Leveraging Imperfection with MEDLEY A Multi-Model Approach Harnessing Bias in Medical AI

Bias in medical artificial intelligence is conventionally viewed as a defect requiring elimination. However, human reasoning inherently incorporates biases shaped by education, culture, and experience, suggesting their presence may be inevitable and potent ially valuable. We propose MEDLEY (Medical Ensemble Diagnostic system with Leveraged diversit Y), a conceptual framework that orchestrates multiple AI models while preserving their diverse outputs rather than collapsing them into a consensus. Unlike traditional approaches that suppress disagreement, MEDLEY documents model - specific biases as potential strengths and treats hallucinations as provisional hypotheses for clinician verification. A proof - of - concept demonstrator was developed using over 30 large language models, creating a minimum viable product that preserved both consensus and minority views in synthetic cases, making diagnostic uncertainty and latent biases transparent for clinical oversight. While not yet a validated clini cal tool, the demonstration illustrates how structured diversity can enhance medical reasoning under clinician supervision. By reframing AI imperfection as a resource, MEDLEY offers a paradigm shift that opens new regulatory, ethical, and innovation pathwa ys for developing trustworthy medical AI systems.