US's new scramble for Africa is biomedical imperialism Late in February, Zimbabwe pulled out of a proposed $367m United States health funding agreement after objecting to provisions requiring broad American access to sensitive health data. The five-year programme was presented as support for HIV/AIDS, tuberculosis, malaria and epidemic preparedness efforts. However, the terms demanded extensive sharing of national health intelligence, including epidemiological surveillance data and pathogen samples, while offering no binding guarantees that Zimbabwe would receive equitable access to medical technologies developed from them. Harare called the proposal an "unequal exchange", warning that Zimbabwe risked supplying the "raw materials for scientific discovery" while the resulting benefits could remain concentrated in the United States and global pharmaceutical firms. Critics increasingly describe this pattern as biomedical extractivism: a toxic combination of exploitative research practices and colonial thinking that reinforces Western dominance.

The development of deep learning approaches for modeling these multifactorial effects of GVs is still in its nascent stages, primarily due to the lack of comprehensive datasets that capture the intricate relationships between GVs and their downstream effects on complex traits.

The field of proteomics aims to study and understand the complex landscape of proteins present within a biological system.

Antibodies are crucial proteins produced by the immune system to eliminate harmful foreign substances and have become pivotal therapeutic agents for treating human diseases.

Advances in high-throughput sequencing technology have led to significant progress in measuring gene expressions at the single-cell level. The amount of publicly available single-cell RNA-seq (scRNA-seq) data is already surpassing 50M records for humans with each record measuring 20,000 genes.

We help address these challenges through three contributions. First, we publish a new dataset, EHRSHOT, which contains de-identified structured data from the electronic health records (EHRs) of 6,739 patients from Stanford Medicine.

RNA plays a pivotal role in translating genetic instructions into functional outcomes, underscoring its importance in biological processes and disease mechanisms.

Addressing these challenges requires scale. To that end we introduce ProteinGym, a large-scale and holistic set of benchmarks specifically designed for protein fitness prediction and design.

Table 3: Comparison of models trained with different representations of protein structure across various tasks, on a random data split . The optimal choice of representation depends on the task. Shown are mean and standard deviation across four runs with different seeds. Table 4: Comparison of models trained with different representations of protein structure across various tasks, on a sequence data split . Table 5: Comparison of models trained with different representations of protein structure across various tasks, on a structure data split .