A Supplementary materials

A.1 Access instructions OpenProteinSet is hosted by the Registry of Open Data on AWS (RODA) and can be accessed at the following link: registry.opendata.aws/openfold/. A.2 Documentation and intended uses We include a datasheet [1] in Section B. Detailed documentation on the precise structure and content of the dataset is provided on the dataset's landing page. A.3 Data format All OpenProteinSet files are in standard plaintext formats (A3M for MSAs, HHSearch format for template hits, and PDB for structure files) that can be read by a wide variety of bioinformatics software. A.5 License OpenProteinSet is made available under the CC BY 4.0 license. A copy of the license is provided with the dataset.