Invited Speaker and Special Presentation Abstracts

The lab of Atul Butte builds and applies computational tools that convert more than 300 billion points of molecular, clinical, and epidemiological data-measured by researchers and clinicians over the past decade-into new diagnostics, therapeutics, and novel insights into disease. Dr. Butte, a bioinformatician and pediatric endocrinologist, will highlight his team's recent work on clinical evaluations of patients presenting with personal genomes, enabled by the largest curated database of human disease-associated SNP's. With so many genomes now sequenced from individuals from a variety of ethnic backgrounds, and analyzed in a clinical context, Dr. Butte will present how ethnicity alters the background distribution of disease SNP's. Finally, Dr. Butte will also present his team's recent work on environment-wide association studies (EWAS) and how they enable studies of gene-environment interactions.