Conventional biomedical research is increasingly labor-intensive due to the exponential growth of scientific literature and datasets. Artificial intelligence (AI), particularly Large Language Models (LLMs), has the potential to revolutionize this process by automating various steps. Still, significant challenges remain, including the need for multidisciplinary expertise, logicality of experimental design, and performance measurements. This paper introduces BioResearcher, the first end-to-end automated system designed to streamline the entire biomedical research process involving dry lab experiments. BioResearcher employs a modular multi-agent architecture, integrating specialized agents for search, literature processing, experimental design, and programming. By decomposing complex tasks into logically related sub-tasks and utilizing a hierarchical learning approach, BioResearcher effectively addresses the challenges of multidisciplinary requirements and logical complexity. Furthermore, BioResearcher incorporates an LLM-based reviewer for in-process quality control and introduces novel evaluation metrics to assess the quality and automation of experimental protocols. BioResearcher successfully achieves an average execution success rate of 63.07% across eight previously unmet research objectives. The generated protocols averagely outperform typical agent systems by 22.0% on five quality metrics. The system demonstrates significant potential to reduce researchers' workloads and accelerate biomedical discoveries, paving the way for future innovations in automated research systems.

Agentic AI systems use specialized agents to handle tasks within complex workflows, enabling automation and efficiency. However, optimizing these systems often requires labor-intensive, manual adjustments to refine roles, tasks, and interactions. This paper introduces a framework for autonomously optimizing Agentic AI solutions across industries, such as NLP-driven enterprise applications. The system employs agents for Refinement, Execution, Evaluation, Modification, and Documentation, leveraging iterative feedback loops powered by an LLM (Llama 3.2-3B). The framework achieves optimal performance without human input by autonomously generating and testing hypotheses to improve system configurations. This approach enhances scalability and adaptability, offering a robust solution for real-world applications in dynamic environments. Case studies across diverse domains illustrate the transformative impact of this framework, showcasing significant improvements in output quality, relevance, and actionability. All data for these case studies, including original and evolved agent codes, along with their outputs, are here: https://anonymous.4open.science/r/evolver-1D11/

In recent years, as more enterprises have moved their infrastructure to the cloud, significant challenges have emerged in achieving holistic cloud spend visibility and cost optimization. FinOps practices provide a way for enterprises to achieve these business goals by optimizing cloud costs and bringing accountability to cloud spend. This paper presents ABACUS - Automated Budget Analysis and Cloud Usage Surveillance, a FinOps solution for optimizing cloud costs by setting budgets, enforcing those budgets through blocking new deployments, and alerting appropriate teams if spending breaches a budget threshold. ABACUS also leverages best practices like Infrastructure-as-Code to alert engineering teams of the expected cost of deployment before resources are deployed in the cloud. Finally, future research directions are proposed to advance the state of the art in this important field.

As next generation cellular networks become denser, associating users with the optimal base stations at each time while ensuring no base station is overloaded becomes critical for achieving stable and high network performance. We propose multi-agent online Q-learning (QL) algorithms for performing real-time load balancing user association and handover in dense cellular networks. The load balancing constraints at all base stations couple the actions of user agents, and we propose two multi-agent action selection policies, one centralized and one distributed, to satisfy load balancing at every learning step. In the centralized policy, the actions of UEs are determined by a central load balancer (CLB) running an algorithm based on swapping the worst connection to maximize the total learning reward. In the distributed policy, each UE takes an action based on its local information by participating in a distributed matching game with the BSs to maximize the local reward. We then integrate these action selection policies into an online QL algorithm that adapts in real-time to network dynamics including channel variations and user mobility, using a reward function that considers a handover cost to reduce handover frequency. The proposed multi-agent QL algorithm features low-complexity and fast convergence, outperforming 3GPP max-SINR association. Both policies adapt well to network dynamics at various UE speed profiles from walking, running, to biking and suburban driving, illustrating their robustness and real-time adaptability.

We introduce a multi-modal autonomous delivery optimization framework as a coalition game for a fleet of UAVs and ADRs operating in two overlaying networks to address last-mile delivery in urban environments, including high-density areas, road-based routing, and real-world operational challenges. The problem is defined as multiple depot pickup and delivery with time windows constrained over operational restrictions, such as vehicle battery limitation, precedence time window, and building obstruction. Subsequently, the coalition game theory is applied to investigate cooperation structures among the modes to capture how strategic collaboration among vehicles can improve overall routing efficiency. To do so, a generalized reinforcement learning model is designed to evaluate the cost-sharing and allocation to different coalitions for which sub-additive property and non-empty core exist. Our methodology leverages an end-to-end deep multi-agent policy gradient method augmented by a novel spatio-temporal adjacency neighbourhood graph attention network and transformer architecture using a heterogeneous edge-enhanced attention model. Conducting several numerical experiments on last-mile delivery applications, the result from the case study in the city of Mississauga shows that despite the incorporation of an extensive network in the graph for two modes and a complex training structure, the model addresses realistic operational constraints and achieves high-quality solutions compared with the existing transformer-based and heuristics methods and can perform well on non-homogeneous data distribution, generalizes well on the different scale and configuration, and demonstrate a robust performance under stochastic scenarios subject to wind speed and direction.

Readers and scholars often desire a concise summary (Too Long; Didn't Read - TL;DR) of texts to effectively prioritize information. However, creating document summaries is mentally taxing and time-consuming, especially considering the overwhelming volume of documents produced annually, as depicted in Figure 1 by [2], Figure 2, [3] reported over 100,000 scientific articles on the Corona virus pandemic in 2020, though these articles contain brief abstracts of the article, the sheer volume poses challenges for researchers and medical professionals in quickly extracting relevant knowledge on a specific topic. An automatically generated multi-document summarization could be valuable, providing readers with essential information and reducing the need to access original files unless refinement is necessary. Text summarization has garnered significant research attention, proving useful in search engines, news clustering, timeline generation, and various other applications. The objective of text summarization is to create a brief, coherent, factually consistent, and readable document that retains the essential information from the source document, whether it is a single or multi-document. In Single Document Summarization (SDS) only one input document is used, eliminating the need for additional processing to assess relationships between inputs. This method is suitable for summarizing standalone documents such as emails, legal contracts, financial reports and so on. The primary goal of Multi Document Summarization (MDS) is to gather information from several texts addressing the same topic, often composed at different times or representing diverse perspectives. The overarching objective is to produce information reports that are both succinct and comprehensive, consolidating varied opinions from documents that explore a topic through multiple viewpoints.

Scaling laws for inference compute in multi-agent systems remain under-explored compared to single-agent scenarios. This work aims to bridge this gap by investigating the problem of data synthesis through multi-agent sampling, where synthetic responses are generated by sampling from multiple distinct language models. Effective model coordination is crucial for successful multi-agent collaboration. Unlike previous approaches that rely on fixed workflows, we treat model coordination as a multi-step decision-making process, optimizing generation structures dynamically for each input question. We introduce Tree Search-based Orchestrated Agents~(TOA), where the workflow evolves iteratively during the sequential sampling process. To achieve this, we leverage Monte Carlo Tree Search (MCTS), integrating a reward model to provide real-time feedback and accelerate exploration. Our experiments on alignment, machine translation, and mathematical reasoning demonstrate that multi-agent sampling significantly outperforms single-agent sampling as inference compute scales. TOA is the most compute-efficient approach, achieving SOTA performance on WMT and a 71.8\% LC win rate on AlpacaEval. Moreover, fine-tuning with our synthesized alignment data surpasses strong preference learning methods on challenging benchmarks such as Arena-Hard and AlpacaEval.

Real-world data is represented in both structured (e.g., graph connections) and unstructured (e.g., textual, visual information) formats, encompassing complex relationships that include explicit links (such as social connections and user behaviors) and implicit interdependencies among semantic entities, often illustrated through knowledge graphs. In this work, we propose GraphAgent, an automated agent pipeline that addresses both explicit graph dependencies and implicit graph-enhanced semantic inter-dependencies, aligning with practical data scenarios for predictive tasks (e.g., node classification) and generative tasks (e.g., text generation). GraphAgent comprises three key components: (i) a Graph Generator Agent that builds knowledge graphs to reflect complex semantic dependencies; (ii) a Task Planning Agent that interprets diverse user queries and formulates corresponding tasks through agentic self-planning; and (iii) a Task Execution Agent that efficiently executes planned tasks while automating tool matching and invocation in response to user queries. These agents collaborate seamlessly, integrating language models with graph language models to uncover intricate relational information and data semantic dependencies. Through extensive experiments on various graph-related predictive and text generative tasks on diverse datasets, we demonstrate the effectiveness of our GraphAgent across various settings. We have made our proposed GraphAgent open-source at: https://github.com/HKUDS/GraphAgent.

Explaining multi-agent systems (MAS) is urgent as these systems become increasingly prevalent in various applications. Previous work has proveided explanations for the actions or states of agents, yet falls short in understanding the black-boxed agent's importance within a MAS and the overall team strategy. To bridge this gap, we propose EMAI, a novel agent-level explanation approach that evaluates the individual agent's importance. Inspired by counterfactual reasoning, a larger change in reward caused by the randomized action of agent indicates its higher importance. We model it as a MARL problem to capture interactions across agents. Utilizing counterfactual reasoning, EMAI learns the masking agents to identify important agents. Specifically, we define the optimization function to minimize the reward difference before and after action randomization and introduce sparsity constraints to encourage the exploration of more action randomization of agents during training. The experimental results in seven multi-agent tasks demonstratee that EMAI achieves higher fidelity in explanations than baselines and provides more effective guidance in practical applications concerning understanding policies, launching attacks, and patching policies.

Multi-Agent Path Finding (MAPF) seeks collision-free paths for multiple agents from their respective starting locations to their respective goal locations while minimizing path costs. Although many MAPF algorithms were developed and can handle up to thousands of agents, they usually rely on the assumption that each action of the agent takes a time unit, and the actions of all agents are synchronized in a sense that the actions of agents start at the same discrete time step, which may limit their use in practice. Only a few algorithms were developed to address asynchronous actions, and they all lie on one end of the spectrum, focusing on finding optimal solutions with limited scalability. This paper develops new planners that lie on the other end of the spectrum, trading off solution quality for scalability, by finding an unbounded sub-optimal solution for many agents. Our method leverages both search methods (LSS) in handling asynchronous actions and rule-based planning methods (PIBT) for MAPF. We analyze the properties of our method and test it against several baselines with up to 1000 agents in various maps. Given a runtime limit, our method can handle an order of magnitude more agents than the baselines with about 25% longer makespan.