This white paper discusses and explores the various points of intersection between quantum computing and artificial intelligence (AI). It describes how quantum computing could support the development of innovative AI solutions. It also examines use cases of classical AI that can empower research and development in quantum technologies, with a focus on quantum computing and quantum sensing. The purpose of this white paper is to provide a long-term research agenda aimed at addressing foundational questions about how AI and quantum computing interact and benefit one another. It concludes with a set of recommendations and challenges, including how to orchestrate the proposed theoretical work, align quantum AI developments with quantum hardware roadmaps, estimate both classical and quantum resources - especially with the goal of mitigating and optimizing energy consumption - advance this emerging hybrid software engineering discipline, and enhance European industrial competitiveness while considering societal implications.

The co creativity community is making significant progress in developing more sophisticated and tailored systems to support and enhance human creativity. Design considerations from prior work can serve as a valuable and efficient foundation for future systems. To support this effort, we conducted a systematic literature review of 62 papers on co-creative systems. These papers cover a diverse range of applications, including visual arts, design, and writing, where the AI acts not just as a tool but as an active collaborator in the creative process. From this review, we identified several key dimensions relevant to system design: phase of the creative process, creative task, proactive behavior of the system, user control, system embodiment, and AI model type. Our findings suggest that systems offering high user control lead to greater satisfaction, trust, and a stronger sense of ownership over creative outcomes. Furthermore, proactive systems, when adaptive and context sensitive, can enhance collaboration. We also extracted 24 design considerations, highlighting the value of encouraging users to externalize their thoughts and of increasing the system's social presence and transparency to foster trust. Despite recent advancements, important gaps remain, such as limited support for early creative phases like problem clarification, and challenges related to user adaptation to AI systems.

Despite AI's impressive achievements, including recent advances in generative and large language models, there remains a significant gap in the ability of AI systems to handle uncertainty and generalize beyond their training data. AI models consistently fail to make robust enough predictions when facing unfamiliar or adversarial data. Traditional machine learning approaches struggle to address this issue, due to an overemphasis on data fitting, while current uncertainty quantification approaches suffer from serious limitations. This position paper posits a paradigm shift towards epistemic artificial intelligence, emphasizing the need for models to learn from what they know while at the same time acknowledging their ignorance, using the mathematics of second-order uncertainty measures. This approach, which leverages the expressive power of such measures to efficiently manage uncertainty, offers an effective way to improve the resilience and robustness of AI systems, allowing them to better handle unpredictable real-world environments.

Pathology is experiencing rapid digital transformation driven by whole-slide imaging and artificial intelligence (AI). While deep learning-based computational pathology has achieved notable success, traditional models primarily focus on image analysis without integrating natural language instruction or rich, text-based context. Current multimodal large language models (MLLMs) in computational pathology face limitations, including insufficient training data, inadequate support and evaluation for multi-image understanding, and a lack of autonomous, diagnostic reasoning capabilities. To address these limitations, we introduce PathChat+, a new MLLM specifically designed for human pathology, trained on over 1 million diverse, pathology-specific instruction samples and nearly 5.5 million question answer turns. Extensive evaluations across diverse pathology benchmarks demonstrated that PathChat+ substantially outperforms the prior PathChat copilot, as well as both state-of-the-art (SOTA) general-purpose and other pathology-specific models. Furthermore, we present SlideSeek, a reasoning-enabled multi-agent AI system leveraging PathChat+ to autonomously evaluate gigapixel whole-slide images (WSIs) through iterative, hierarchical diagnostic reasoning, reaching high accuracy on DDxBench, a challenging open-ended differential diagnosis benchmark, while also capable of generating visually grounded, humanly-interpretable summary reports.

Imitation learning is a central problem in reinforcement learning where the goal is to learn a policy that mimics the expert's behavior. In practice, it is often challenging to learn the expert policy from a limited number of demonstrations accurately due to the complexity of the state space. Moreover, it is essential to explore the environment and collect data to achieve beyond-expert performance. To overcome these challenges, we propose a novel imitation learning algorithm called Imitation Learning with Double Exploration (ILDE), which implements exploration in two aspects: (1) optimistic policy optimization via an exploration bonus that rewards state-action pairs with high uncertainty to potentially improve the convergence to the expert policy, and (2) curiosity-driven exploration of the states that deviate from the demonstration trajectories to potentially yield beyond-expert performance. Empirically, we demonstrate that ILDE outperforms the state-of-the-art imitation learning algorithms in terms of sample efficiency and achieves beyond-expert performance on Atari and MuJoCo tasks with fewer demonstrations than in previous work. We also provide a theoretical justification of ILDE as an uncertainty-regularized policy optimization method with optimistic exploration, leading to a regret growing sublinearly in the number of episodes.

The core challenge in learning has shifted from knowledge acquisition to effective Self-Regulated Learning (SRL): planning, monitoring, and reflecting on one's learning. Existing digital tools, however, inadequately support metacognitive reflection. Spaced Repetition Systems (SRS) use de-contextualized review, overlooking the role of context, while Personal Knowledge Management (PKM) tools require high manual maintenance. To address these challenges, this paper introduces "Insight Recall," a novel paradigm that conceptualizes the context-triggered retrieval of personal past insights as a metacognitive scaffold to promote SRL. We formalize this paradigm using the Just-in-Time Adaptive Intervention (JITAI) framework and implement a prototype system, Irec, to demonstrate its feasibility. At its core, Irec uses a dynamic knowledge graph of the user's learning history. When a user faces a new problem, a hybrid retrieval engine recalls relevant personal "insights." Subsequently, a large language model (LLM) performs a deep similarity assessment to filter and present the most relevant scaffold in a just-in-time manner. To reduce cognitive load, Irec features a human-in-the-loop pipeline for LLM-based knowledge graph construction. We also propose an optional "Guided Inquiry" module, where users can engage in a Socratic dialogue with an expert LLM, using the current problem and recalled insights as context. The contribution of this paper is a solid theoretical framework and a usable system platform for designing next-generation intelligent learning systems that enhance metacognition and self-regulation.

Medical document analysis plays a crucial role in extracting essential clinical insights from unstructured healthcare records, supporting critical tasks such as differential diagnosis. Determining the most probable condition among overlapping symptoms requires precise evaluation and deep medical expertise. While recent advancements in large language models (LLMs) have significantly enhanced performance in medical document analysis, privacy concerns related to sensitive patient data limit the use of online LLMs services in clinical settings. To address these challenges, we propose a trustworthy medical document analysis platform that fine-tunes a LLaMA-v3 using low-rank adaptation, specifically optimized for differential diagnosis tasks. Our approach utilizes DDXPlus, the largest benchmark dataset for differential diagnosis, and demonstrates superior performance in pathology prediction and variable-length differential diagnosis compared to existing methods. The developed web-based platform allows users to submit their own unstructured medical documents and receive accurate, explainable diagnostic results. By incorporating advanced explainability techniques, the system ensures transparent and reliable predictions, fostering user trust and confidence. Extensive evaluations confirm that the proposed method surpasses current state-of-the-art models in predictive accuracy while offering practical utility in clinical settings. This work addresses the urgent need for reliable, explainable, and privacy-preserving artificial intelligence solutions, representing a significant advancement in intelligent medical document analysis for real-world healthcare applications.

This paper outlines a comprehensive theoretical and architectural framework for constructing epistemically grounded artificial intelligence systems capable of propositional commitment, metacognitive reasoning, contradiction detection, and normative truth maintenance. Moving beyond the constraints of stochastic language generation, we propose a model in which artificial agents engage in structured, rule-governed reasoning that adheres to explicit epistemic norms. The approach integrates insights from epistemology, formal logic, inferential semantics, knowledge graph structuring, probabilistic justification, and immutable blockchain evidence to create systems that do not merely simulate knowledge, but operate under explicit, verifiable constraints on belief, justification, and truth. We begin with an analysis of epistemic norms in artificial reasoning, contrasting evi-dentialist, Bayesian, and logical foundations, and establishing a requirement for internal consistency and constraint against falsehood. Central to the proposed system is a prohibition against internal deception: no model component may assert what it internally contradicts.

Multi-condition fault diagnosis is prevalent in industrial systems and presents substantial challenges for conventional diagnostic approaches. The discrepancy in data distributions across different operating conditions degrades model performance when a model trained under one condition is applied to others. With the recent advancements in deep learning, transfer learning has been introduced to the fault diagnosis field as a paradigm for addressing multi-condition fault diagnosis. Among these methods, domain generalization approaches can handle complex scenarios by extracting condition-invariant fault features. Although many studies have considered fault diagnosis in specific multi-condition scenarios, the extent to which operating conditions affect fault information has been scarcely studied, which is crucial. However, the extent to which operating conditions affect fault information has been scarcely studied, which is crucial. When operating conditions have a significant impact on fault features, directly applying domain generalization methods may lead the model to learn condition-specific information, thereby reducing its overall generalization ability. This paper investigates the performance of existing end-to-end domain generalization methods under varying conditions, specifically in variable-speed and variable-load scenarios, using multiple experiments on a real-world gearbox. Additionally, a two-stage diagnostic framework is proposed, aiming to improve fault diagnosis performance under scenarios with significant operating condition impacts. By incorporating a domain-generalized encoder with a retraining strategy, the framework is able to extract condition-invariant fault features while simultaneously alleviating potential overfitting to the source domain. Several experiments on a real-world gearbox dataset are conducted to validate the effectiveness of the proposed approach.

Accurate fault detection in lithium-ion batteries is essential for the safe and reliable operation of electric vehicles and energy storage systems. However, existing methods often struggle to capture complex temporal dependencies and cannot fully leverage abundant unlabeled data. Although large language models (LLMs) exhibit strong representation capabilities, their architectures are not directly suited to the numerical time-series data common in industrial settings. To address these challenges, we propose a novel framework that adapts BERT-style pretraining for battery fault detection by extending the standard BERT architecture with a customized time-series-to-token representation module and a point-level Masked Signal Modeling (point-MSM) pretraining task tailored to battery applications. This approach enables self-supervised learning on sequential current, voltage, and other charge-discharge cycle data, yielding distributionally robust, context-aware temporal embeddings. We then concatenate these embeddings with battery metadata and feed them into a downstream classifier for accurate fault classification. Experimental results on a large-scale real-world dataset show that models initialized with our pretrained parameters significantly improve both representation quality and classification accuracy, achieving an AUROC of 0.945 and substantially outperforming existing approaches. These findings validate the effectiveness of BERT-style pretraining for time-series fault detection.