Fast, stealthy, and cheap--autonomous, semisubmersible drone boats carrying tons of cocaine could be international law enforcement's nightmare scenario. A big one just came ashore. Colombian military officials intercepted this 40-foot-long uncrewed fiberglass "narco sub" in the ocean just off Tayrona National Park. On a bright morning last April, a surveillance plane operated by the Colombian military spotted a 40-foot-long shark-like silhouette idling in the ocean just off Tayrona National Park. It was, unmistakably, a "narco sub," a stealthy fiberglass vessel that sails with its hull almost entirely underwater, used by drug cartels to move cocaine north. The plane's crew radioed it in, and eventually nearby coast guard boats got the order, routine but urgent: Intercept. In Cartagena, about 150 miles from the action, Captain Jaime González Zamudio, commander of the regional coast guard group, sat down at his desk to watch what happened next.

Recent progress in the development of voltage indicators [1-8] has brought us closer to a longstanding goal incellular neuroscience: imaging the full spatiotemporal voltageonadendritic tree. These recordings have the potential (pun not intended) to resolve fundamental questions about the computations performed by dendrites -- questions that have remained open for more than a century[9,10].

Neural Information Processing Systems http://nips.cc/

Modern recording techniques now allow us to record from distinct neuronal populations in different brain networks.

Here we give a general decription of the model. Complete versions of the dendritic update rules (summarised in Eqns (2) & (3)) are given below. The notation we're using admits the possible presence of biases as well as the weights (though biases typically aren't's could be added to the synaptic inputs effectively absorbing a We update the layers from bottom to top: first we update the latent or "environment" and increment Learning rules are conceptually summarised by the equations given in the main text, Eqn (6). If the prediction error and one of the presynaptic inputs are both consistently large (i.e. over a We add synaptic noise to the dendritic activations. Hz in order that noise is relatively slow and weak.

Quantitative Systems Pharmacology (QSP) modeling is essential for drug development but it requires significant time investment that limits the throughput of domain experts. We present \textbf{GRASP} -- a multi-agent, graph-reasoning framework with a human-in-the-loop conversational interface -- that encodes QSP models as typed biological knowledge graphs and compiles them to executable MATLAB/SimBiology code while preserving units, mass balance, and physiological constraints. A two-phase workflow -- \textsc{Understanding} (graph reconstruction of legacy code) and \textsc{Action} (constraint-checked, language-driven modification) -- is orchestrated by a state machine with iterative validation. GRASP performs breadth-first parameter-alignment around new entities to surface dependent quantities and propose biologically plausible defaults, and it runs automatic execution/diagnostics until convergence. In head-to-head evaluations using LLM-as-judge, GRASP outperforms SME-guided CoT and ToT baselines across biological plausibility, mathematical correctness, structural fidelity, and code quality (\(\approx\)9--10/10 vs.\ 5--7/10). BFS alignment achieves F1 = 0.95 for dependency discovery, units, and range. These results demonstrate that graph-structured, agentic workflows can make QSP model development both accessible and rigorous, enabling domain experts to specify mechanisms in natural language without sacrificing biomedical fidelity.