Analysis of Incursive Breast Cancer in Mammograms Using YOLO, Explainability, and Domain Adaptation

Abstract--Deep learning models for breast cancer detection from mammographic images have significant reliability problems when presented with Out-of-Distribution (OOD) inputs such as other imaging modalities (CT, MRI, X-ray) or equipment variations, leading to unreliable detection and misdiagnosis. Our strategy establishes an in-domain gallery via cosine similarity to rigidly reject non-mammographic inputs prior to processing, ensuring that only domain-associated images supply the detection pipeline. The OOD detection component achieves 99.77% general accuracy with immaculate 100% accuracy on OOD test sets, effectively eliminating irrelevant imaging modalities. ResNet50 was selected as the optimum backbone after 12 CNN architecture searches. The joint framework unites OOD robustness with high detection performance (mAP@0.5: Experimental validation establishes that OOD filtering significantly improves system reliability by preventing false alarms on out-of-distribution inputs while maintaining higher detection accuracy on mammographic data. The present study offers a fundamental foundation for the deployment of reliable AI-based breast cancer detection systems in diverse clinical environments with inherent data heterogeneity. A global health concern, breast cancer is the second-highest cause of cancer related to mortality in women. It has been recorded as the most diagnosed disease in the world in 2020 [1]. According to the World Health Organization, all types of cancer account for 626700 global deaths of women, out of which the breast is the predominant and second leading cause [2]. If diagnosed in its early development stage, the survival rate are likely to be high and the treatment cost will get reduced [3]. Studies has found that 30% breast cancer are diagnosed when the size of the mass is 30mm.