Lung-DETR: Deformable Detection Transformer for Sparse Lung Nodule Anomaly Detection

Accurate lung nodule detection for computed tomography (CT) scan imagery is challenging in real-world settings due to the sparse occurrence of nodules and similarity to other anatomical structures. In a typical positive case, nodules may appear in as few as 3% of CT slices, complicating detection. This paper presents a novel approach to lung tumor detection in CT data by framing the task as anomaly detection, targeting rare nodule occurrences in a predominantly normal dataset. Our novel method, named Lung-DETR combines Deformable Detection Transformer, Focal Loss, and Maximum Intensity Projection into a unified framework for sparse lung nodule detection. A 7.5mm Maximum Intensity Projection (MIP) is utilized to combine adjacent lung slices, decreasing nodule sparsity and enhancing spatial context to allow for better differentiation between nodules, bronchioles, and other complex vascular structures. Lung-DETR is trained with a custom focal loss function to better handle the imbalanced dataset, and outputs bounding boxes around detected nodules. Our model achieves an F1 score of 94.2% (95.2% recall, 93.3% precision) on the LUNA16 dataset, with test dataset nodule sparsity of 4% that is reflective of real-world clinical data.