Neuronal Fiber Delineation in Area of Edema from Diffusion Weighted MRI

Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) is a non invasive methodfor brain neuronal fibers delineation. Here we show a modification forDT-MRI that allows delineation of neuronal fibers which are infiltrated by edema. We use the Muliple Tensor Variational (MTV) framework which replaces the diffusion model of DT-MRI with a multiple componentmodel and fits it to the signal attenuation with a variational regularizationmechanism. In order to reduce free water contamination weestimate the free water compartment volume fraction in each voxel, remove it, and then calculate the anisotropy of the remaining compartment.