Robust multi-stage model-based design of optimal experiments for nonlinear estimation

Recently it has also become increasingly important in marketing, medicine and political sciences. Process systems engineering community adopts mathematical models successfully in various endeavors such as product and plant design, control system design, operations optimization, etc. (Pantelides and Renfro, 2013; Fung et al., 2016; Safdarnejad et al., 2016). A mathematical model is usually an abstract representation of a true system via sets of equations (algebraic, ordinary differential or partial differential), inequalities (e.g., a range of model validity), and logical conditions. Model development is usually divided into three major steps a) identification of the model structure, b) design and realization of the experiments, and c) estimation of the unknown parameters. In the latter phase, one often realizes maximum-likelihood estimation via least-squares methodology as he/she assumes--knowingly or not--that the measurement error present in the measured data is statistically distributed as a white Gaussian noise. Once the parameter estimates are known, the experimenter commonly determines the quality of the obtained model. This can be done either by using some validation data--if available--or via assessing the joint-confidence regions of the estimated parameters (Beale, 1960; Bates and Watts, 1988; Rooney and Biegler, 2001; Seber and Wild, 2003).