Can We Program Our Cells?

Making living cells blink fluorescently like party lights may sound frivolous. But the demonstration that it's possible could be a step toward someday programming our body's immune cells to attack cancers more effectively and safely. That's the promise of the field called synthetic biology. While molecular biologists strip cells down to their component genes and molecules to see how they work, synthetic biologists tinker with cells to get them to perform new feats -- discovering new secrets about how life works in the process. Listen on Apple Podcasts, Spotify, Google Podcasts, Stitcher, TuneIn or your favorite podcasting app, or you can stream it from Quanta. Steve Strogatz (00:03): I'm Steve Strogatz, and this is The Joy of Why, a podcast from Quanta Magazine that takes you into some of the biggest unanswered questions in science and math today. In this episode, we're going to be talking about synthetic biology. Simply put, we could say that synthetic biology is a fusion of biology, especially molecular biology, and engineering. The distinctive thing about it is that it treats cells as programmable devices. It's a kind of tinker toy approach that builds circuits, but not out of wires and switches like we're used to, but rather out of biological components, like proteins and genes. But also, the approach holds promise for illuminating how life works at the deepest level. It's one thing to strip cells apart to see how they work. But it's another thing to tinker with cells to try to get them to perform new tricks, which is something that my guest, Michael Elowitz, does. For example, a while back, he engineered cells to blink on and off like Christmas lights. Michael Elowitz is a professor of biology and biological engineering at Caltech and Howard Hughes Medical Institute. It's great to be here. Strogatz (01:53): So let's talk about the foundational idea of synthetic biology. I mentioned it in the intro, that's -- that living cells, we could think of as programmable devices. The field, synthetic biology, it seems like you guys have this philosophy that you can learn about cells by building functionality into cells yourself.