Motion prediction, recently popularized under the term world models, refers to anticipating the future states of agents or the future evolution of a scene, which is rooted in human cognition to bridge perception and decision-making, enabling us to anticipate, adapt, and act within an ever-changing world. It lies at the core of intelligent autonomous systems, such as robotics and self-driving cars, to safely operate in dynamic and human-robot-mixed environments, and also informs broader time-series challenges. With advances in methods, representations, and datasets, the field has seen rapid progress, reflected in rapidly updated benchmark performance. However, when state-of-the-art methods are deployed in the real world, they are often found to struggle to generalize to open-world settings and fall short of deployment standards. This reveals a gap between reality and benchmarks, which are often idealized or ill-posed, and fail to capture real-world complexity. To address the pressing need for problem settings that better reflect real-world challenges and guide future research, this paper focuses on revisiting the generalization and applicability of motion prediction models, with an emphasis on robotics, autonomous driving, and human motion applications. We first provide a comprehensive taxonomy of motion prediction methods, covering representations, modelling methods, application domains, and evaluation protocols. We then revisit two fundamental problems: 1) how to push motion prediction models to be deployable to realistic deployment standards, where motion prediction does not act in a vacuum, but functions as one module of closed-loop autonomy stacks - it takes input from the localization and perception, and informs downstream planning and control.

In real-world multi-agent systems (MASs), observation delays are ubiquitous, preventing agents from making decisions based on the environment's true state. An individual agent's local observation typically comprises multiple components from other agents or dynamic entities within the environment. These discrete observation components with varying delay characteristics pose significant challenges for multi-agent reinforcement learning (MARL). In this paper, we first formulate the decentralized stochastic individual delay partially observable Markov decision process (DSID-POMDP) by extending the standard Dec-POMDP. We then propose the Rainbow Delay Compensation (RDC), a MARL training framework for addressing stochastic individual delays, along with recommended implementations for its constituent modules. We implement the DSID-POMDP's observation generation pattern using standard MARL benchmarks, including MPE and SMAC. Experiments demonstrate that baseline MARL methods suffer severe performance degradation under fixed and unfixed delays. The RDC-enhanced approach mitigates this issue, remarkably achieving ideal delay-free performance in certain delay scenarios while maintaining generalizability. Our work provides a novel perspective on multi-agent delayed observation problems and offers an effective solution framework. The source code is available at https://github.com/linkjoker1006/RDC-pymarl.

This paper introduces a structured approach to improving decision making in Decentralized Autonomous Organizations (DAO) through the integration of the Question-Option-Criteria (QOC) model and AI agents. We outline a stepwise governance framework that evolves from human led evaluations to fully autonomous, AI-driven processes. By decomposing decisions into weighted, criterion based evaluations, the QOC model enhances transparency, fairness, and explainability in DAO voting. We demonstrate how large language models (LLMs) and stakeholder aligned AI agents can support or automate evaluations, while statistical safeguards help detect manipulation. The proposed framework lays the foundation for scalable and trustworthy governance in the Web3 ecosystem.

Hit identification is a central challenge in early drug discovery, traditionally requiring substantial experimental resources. Recent advances in artificial intelligence, particularly large language models (LLMs), have enabled virtual screening methods that reduce costs and improve efficiency. However, the growing complexity of these tools has limited their accessibility to wet-lab researchers. Multi-agent systems offer a promising solution by combining the interpretability of LLMs with the precision of specialized models and tools. In this work, we present MADD, a multi-agent system that builds and executes customized hit identification pipelines from natural language queries. MADD employs four coordinated agents to handle key subtasks in de novo compound generation and screening. We evaluate MADD across seven drug discovery cases and demonstrate its superior performance compared to existing LLM-based solutions. Using MADD, we pioneer the application of AI-first drug design to five biological targets and release the identified hit molecules. Finally, we introduce a new benchmark of query-molecule pairs and docking scores for over three million compounds to contribute to the agentic future of drug design.

Readability is a key concept in the current era of abundant written information. To help making texts more readable and make information more accessible to everyone, a line of researched aims at making texts accessible for their target audience: automatic text simplification (ATS). Lately, there have been studies on the correlations between automatic evaluation metrics in ATS and human judgment. However, the correlations between those two aspects and commonly available readability measures (such as readability formulas or linguistic features) have not been the focus of as much attention. In this work, we investigate the place of readability measures in ATS by complementing the existing studies on evaluation metrics and human judgment, on English. We first discuss the relationship between ATS and research in readability, then we report a study on correlations between readability measures and human judgment, and between readability measures and ATS evaluation metrics. We identify that in general, readability measures do not correlate well with automatic metrics and human judgment. We argue that as the three different angles from which simplification can be assessed tend to exhibit rather low correlations with one another, there is a need for a clear definition of the construct in ATS.

Adversarial optimization algorithms that explicitly search for flaws in agents' policies have been successfully applied to finding robust and diverse policies in multi-agent settings. However, the success of adversarial optimization has been largely limited to zero-sum settings because its naive application in cooperative settings leads to a critical failure mode: agents are irrationally incentivized to self-sabotage, blocking the completion of tasks and halting further learning. To address this, we introduce Rationality-preserving Policy Optimization (RPO), a formalism for adversarial optimization that avoids self-sabotage by ensuring agents remain rational--that is, their policies are optimal with respect to some possible partner policy. To solve RPO, we develop Rational Policy Gradient (RPG), which trains agents to maximize their own reward in a modified version of the original game in which we use opponent shaping techniques to optimize the adversarial objective. RPG enables us to extend a variety of existing adversarial optimization algorithms that, no longer subject to the limitations of self-sabotage, can find adversarial examples, improve robustness and adaptability, and learn diverse policies. We empirically validate that our approach achieves strong performance in several popular cooperative and general-sum environments. Our project page can be found at https://rational-policy-gradient.github.io.

This paper investigates how individual entrepreneurs can turn creative ideas into successful solo businesses in an era increasingly shaped by Artificial Intelligence (AI) agents. It highlights the key steps that connect personal vision, structured experimentation, and lasting value creation, and shows how AI agents can act as digital co-founders throughout this journey. Building on research in entrepreneurship, creativity, and innovation, we present a framework with three key stages: (1) Imagination shaping, where vague goals become clear value propositions, supported by AI agents that help with market scanning, idea refinement, and rapid concept generation; (2) Reality testing, where these ideas are tested through low-cost experiments, structured feedback loops, and efficient execution, with AI agents automating tasks such as prototyping, content creation, customer interaction, and data analysis; and (3) Reality scaling, where successful ideas are transformed into repeatable processes, scalable market strategies, and long-term business models, increasingly operated and optimized by autonomous or semi-autonomous AI workflows. We focus on the specific context of solopreneurship, characterized by limited human resources, complete accountability for decision-making, and a strong association between the founder's identity and the business. The framework clearly identifies key enabling factors such as mental adaptability, effective planning, and successful human-AI collaboration within digital ecosystems. It also thoughtfully addresses ongoing challenges, like uncertainty and cognitive overload, which are heightened by our constant connectivity.

This work will elaborate the fundamental principles of physical artificial intelligence (Physical AI) from a scientific and systemic perspective. The aim is to create a theoretical foundation that describes the physical embodiment, sensory perception, ability to act, learning processes, and context sensitivity of intelligent systems within a coherent framework. While classical AI approaches rely on symbolic processing and data driven models, Physical AI understands intelligence as an emergent phenomenon of real interaction between body, environment, and experience. The six fundamentals presented here are embodiment, sensory perception, motor action, learning, autonomy, and context sensitivity, and form the conceptual basis for designing and evaluating physically intelligent systems. Theoretically, it is shown that these six principles do not represent loose functional modules but rather act as a closed control loop in which energy, information, control, and context are in constant interaction. This circular interaction enables a system to generate meaning not from databases, but from physical experience, a paradigm shift that understands intelligence as an physical embodied process. Physical AI understands learning not as parameter adjustment, but as a change in the structural coupling between agents and the environment. To illustrate this, the theoretical model is explained using a practical scenario: An adaptive assistant robot supports patients in a rehabilitation clinic. This example illustrates that physical intelligence does not arise from abstract calculation, but from immediate, embodied experience. It shows how the six fundamentals interact in a real system: embodiment as a prerequisite, perception as input, movement as expression, learning as adaptation, autonomy as regulation, and context as orientation.

Decentralized collision avoidance remains a core challenge for scalable multi-robot systems. One of the promising approaches to tackle this problem is Model Predictive Path Integral (MPPI) -- a framework that is naturally suited to handle any robot motion model and provides strong theoretical guarantees. Still, in practice MPPI-based controller may provide suboptimal trajectories as its performance relies heavily on uninformed random sampling. In this work, we introduce CoRL-MPPI, a novel fusion of Cooperative Reinforcement Learning and MPPI to address this limitation. We train an action policy (approximated as deep neural network) in simulation that learns local cooperative collision avoidance behaviors. This learned policy is then embedded into the MPPI framework to guide its sampling distribution, biasing it towards more intelligent and cooperative actions. Notably, CoRL-MPPI preserves all the theoretical guarantees of regular MPPI. We evaluate our approach in dense, dynamic simulation environments against state-of-the-art baselines, including ORCA, BVC, and a multi-agent MPPI implementation. Our results demonstrate that CoRL-MPPI significantly improves navigation efficiency (measured by success rate and makespan) and safety, enabling agile and robust multi-robot navigation.

Multi-Agent Systems (MAS) have emerged as a powerful paradigm for modeling complex interactions among autonomous entities in distributed environments. In Multi-Agent Reinforcement Learning (MARL), communication enables coordination but can lead to inefficient information exchange, since agents may generate redundant or non-essential messages. While prior work has focused on boosting task performance with information exchange, the existing research lacks a thorough investigation of both the appropriate definition and the optimization of communication protocols (communication topology and message). To fill this gap, we introduce a generalized framework for learning multi-round communication protocols that are both effective and efficient. Within this framework, we propose three novel Communication Efficiency Metrics (CEMs) to guide and evaluate the learning process: the Information Entropy Efficiency Index (IEI) and Specialization Efficiency Index (SEI) for efficiency-augmented optimization, and the Topology Efficiency Index (TEI) for explicit evaluation. We integrate IEI and SEI as the adjusted loss functions to promote informative messaging and role specialization, while using TEI to quantify the trade-off between communication volume and task performance. Through comprehensive experiments, we demonstrate that our learned communication protocol can significantly enhance communication efficiency and achieves better cooperation performance with improved success rates.