Efficient Reconstruction of Stochastic Pedigrees
Kim, Younhun, Mossel, Elchanan, Ramnarayan, Govind, Turner, Paxton
We introduce a new algorithm called {\sc Rec-Gen} for reconstructing the genealogy or \textit{pedigree} of an extant population purely from its genetic data. We justify our approach by giving a mathematical proof of the effectiveness of {\sc Rec-Gen} when applied to pedigrees from an idealized generative model that replicates some of the features of real-world pedigrees. Our algorithm is iterative and provides an accurate reconstruction of a large fraction of the pedigree while having relatively low \emph{sample complexity}, measured in terms of the length of the genetic sequences of the population. We propose our approach as a prototype for further investigation of the pedigree reconstruction problem toward the goal of applications to real-world examples. As such, our results have some conceptual bearing on the increasingly important issue of genomic privacy.
May-7-2020
- Country:
- Europe > United Kingdom
- England > Oxfordshire > Oxford (0.04)
- North America > United States
- Massachusetts > Middlesex County
- Cambridge (0.04)
- New York > New York County
- New York City (0.04)
- Massachusetts > Middlesex County
- Europe > United Kingdom
- Genre:
- Research Report > New Finding (0.48)
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