Computational models provide crucial insights into complex biological processes such as cancer evolution, but their mechanistic nature often makes them nonlinear and parameter-rich, complicating calibration. We systematically evaluate parameter probability distributions in cell migration models using Bayesian calibration across four complementary strategies: parametric and surrogate models, each with and without explicit model discrepancy. This approach enables joint analysis of parameter uncertainty, predictive performance, and interpretability. Applied to a real data experiment of glioblastoma progression in microfluidic devices, surrogate models achieve higher computational efficiency and predictive accuracy, whereas parametric models yield more reliable parameter estimates due to their mechanistic grounding. Incorporating model discrepancy exposes structural limitations, clarifying where model refinement is necessary. Together, these comparisons offer practical guidance for calibrating and improving computational models of complex biological systems.

Bayesian networks (BN) are probabilistic graphical models that enable efficient knowledge representation and inference. These have proven effective across diverse domains, including healthcare, bioinformatics and economics. The structure and parameters of a BN can be obtained by domain experts or directly learned from available data. However, as privacy concerns escalate, it becomes increasingly critical for publicly released models to safeguard sensitive information in training data. Typically, released models do not prioritize privacy by design. In particular, tracing attacks from adversaries can combine the released BN with auxiliary data to determine whether specific individuals belong to the data from which the BN was learned. State-of-the-art protection tecniques involve introducing noise into the learned parameters. While this offers robust protection against tracing attacks, it significantly impacts the model's utility, in terms of both the significance and accuracy of the resulting inferences. Hence, high privacy may be attained at the cost of releasing a possibly ineffective model. This paper introduces credal networks (CN) as a novel solution for balancing the model's privacy and utility. After adapting the notion of tracing attacks, we demonstrate that a CN enables the masking of the learned BN, thereby reducing the probability of successful attacks. As CNs are obfuscated but not noisy versions of BNs, they can achieve meaningful inferences while safeguarding privacy. Moreover, we identify key learning information that must be concealed to prevent attackers from recovering the underlying BN. Finally, we conduct a set of numerical experiments to analyze how privacy gains can be modulated by tuning the CN hyperparameters. Our results confirm that CNs provide a principled, practical, and effective approach towards the development of privacy-aware probabilistic graphical models.

Deep neural networks has been increasingly applied in fault diagnostics, where it uses historical data to capture systems behavior, bypassing the need for high-fidelity physical models. However, despite their competence in prediction tasks, these models often struggle with the evaluation of their confidence. This matter is particularly important in consistency-based diagnosis where decision logic is highly sensitive to false alarms. To address this challenge, this work presents a diagnostic framework that uses ensemble probabilistic machine learning to improve diagnostic characteristics of data driven consistency based diagnosis by quantifying and automating the prediction uncertainty. The proposed method is evaluated across several case studies using both ablation and comparative analyses, showing consistent improvements across a range of diagnostic metrics.

Task vectors capture how a model changes during fine-tuning by recording the difference between pre-trained and task-specific weights. The composition of task vectors, a key operator in task arithmetic, enables models to integrate knowledge from multiple tasks without incurring additional inference costs. In this paper, we propose variational task vector composition, where composition coefficients are taken as latent variables and estimated in a Bayesian inference framework. Unlike previous methods that operate at the task level, our framework focuses on sample-specific composition. Motivated by the observation of structural redundancy in task vectors, we introduce a Spike-and-Slab prior that promotes sparsity and preserves only the most informative components. To further address the high variance and sampling inefficiency in sparse, high-dimensional spaces, we develop a gated sampling mechanism that constructs a controllable posterior by filtering the composition coefficients based on both uncertainty and importance. This yields a more stable and interpretable variational framework by deterministically selecting reliable task components, reducing sampling variance while improving transparency and generalization. Experimental results demonstrate that our method consistently outperforms existing approaches across all datasets by selectively leveraging the most reliable and informative components in task vectors. These findings highlight the practical value of our approach, establishing a new standard for efficient and effective task vector composition.

The paper presents a machine learning approach to design digital interfaces that can dynamically adapt to different users and usage strategies. The algorithm uses Bayesian statistics to model users' browsing behavior, focusing on their habits rather than g roup preferences. It is distinguished by its online incremental learning, allowing reliable predictions even with little data and in the case of a changing environment. This inference method generates a task model, providing a graphical representation of n avigation with the usage statistics of the current user. The algorithm learns new tasks while preserving prior knowledge. The theoretical framework is described, and simulations show the effectiveness of the approach in stationary and non - stationary environments. In conclusion, this research paves the way for adaptive systems that improve the user experience by helping them to better navigate and act on their inter face. The reasons given include that it would be too oriented toward machine learning to speak to a community of HCI researchers and not concrete enough, as well as other reasons that we largely dispute. In light of the comments from the two reviewers, it appears that our non - parametric Bayesian approach was not understood, nor the crucial issue of "sequential, continuous and robust learning" for the design of adaptive user interfaces. 2 1 INTRODUCTION Users are all different. Some have no particular constraints but have usage habits and preferences. Others, such as people with disabilities or seniors, may have, in addition to these habits, constraints when using a digital service. These constraints can be very diverse, of a perceptual nature (visual, auditory, tactile), of a motor nature (pointing, manipulation, speech) or cognitive (reasoning, memory, comprehension, reading...). Consequently, any service, any interface should be able to adjust to these constraints.

In this paper, we present a general specification for Functional Effects Models, which use Machine Learning (ML) methodologies to learn individual-specific preference parameters from socio-demographic characteristics, therefore accounting for inter-individual heterogeneity in panel choice data. We identify three specific advantages of the Functional Effects Model over traditional fixed, and random/mixed effects models: (i) by mapping individual-specific effects as a function of socio-demographic variables, we can account for these effects when forecasting choices of previously unobserved individuals (ii) the (approximate) maximum-likelihood estimation of functional effects avoids the incidental parameters problem of the fixed effects model, even when the number of observed choices per individual is small; and (iii) we do not rely on the strong distributional assumptions of the random effects model, which may not match reality. We learn functional intercept and functional slopes with powerful non-linear machine learning regressors for tabular data, namely gradient boosting decision trees and deep neural networks. We validate our proposed methodology on a synthetic experiment and three real-world panel case studies, demonstrating that the Functional Effects Model: (i) can identify the true values of individual-specific effects when the data generation process is known; (ii) outperforms both state-of-the-art ML choice modelling techniques that omit individual heterogeneity in terms of predictive performance, as well as traditional static panel choice models in terms of learning inter-individual heterogeneity. The results indicate that the FI-RUMBoost model, which combines the individual-specific constants of the Functional Effects Model with the complex, non-linear utilities of RUMBoost, performs marginally best on large-scale revealed preference panel data.

Inference in semi-supervised (SS) settings has gained substantial attention in recent years due to increased relevance in modern big-data problems. In a typical SS setting, there is a much larger-sized unlabeled data, containing only observations of predictors, and a moderately sized labeled data containing observations for both an outcome and the set of predictors. Such data naturally arises when the outcome, unlike the predictors, is costly or difficult to obtain. One of the primary statistical objectives in SS settings is to explore whether parameter estimation can be improved by exploiting the unlabeled data. We propose a novel Bayesian method for estimating the population mean in SS settings. The approach yields estimators that are both efficient and optimal for estimation and inference. The method itself has several interesting artifacts. The central idea behind the method is to model certain summary statistics of the data in a targeted manner, rather than the entire raw data itself, along with a novel Bayesian notion of debiasing. Specifying appropriate summary statistics crucially relies on a debiased representation of the population mean that incorporates unlabeled data through a flexible nuisance function while also learning its estimation bias. Combined with careful usage of sample splitting, this debiasing approach mitigates the effect of bias due to slow rates or misspecification of the nuisance parameter from the posterior of the final parameter of interest, ensuring its robustness and efficiency. Concrete theoretical results, via Bernstein--von Mises theorems, are established, validating all claims, and are further supported through extensive numerical studies. To our knowledge, this is possibly the first work on Bayesian inference in SS settings, and its central ideas also apply more broadly to other Bayesian semi-parametric inference problems.

In this work, we offer a thorough analytical investigation into the role of shared hyperparameters in a hierarchical Bayesian model, examining their impact on information borrowing and posterior inference. Our approach is rooted in a non-asymptotic framework, where observations are drawn from a mixed-effects model, and a Gaussian distribution is assumed for the true effect generator. We consider a nested hierarchical prior distribution model to capture these effects and use the posterior means for Bayesian estimation. To quantify the effect of information borrowing, we propose an integrated risk measure relative to the true data-generating distribution. Our analysis reveals that the Bayes estimator for the model with a deeper hierarchy performs better, provided that the unknown random effects are correlated through a compound symmetric structure. Our work also identifies necessary and sufficient conditions for this model to outperform the one nested within it. We further obtain sufficient conditions when the correlation is perturbed. Our study suggests that the model with a deeper hierarchy tends to outperform the nested model unless the true data-generating distribution favors sufficiently independent groups. These findings have significant implications for Bayesian modeling, and we believe they will be of interest to researchers across a wide range of fields.

Multimodal Large Language Models (MLLMs) have shown promise in visual-textual reasoning, with Multimodal Chain-of-Thought (MCoT) prompting significantly enhancing interpretability. However, existing MCoT methods rely on rationale-rich datasets and largely focus on inter-object reasoning, overlooking the intra-object understanding crucial for image classification. To address this gap, we propose WISE, a Weak-supervision-guided Step-by-step Explanation method that augments any image classification dataset with MCoTs by reformulating the concept-based representations from Concept Bottleneck Models (CBMs) into concise, interpretable reasoning chains under weak supervision. Experiments across ten datasets show that our generated MCoTs not only improve interpretability by 37% but also lead to gains in classification accuracy when used to fine-tune MLLMs. Our work bridges concept-based interpretability and generative MCoT reasoning, providing a generalizable framework for enhancing MLLMs in fine-grained visual understanding.

In this paper, we present the first systematic comparison of Data Assimilation (DA) and Likelihood-Based Inference (LBI) in the context of Agent-Based Models (ABMs). These models generate observable time series driven by evolving, partially-latent microstates. Latent states need to be estimated to align simulations with real-world data -- a task traditionally addressed by DA, especially in continuous and equation-based models such as those used in weather forecasting. However, the nature of ABMs poses challenges for standard DA methods. Solving such issues requires adaptation of previous DA techniques, or ad-hoc alternatives such as LBI. DA approximates the likelihood in a model-agnostic way, making it broadly applicable but potentially less precise. In contrast, LBI provides more accurate state estimation by directly leveraging the model's likelihood, but at the cost of requiring a hand-crafted, model-specific likelihood function, which may be complex or infeasible to derive. We compare the two methods on the Bounded-Confidence Model, a well-known opinion dynamics ABM, where agents are affected only by others holding sufficiently similar opinions. We find that LBI better recovers latent agent-level opinions, even under model mis-specification, leading to improved individual-level forecasts. At the aggregate level, however, both methods perform comparably, and DA remains competitive across levels of aggregation under certain parameter settings. Our findings suggest that DA is well-suited for aggregate predictions, while LBI is preferable for agent-level inference.