Machine learning (ML) exhibits promise in the clinical domain. However, it is constrained by data scarcity and ethical considerations, as the generation of clinical trials presents significant challenges due to stringent privacy regulations, high costs, and the extended duration required for conducting studies with human participants. Despite the advancements of large language models (LLMs) in general generation tasks, their potential in facilitating the generation of synthetic clinical trials is under-explored. To address this gap, we introduce a novel Retrieval-Reasoning few-shot framework that leverages LLMs to generate artificial yet realistic and diverse clinical trials with binary success/failure labels. Experiments conducted on real clinical trials from the \url{ClinicalTrials.gov} database demonstrate that our synthetic data can effectively augment real datasets. Furthermore, by fine-tuning a pre-trained model as a binary classifier on synthetic clinical trial datasets, we demonstrate that this augmentation enhances model training for downstream tasks such as trial outcome prediction. Our findings suggest that LLMs for synthetic clinical trial generation hold promise for accelerating clinical research and upholding ethical standards for patient privacy. The code is publicly available at https://anonymous.4open.science/r/Retrieval_Reasoning_Clinical_Trial_Generation-3EC4.

PRefLexOR (Preference-based Recursive Language Modeling for Exploratory Optimization of Reasoning) combines preference optimization with concepts from Reinforcement Learning to enable models to self-teach through iterative reasoning improvements. We propose a recursive learning approach that engages the model in multi-step reasoning, revisiting, and refining intermediate steps before producing a final output in training and inference phases. Through multiple training stages, the model first learns to align its reasoning with accurate decision paths by optimizing the log odds between preferred and non-preferred responses. During this process, PRefLexOR builds a dynamic knowledge graph by generating questions from random text chunks and retrieval-augmentation to contextualize relevant details from the entire training corpus. In the second stage, preference optimization enhances model performance by using rejection sampling to fine-tune reasoning quality by continually producing in-situ training data while masking the reasoning steps. Recursive optimization within a thinking token framework introduces iterative feedback loops, where the model refines reasoning, achieving deeper coherence, consistency, and adaptability. Implemented in small language models with only 3 billion parameters, we should that even tiny models can iteratively teach themselves to reason with greater depth and reflectivity. Our implementation is straightforward and can be incorporated into any existing pretrained LLM. We focus our examples on applications in biological materials science and demonstrate the method in a variety of case studies that range from in-domain to cross-domain applications. Using reasoning strategies that include thinking and reflection modalities we build a multi-agent recursive self-improving inference approach to successively improve responses via repeated sampling in inference time.

In this work, we focus our attention on developing a benchmark for instruction-following where it is easy to verify both task performance as well as instruction-following capabilities. We adapt existing knowledge benchmarks and augment them with instructions that are a) conditional on correctly answering the knowledge task or b) use the space of candidate options in multiple-choice knowledge-answering tasks. This allows us to study model characteristics, such as their change in performance on the knowledge tasks in the presence of answer-modifying instructions and distractor instructions. In contrast to existing benchmarks for instruction following, we not only measure instruction-following capabilities but also use LLM-free methods to study task performance. We study a series of openly available large language models of varying parameter sizes (1B-405B) and closed source models namely GPT-4o-mini, GPT-4o. We find that even large-scale instruction-tuned LLMs fail to follow simple instructions in zero-shot settings. We release our dataset, the benchmark, code, and results for future work.

Recent research has focused on the medium and long-term impacts of generative AI, posing scientific and societal challenges mainly due to the detection and reliability of machine-generated information, which is projected to form the major content on the Web soon. Prior studies show that LLMs exhibit a lower performance in generation tasks (model collapse) as they undergo a fine-tuning process across multiple generations on their own generated content (self-consuming loop). In this paper, we present a comprehensive simulation framework built upon the chat version of LLama2, focusing particularly on the linguistic aspects of the generated content, which has not been fully examined in existing studies. Our results show that the model produces less lexical rich content across generations, reducing diversity. The lexical richness has been measured using the linguistic measures of entropy and TTR as well as calculating the POSTags frequency. The generated content has also been examined with an $n$-gram analysis, which takes into account the word order, and semantic networks, which consider the relation between different words. These findings suggest that the model collapse occurs not only by decreasing the content diversity but also by distorting the underlying linguistic patterns of the generated text, which both highlight the critical importance of carefully choosing and curating the initial input text, which can alleviate the model collapse problem. Furthermore, we conduct a qualitative analysis of the fine-tuned models of the pipeline to compare their performances on generic NLP tasks to the original model. We find that autophagy transforms the initial model into a more creative, doubtful and confused one, which might provide inaccurate answers and include conspiracy theories in the model responses, spreading false and biased information on the Web.

Developing effective text summarizers remains a challenge due to issues like hallucinations, key information omissions, and verbosity in LLM-generated summaries. This work explores using LLM-generated feedback to improve summary quality by aligning the summaries with human preferences for faithfulness, completeness, and conciseness. We introduce FeedSum, a large-scale dataset containing multi-dimensional LLM feedback on summaries of varying quality across diverse domains. Our experiments show how feedback quality, dimensionality, and granularity influence preference learning, revealing that high-quality, multi-dimensional, fine-grained feedback significantly improves summary generation. We also compare two methods for using this feedback: supervised fine-tuning and direct preference optimization. Finally, we introduce SummLlama3-8b, a model that outperforms the nearly 10x larger Llama3-70b-instruct in generating human-preferred summaries, demonstrating that smaller models can achieve superior performance with appropriate training. The full dataset will be released soon. The SummLlama3-8B model is now available at https://huggingface.co/DISLab/SummLlama3-8B.

We present LEGAL-UQA, the first Urdu legal question-answering dataset derived from Pakistan's constitution. This parallel English-Urdu dataset includes 619 question-answer pairs, each with corresponding legal article contexts, addressing the need for domain-specific NLP resources in low-resource languages. We describe the dataset creation process, including OCR extraction, manual refinement, and GPT-4-assisted translation and generation of QA pairs. Our experiments evaluate the latest generalist language and embedding models on LEGAL-UQA, with Claude-3.5-Sonnet achieving 99.19% human-evaluated accuracy. We fine-tune mt5-large-UQA-1.0, highlighting the challenges of adapting multilingual models to specialized domains. Additionally, we assess retrieval performance, finding OpenAI's text-embedding-3-large outperforms Mistral's mistral-embed. LEGAL-UQA bridges the gap between global NLP advancements and localized applications, particularly in constitutional law, and lays the foundation for improved legal information access in Pakistan.

The Open Ko-LLM Leaderboard has been instrumental in benchmarking Korean Large Language Models (LLMs), yet it has certain limitations. Notably, the disconnect between quantitative improvements on the overly academic leaderboard benchmarks and the qualitative impact of the models should be addressed. Furthermore, the benchmark suite is largely composed of translated versions of their English counterparts, which may not fully capture the intricacies of the Korean language. To address these issues, we propose Open Ko-LLM Leaderboard2, an improved version of the earlier Open Ko-LLM Leaderboard. The original benchmarks are entirely replaced with new tasks that are more closely aligned with real-world capabilities. Additionally, four new native Korean benchmarks are introduced to better reflect the distinct characteristics of the Korean language. Through these refinements, Open Ko-LLM Leaderboard2 seeks to provide a more meaningful evaluation for advancing Korean LLMs.

Attributing answers to source documents is an approach used to enhance the verifiability of a model's output in retrieval augmented generation (RAG). Prior work has mainly focused on improving and evaluating the attribution quality of large language models (LLMs) in RAG, but this may come at the expense of inducing biases in the attribution of answers. We define and examine two aspects in the evaluation of LLMs in RAG pipelines, namely attribution sensitivity and bias with respect to authorship information. We explicitly inform an LLM about the authors of source documents, instruct it to attribute its answers, and analyze (i) how sensitive the LLM's output is to the author of source documents, and (ii) whether the LLM exhibits a bias towards human-written or AI-generated source documents. We design an experimental setup in which we use counterfactual evaluation to study three LLMs in terms of their attribution sensitivity and bias in RAG pipelines. Our results show that adding authorship information to source documents can significantly change the attribution quality of LLMs by 3% to 18%. Moreover, we show that LLMs can have an attribution bias towards explicit human authorship, which can serve as a competing hypothesis for findings of prior work that shows that LLM-generated content may be preferred over human-written contents. Our findings indicate that metadata of source documents can influence LLMs' trust, and how they attribute their answers. Furthermore, our research highlights attribution bias and sensitivity as a novel aspect of brittleness in LLMs.

Large language models (LLMs) have been a disruptive innovation in recent years, and they play a crucial role in our daily lives due to their ability to understand and generate human-like text. Their capabilities include natural language understanding, information retrieval and search, translation, chatbots, virtual assistance, and many more. However, it is well known that LLMs are massive in terms of the number of parameters. Additionally, the self-attention mechanism in the underlying architecture of LLMs, Transformers, has quadratic complexity in terms of both computation and memory with respect to the input sequence length. For these reasons, LLM inference is resource-intensive, and thus, the throughput of LLM inference is limited, especially for the longer sequences. In this report, we design a collaborative inference architecture between a server and its clients to alleviate the throughput limit. In this design, we consider the available resources on both sides, i.e., the computation and communication costs. We develop a dynamic programming-based algorithm to optimally allocate computation between the server and the client device to increase the server throughput, while not violating the service level agreement (SLA). We show in the experiments that we are able to efficiently distribute the workload allowing for roughly 1/3 reduction in the server workload, while achieving 19 percent improvement over a greedy method. As a result, we are able to demonstrate that, in an environment with different types of LLM inference requests, the throughput of the server is improved.

In-context knowledge editing (IKE) enables efficient modification of large language model (LLM) outputs without parameter changes and at zero-cost. However, it can be misused to manipulate responses opaquely, e.g., insert misinformation or offensive content. Such malicious interventions could be incorporated into high-level wrapped APIs where the final input prompt is not shown to end-users. To address this issue, we investigate the detection and reversal of IKE-edits. First, we demonstrate that IKE-edits can be detected with high accuracy (F1 > 80\%) using only the top-10 output probabilities of the next token, even in a black-box setting, e.g. proprietary LLMs with limited output information. Further, we introduce the novel task of reversing IKE-edits using specially tuned reversal tokens. We explore using both continuous and discrete reversal tokens, achieving over 80\% accuracy in recovering original, unedited outputs across multiple LLMs. Our continuous reversal tokens prove particularly effective, with minimal impact on unedited prompts. Through analysis of output distributions, attention patterns, and token rankings, we provide insights into IKE's effects on LLMs and how reversal tokens mitigate them. This work represents a significant step towards enhancing LLM resilience against potential misuse of in-context editing, improving their transparency and trustworthiness.