Existing state-of-the-art symbolic music generation models predominantly adopt autoregressive or hierarchical autoregressive architectures, modelling symbolic music as a sequence of attribute tokens with unidirectional temporal dependencies, under the assumption of a fixed, strict dependency structure among these attributes. However, we observe that using different attributes as the initial token in these models leads to comparable performance. This suggests that the attributes of a musical note are, in essence, a concurrent and unordered set, rather than a temporally dependent sequence. Based on this insight, we introduce Amadeus, a novel symbolic music generation framework. Amadeus adopts a two-level architecture: an autoregressive model for note sequences and a bidirectional discrete diffusion model for attributes. To enhance performance, we propose Music Latent Space Discriminability Enhancement Strategy(MLSDES), incorporating contrastive learning constraints that amplify discriminability of intermediate music representations. The Conditional Information Enhancement Module (CIEM) simultaneously strengthens note latent vector representation via attention mechanisms, enabling more precise note decoding. We conduct extensive experiments on unconditional and text-conditioned generation tasks. Amadeus significantly outperforms SOTA models across multiple metrics while achieving at least 4$\times$ speed-up. Furthermore, we demonstrate training-free, fine-grained note attribute control feasibility using our model. To explore the upper performance bound of the Amadeus architecture, we compile the largest open-source symbolic music dataset to date, AMD (Amadeus MIDI Dataset), supporting both pre-training and fine-tuning.

Recent advances in large language models (LLMs) and medical LLMs (Med-LLMs) have demonstrated strong performance on general medical benchmarks. However, their capabilities in specialized medical fields, such as dentistry which require deeper domain-specific knowledge, remain underexplored due to the lack of targeted evaluation resources. In this paper, we introduce DentalBench, the first comprehensive bilingual benchmark designed to evaluate and advance LLMs in the dental domain. DentalBench consists of two main components: DentalQA, an English-Chinese question-answering (QA) benchmark with 36,597 questions spanning 4 tasks and 16 dental subfields; and DentalCorpus, a large-scale, high-quality corpus with 337.35 million tokens curated for dental domain adaptation, supporting both supervised fine-tuning (SFT) and retrieval-augmented generation (RAG). We evaluate 14 LLMs, covering proprietary, open-source, and medical-specific models, and reveal significant performance gaps across task types and languages. Further experiments with Qwen-2.5-3B demonstrate that domain adaptation substantially improves model performance, particularly on knowledge-intensive and terminology-focused tasks, and highlight the importance of domain-specific benchmarks for developing trustworthy and effective LLMs tailored to healthcare applications.

One aim of dimensionality reduction is to discover the main factors that explain the data, and as such is paramount to many applications. When working with high dimensional data, autoencoders offer a simple yet effective approach to learn low-dimensional representations. The two components of a general autoencoder consist first of an encoder that maps the observed data onto a latent space; and second a decoder that maps the latent space back to the original observation space, which allows to learn a low-dimensional manifold representation of the original data. In this article, we introduce a new type of geometric regularization for decoding maps approximated by deep neural networks, namely nonlinear conformal regularization . This regularization procedure permits local variations of the decoder map and comes with a new scalar field called conformal factor which acts as a quantitative indicator of the amount of local deformation sustained by the latent space when mapped into the original data space. We also show that this regularization technique allows the computation of the scalar curvature of the learned manifold. Implementation and experiments on the Swiss roll and CelebA datasets are performed to illustrate how to obtain these quantities from the architecture.

Electrocardiogram (ECG) signals serve as a foundational data source for cardiac digital twins, yet their diagnostic utility is frequently compromised by noise and artifacts. To address this issue, we propose TF-TransUNet1D, a novel one-dimensional deep neural network that integrates a U-Net-based encoder-decoder architecture with a Transformer encoder, guided by a hybrid time-frequency domain loss. The model is designed to simultaneously capture local morphological features and long-range temporal dependencies, which are critical for preserving the diagnostic integrity of ECG signals. To enhance denoising robustness, we introduce a dual-domain loss function that jointly optimizes waveform reconstruction in the time domain and spectral fidelity in the frequency domain. In particular, the frequency-domain component effectively suppresses high-frequency noise while maintaining the spectral structure of the signal, enabling recovery of subtle but clinically significant waveform components. We evaluate TF-TransUNet1D using synthetically corrupted signals from the MIT-BIH Arrhythmia Database and the Noise Stress Test Database (NSTDB). Comparative experiments against state-of-the-art baselines demonstrate consistent superiority of our model in terms of SNR improvement and error metrics, achieving a mean absolute error of 0.1285 and Pearson correlation coefficient of 0.9540. By delivering high-precision denoising, this work bridges a critical gap in pre-processing pipelines for cardiac digital twins, enabling more reliable real-time monitoring and personalized modeling.

Psychometric tests, traditionally used to assess humans, are now being applied to Large Language Models (LLMs) to evaluate their behavioral traits. However, existing studies follow a context-free approach, answering each question in isolation to avoid contextual influence. We term this the Disney World test, an artificial setting that ignores real-world applications, where conversational history shapes responses. To bridge this gap, we propose the first Context-Aware Personality Evaluation (CAPE) framework for LLMs, incorporating prior conversational interactions. To thoroughly analyze the influence of context, we introduce novel metrics to quantify the consistency of LLM responses, a fundamental trait in human behavior. Our exhaustive experiments on 7 LLMs reveal that conversational history enhances response consistency via in-context learning but also induces personality shifts, with GPT-3.5-Turbo and GPT-4-Turbo exhibiting extreme deviations. While GPT models are robust to question ordering, Gemini-1.5-Flash and Llama-8B display significant sensitivity. Moreover, GPT models response stem from their intrinsic personality traits as well as prior interactions, whereas Gemini-1.5-Flash and Llama--8B heavily depend on prior interactions. Finally, applying our framework to Role Playing Agents (RPAs) shows context-dependent personality shifts improve response consistency and better align with human judgments. Our code and datasets are publicly available at: https://github.com/jivnesh/CAPE

--The impressive performance of transformer models has sparked the deployment of intelligent applications on resource-constrained edge devices. However, ensuring high-quality service for real-time edge systems is a significant challenge due to the considerable computational demands and resource requirements of these models. Existing strategies typically either offload transformer computations to other devices or directly deploy compressed models on individual edge devices. T o tackle these challenges, we propose a collaborative inference system for general transformer models, termed CoFormer . The central idea behind CoFormer is to exploit the divisibility and integrability of transformer . An off-the-shelf large transformer can be decomposed into multiple smaller models for distributed inference, and their intermediate results are aggregated to generate the final output. We formulate an optimization problem to minimize both inference latency and accuracy degradation under heterogeneous hardware constraints. DeBo algorithm is proposed to first solve the optimization problem to derive the decomposition policy, and then progressively calibrate decomposed models to restore performance. We demonstrate the capability to support a wide range of transformer models on heterogeneous edge devices, achieving up to 3.1 inference speedup with large transformer models. Notably, CoFormer enables the efficient inference of GPT2-XL with 1.6 billion parameters on edge devices, reducing memory requirements by 76.3%. CoFormer can also reduce energy consumption by approximately 40% while maintaining satisfactory inference performance. Guanyu Xu, Zhiwei Hao and Han Hu are with the School of Information and Electrionics, Beijing Institute of Technology, Beijing 100081, China. Li Shen is with the School of Cyber Science and Technology, Shen-zhen Campus of Sun Y at-sen University, Shenzhen 518107, China. Y ong Luo is with the School of Computer Science, National Engineering Research Center for Multimedia Software, Wuhan University, Wuhan 430072, China. Fuhui Sun and Xiaoyan Wang are with Information Technology Service Center of People's Court, Beijing, 100745, China. Y onggang Wen is with the College of Computing and Data Science, Nanyang Technological University, Singapore 639798. CoFormer significantly outperforms other methods. Specifically, CoFormer accelerates inference speed by 3.1 compared to Swin-L [4] with only 1.7% accuracy sacrifice.

Accurately quantifying long-term risk probabilities in diverse stochastic systems is essential for safety-critical control. However, existing sampling-based and partial differential equation (PDE)-based methods often struggle to handle complex varying dynamics. Physics-informed neural networks learn surrogate mappings for risk probabilities from varying system parameters of fixed and finite dimensions, yet can not account for functional variations in system dynamics. To address these challenges, we introduce physics-informed neural operator (PINO) methods to risk quantification problems, to learn mappings from varying \textit{functional} system dynamics to corresponding risk probabilities. Specifically, we propose Neural Spline Operators (NeSO), a PINO framework that leverages B-spline representations to improve training efficiency and achieve better initial and boundary condition enforcements, which are crucial for accurate risk quantification. We provide theoretical analysis demonstrating the universal approximation capability of NeSO. We also present two case studies, one with varying functional dynamics and another with high-dimensional multi-agent dynamics, to demonstrate the efficacy of NeSO and its significant online speed-up over existing methods. The proposed framework and the accompanying universal approximation theorem are expected to be beneficial for other control or PDE-related problems beyond risk quantification.

Although traditional statistical techniques and machine learning methods have contributed significantly to genetics and, in particular, inherited disease diagnosis, they often struggle with complex, high-dimensional data, a challenge now addressed by state-of-the-art deep learning models. Large language models (LLMs), based on transformer architectures, have excelled in tasks requiring contextual comprehension of unstructured medical data. This systematic review examines the role of LLMs in the genetic research and diagnostics of both rare and common diseases. Automated keyword-based search in PubMed, bioRxiv, medRxiv, and arXiv was conducted, targeting studies on LLM applications in diagnostics and education within genetics and removing irrelevant or outdated models. A total of 172 studies were analyzed, highlighting applications in genomic variant identification, annotation, and interpretation, as well as medical imaging advancements through vision transformers. Key findings indicate that while transformer-based models significantly advance disease and risk stratification, variant interpretation, medical imaging analysis, and report generation, major challenges persist in integrating multimodal data (genomic sequences, imaging, and clinical records) into unified and clinically robust pipelines, facing limitations in generalizability and practical implementation in clinical settings. This review provides a comprehensive classification and assessment of the current capabilities and limitations of LLMs in transforming hereditary disease diagnostics and supporting genetic education, serving as a guide to navigate this rapidly evolving field.

This study presents a lightweight, domain-informed AI model for predicting indoor temperatures in naturally ventilated schools and homes in Sub-Saharan Africa. The model extends the Temp-AI-Estimator framework, trained on Tanzanian school data, and evaluated on Nigerian schools and Gambian homes. It achieves robust cross-country performance using only minimal accessible inputs, with mean absolute errors of 1.45°C for Nigerian schools and 0.65°C for Gambian homes. These findings highlight AI's potential for thermal comfort management in resource-constrained environments.

Rapid and reliable qualification of advanced materials remains a bottleneck in industrial manufacturing, particularly for heterogeneous structures produced via non-conventional additive manufacturing processes. This study introduces a novel framework that links microstructure informatics with a range of expert characterization knowledge using customized and hybrid vision-language representations (VLRs). By integrating deep semantic segmentation with pre-trained multi-modal models (CLIP and FLAVA), we encode both visual microstructural data and textual expert assessments into shared representations. To overcome limitations in general-purpose embeddings, we develop a customized similarity-based representation that incorporates both positive and negative references from expert-annotated images and their associated textual descriptions. This allows zero-shot classification of previously unseen microstructures through a net similarity scoring approach. Validation on an additively manufactured metal matrix composite dataset demonstrates the framework's ability to distinguish between acceptable and defective samples across a range of characterization criteria. Comparative analysis reveals that FLAVA model offers higher visual sensitivity, while the CLIP model provides consistent alignment with the textual criteria. Z-score normalization adjusts raw unimodal and cross-modal similarity scores based on their local dataset-driven distributions, enabling more effective alignment and classification in the hybrid vision-language framework. The proposed method enhances traceability and interpretability in qualification pipelines by enabling human-in-the-loop decision-making without task-specific model retraining. By advancing semantic interoperability between raw data and expert knowledge, this work contributes toward scalable and domain-adaptable qualification strategies in engineering informatics.