance but lack the intuitive interpretability required for clinical integration. Standard feature attribution methods are limited by the inherent difficulty in mapping abstract waveform fluctuations to physical anatomical pathologies. To resolve this, we propose a cross-modal method that projects feature attributions from high-performance 12-lead ECG models onto the CineECG 3D anatomical space. Our study reveals that while models trained directly on CineECG signals suffer from reduced accuracy and incoherent attributions, the proposed mapping mechanism effectively recovers clinically relevant feature rankings. Validated against a ground-truth dataset of 20 cases annotated by domain experts, the mapped explanations yield a Dice score of 0.56, significantly outperforming the 0.47 baseline of standard 12-lead attributions. These findings indicate that cross-modal averaging mapping effectively filters attribution instability and improves the localization of pathological features, combining the diagnostic expressiveness of standard ECG with the intuitive clarity of anatomical visualization.



EHRNoteQA: An LLM Benchmark for Real-World Clinical Practice Using Discharge Summaries

Neural Information Processing Systems

Discharge summaries in Electronic Health Records (EHRs) are crucial for clinical decision-making, but their length and complexity make information extraction challenging, especially when dealing with accumulated summaries across multiple patient admissions.



GV-Rep: A Large-Scale Dataset for Genetic Variant Representation Learning

Neural Information Processing Systems

The development of deep learning approaches for modeling these multifactorial effects of GVs is still in its nascent stages, primarily due to the lack of comprehensive datasets that capture the intricate relationships between GVs and their downstream effects on complex traits.






SupplementaryMaterial: ExplainingLatent RepresentationswithaCorpusofExamples

Neural Information Processing Systems

This algorithm approximates the integral involvedinthe definition ofthe Projected Jacobian with a standard Riemann sum. Note that the definition ofX0 implies that the baseline vectorx0 is broadcasted alongthefirstdimension ofthematrix.