Molecular fingerprinting methods use hash functions to create fixed-length vector representations of molecules. However, hash collisions cause distinct substructures to be represented with the same feature, leading to overestimates in molecular similarity calculations. We investigate whether using exact fingerprints improves accuracy compared to standard compressed fingerprints in molecular property prediction and Bayesian optimization where the underlying predictive model is a Gaussian process. We find that using exact fingerprints yields a small yet consistent improvement in predictive accuracy on five molecular property prediction benchmarks from the DOCKSTRING dataset. However, these gains did not translate to significant improvements in Bayesian optimization performance.

Chest radiography remains one of the most widely used imaging modalities for thoracic diagnosis, yet increasing imaging volumes and radiologist workload continue to challenge timely interpretation. In this work, we investigate the use of MedImageInsight, a medical imaging foundational model, for automated binary classification of chest X-rays into Normal and Abnormal categories. Two approaches were evaluated: (1) fine-tuning MedImageInsight for end-to-end classification, and (2) employing the model as a feature extractor for a transfer learning pipeline using traditional machine learning classifiers. Experiments were conducted using a combination of the ChestX-ray14 dataset and real-world clinical data sourced from partner hospitals. The fine-tuned classifier achieved the highest performance, with an ROC-AUC of 0.888 and superior calibration compared to the transfer learning models, demonstrating performance comparable to established architectures such as CheXNet. These results highlight the effectiveness of foundational medical imaging models in reducing task-specific training requirements while maintaining diagnostic reliability. The system is designed for integration into web-based and hospital PACS workflows to support triage and reduce radiologist burden. Future work will extend the model to multi-label pathology classification to provide preliminary diagnostic interpretation in clinical environments.

Monitoring aquatic species, especially elusive ones like lobsters, presents challenges. This study focuses on Homarus gammarus (European lobster), a key species for fisheries and aquaculture, and leverages non-invasive Passive Acoustic Monitoring (PAM). Understanding lobster habitats, welfare, reproduction, sex, and age is crucial for management and conservation. While bioacoustic emissions have classified various aquatic species using Artificial Intelligence (AI) models, this research specifically uses H. gammarus bioacoustics (buzzing/carapace vibrations) to classify lobsters by age (juvenile/adult) and sex (male/female). The dataset was collected at Johnshaven, Scotland, using hydrophones in concrete tanks. We explored the efficacy of Deep Learning (DL) models (1D-CNN, 1D-DCNN) and six Machine Learning (ML) models (SVM, k-NN, Naive Bayes, Random Forest, XGBoost, MLP). Mel-frequency cepstral coefficients (MFCCs) were used as features. For age classification (adult vs. juvenile), most models achieved over 97% accuracy (Naive Bayes: 91.31%). For sex classification, all models except Naive Bayes surpassed 93.23%. These strong results demonstrate the potential of supervised ML and DL to extract age- and sex-related features from lobster sounds. This research offers a promising non-invasive PAM approach for lobster conservation, detection, and management in aquaculture and fisheries, enabling real-world edge computing applications for underwater species.

In this work, we study English-language vaccine discourse in social media posts, specifically posts on X (formerly Twitter), in seven years before the COVID-19 outbreak (2013 to 2019) and three years after the outbreak was first reported (2020 to 2022). Drawing on theories from social cognition and the stereotype content model in Social Psychology, we analyze how English speakers talk about vaccines on social media to understand the evolving narrative around vaccines in social media posts. To do that, we first introduce a novel dataset comprising 18.7 million curated posts on vaccine discourse from 2013 to 2022. This extensive collection-filtered down from an initial 129 million posts through rigorous preprocessing-captures both pre-COVID and COVID-19 periods, offering valuable insights into the evolution of English-speaking X users' perceptions related to vaccines. Our analysis shows that the COVID-19 pandemic led to complex shifts in X users' sentiment and discourse around vaccines. We observe that negative emotion word usage decreased during the pandemic, with notable rises in usage of surprise, and trust related emotion words. Furthermore, vaccine-related language tended to use more warmth-focused words associated with trustworthiness, along with positive, competence-focused words during the early days of the pandemic, with a marked rise in negative word usage towards the end of the pandemic, possibly reflecting a growing vaccine hesitancy and skepticism.

Membership inference attacks (MIAs) against machine learning (ML) models aim to determine whether a given data point was part of the model training data. These attacks may pose significant privacy risks to individuals whose sensitive data were used for training, which motivates the use of defenses such as differential privacy, often at the cost of high accuracy losses. MIAs exploit the differences in the behavior of a model when making predictions on samples it has seen during training (members) versus those it has not seen (non-members). Several studies have pointed out that model overfitting is the major factor contributing to these differences in behavior and, consequently, to the success of MIAs. However, the literature also shows that even non-overfitted ML models can leak information about a small subset of their training data. In this paper, we investigate the root causes of membership inference vulnerabilities beyond traditional overfitting concerns and suggest targeted defenses. We empirically analyze the characteristics of the training data samples vulnerable to MIAs in models that are not overfitted (and hence able to generalize). Our findings reveal that these samples are often outliers within their classes (e.g., noisy or hard to classify). We then propose potential defensive strategies to protect these vulnerable samples and enhance the privacy-preserving capabilities of ML models.

We present Segment Anything Model (SAM) 3, a unified model that detects, segments, and tracks objects in images and videos based on concept prompts, which we define as either short noun phrases (e.g., "yellow school bus"), image exemplars, or a combination of both. Promptable Concept Segmentation (PCS) takes such prompts and returns segmentation masks and unique identities for all matching object instances. To advance PCS, we build a scalable data engine that produces a high-quality dataset with 4M unique concept labels, including hard negatives, across images and videos. Our model consists of an image-level detector and a memory-based video tracker that share a single backbone. Recognition and localization are decoupled with a presence head, which boosts detection accuracy. SAM 3 doubles the accuracy of existing systems in both image and video PCS, and improves previous SAM capabilities on visual segmentation tasks. We open source SAM 3 along with our new Segment Anything with Concepts (SA-Co) benchmark for promptable concept segmentation.

Evaluating adherence to PRISMA 2020 guideline remains a burden in the peer review process. To address the lack of shareable benchmarks, we constructed a copyright-aware benchmark of 108 Creative Commons-licensed systematic reviews and evaluated ten large language models (LLMs) across five input formats. In a development cohort, supplying structured PRISMA 2020 checklists (Markdown, JSON, XML, or plain text) yielded 78.7-79.7% accuracy versus 45.21% for manuscript-only input (p less than 0.0001), with no differences between structured formats (p>0.9). Across models, accuracy ranged from 70.6-82.8% with distinct sensitivity-specificity trade-offs, replicated in an independent validation cohort. We then selected Qwen3-Max (a high-sensitivity open-weight model) and extended evaluation to the full dataset (n=120), achieving 95.1% sensitivity and 49.3% specificity. Structured checklist provision substantially improves LLM-based PRISMA assessment, though human expert verification remains essential before editorial decisions.

Large Language Models (LLMs) are the engines driving today's AI agents. The better these models understand human languages, the more natural and user-friendly the interaction with AI becomes, from everyday devices like computers and smartwatches to any tool that can act intelligently. Yet, the ability of industrial-scale LLMs to comprehend low-resource languages, such as Tunisian Arabic (Tunizi), is often overlooked. This neglect risks excluding millions of Tunisians from fully interacting with AI in their own language, pushing them toward French or English. Such a shift not only threatens the preservation of the Tunisian dialect but may also create challenges for literacy and influence younger generations to favor foreign languages. In this study, we introduce a novel dataset containing parallel Tunizi, standard Tunisian Arabic, and English translations, along with sentiment labels. We benchmark several popular LLMs on three tasks: transliteration, translation, and sentiment analysis. Our results reveal significant differences between models, highlighting both their strengths and limitations in understanding and processing Tunisian dialects. By quantifying these gaps, this work underscores the importance of including low-resource languages in the next generation of AI systems, ensuring technology remains accessible, inclusive, and culturally grounded.

Depression is a prevalent global mental health disorder, characterised by persistent low mood and anhedonia. However, it remains underdiagnosed because current diagnostic methods depend heavily on subjective clinical assessments. To enable objective detection, we introduce a gold standard dataset of 103 clinically assessed participants collected through a tripartite data approach which uniquely integrated eye tracking data with audio and video to give a comprehensive representation of depressive symptoms. Eye tracking data quantifies the attentional bias towards negative stimuli that is frequently observed in depressed groups. Audio and video data capture the affective flattening and psychomotor retardation characteristic of depression. Statistical validation confirmed their significant discriminative power in distinguishing depressed from non depressed groups. We address a critical limitation of existing graph-based models that focus on low-frequency information and propose a Multi-Frequency Graph Convolutional Network (MF-GCN). This framework consists of a novel Multi-Frequency Filter Bank Module (MFFBM), which can leverage both low and high frequency signals. Extensive evaluation against traditional machine learning algorithms and deep learning frameworks demonstrates that MF-GCN consistently outperforms baselines. In binary classification, the model achieved a sensitivity of 0.96 and F2 score of 0.94. For the 3 class classification task, the proposed method achieved a sensitivity of 0.79 and specificity of 0.87 and siginificantly suprassed other models. To validate generalizability, the model was also evaluated on the Chinese Multimodal Depression Corpus (CMDC) dataset and achieved a sensitivity of 0.95 and F2 score of 0.96. These results confirm that our trimodal, multi frequency framework effectively captures cross modal interaction for accurate depression detection.

We present a general framework for training spiking neural networks (SNNs) to perform binary classification on multivariate time series, with a focus on step-wise prediction and high precision at low false alarm rates. The approach uses the Evolutionary Optimization of Neuromorphic Systems (EONS) algorithm to evolve sparse, stateful SNNs by jointly optimizing their architectures and parameters. Inputs are encoded into spike trains, and predictions are made by thresholding a single output neuron's spike counts. We also incorporate simple voting ensemble methods to improve performance and robustness. To evaluate the framework, we apply it with application-specific optimizations to the task of detecting low signal-to-noise ratio radioactive sources in gamma-ray spectral data. The resulting SNNs, with as few as 49 neurons and 66 synapses, achieve a 51.8% true positive rate (TPR) at a false alarm rate of 1/hr, outperforming PCA (42.7%) and deep learning (49.8%) baselines. A three-model any-vote ensemble increases TPR to 67.1% at the same false alarm rate. Hardware deployment on the microCaspian neuromorphic platform demonstrates 2mW power consumption and 20.2ms inference latency. We also demonstrate generalizability by applying the same framework, without domain-specific modification, to seizure detection in EEG recordings. An ensemble achieves 95% TPR with a 16% false positive rate, comparable to recent deep learning approaches with significant reduction in parameter count.