Head and neck masses are space-occupying lesions that can compress the airway and esophagus and may affect nerves and blood vessels. Available public datasets primarily focus on malignant lesions and often overlook other space-occupying conditions in this region. To address this gap, we introduce MasHeNe, an initial dataset of 3,779 contrast-enhanced CT slices that includes both tumors and cysts with pixel-level annotations. We also establish a benchmark using standard segmentation baselines and report common metrics to enable fair comparison. In addition, we propose the Windowing-Enhanced Mamba with Frequency integration (WEMF) model. WEMF applies tri-window enhancement to enrich the input appearance before feature extraction. It further uses multi-frequency attention to fuse information across skip connections within a U-shaped Mamba backbone. On MasHeNe, WEMF attains the best performance among evaluated methods, with a Dice of 70.45%, IoU of 66.89%, NSD of 72.33%, and HD95 of 5.12 mm. This model indicates stable and strong results on this challenging task. MasHeNe provides a benchmark for head-and-neck mass segmentation beyond malignancy-only datasets. The observed error patterns also suggest that this task remains challenging and requires further research. Our dataset and code are available at https://github.com/drthaodao3101/MasHeNe.git.

We present hls4ml, a free and open-source platform that translates machine learning (ML) models from modern deep learning frameworks into high-level synthesis (HLS) code that can be integrated into full designs for field-programmable gate arrays (FPGAs) or application-specific integrated circuits (ASICs). With its flexible and modular design, hls4ml supports a large number of deep learning frameworks and can target HLS compilers from several vendors, including Vitis HLS, Intel oneAPI and Catapult HLS. Together with a wider eco-system for software-hardware co-design, hls4ml has enabled the acceleration of ML inference in a wide range of commercial and scientific applications where low latency, resource usage, and power consumption are critical. In this paper, we describe the structure and functionality of the hls4ml platform. The overarching design considerations for the generated HLS code are discussed, together with selected performance results.

As Large Language Models (LLMs) continue to scale in parameter count, deploying them on commodity hardware has become increasingly challenging. Post-Training Quantization (PTQ) addresses this by reducing the precision of model weights, typically to 4-bit or lower. However, uniform quantization often leads to significant performance degradation due to the presence of ``outlier features'' -- weights that, while few in number, are critical for maintaining model accuracy. Current state-of-the-art methods such as AWQ (Activation-aware Weight Quantization) and SpQR (Sparse Quantization Representations) rely on calibration data to identify these salient weights via activation magnitudes or Hessian sensitivity. In scenarios where data privacy is paramount or calibration data is unavailable, these methods are inapplicable. In this work, we propose a data-free, structure-aware hypothesis: that the weights identified as Principal Components via Singular Value Decomposition (SVD) are intrinsically important to the model's downstream performance. We introduce a novel selection heuristic that preserves the top-$k$ weights aligned with the principal components in FP32, while aggressively quantizing the residual weights. We compare our method against activation-aware (AWQ) and second-order (SpQR) methods across GLUE benchmarks (MRPC, RTE, QNLI) using a DistilBERT backbone. Our experiments reveal that structural importance is highly correlated with functional importance. On the challenging RTE task, our SVD-based method achieves an accuracy of 66.06\%, outperforming both AWQ (65.34\%) and SpQR (65.34\%) at high protection budgets, validating that intrinsic matrix structure can serve as a robust proxy for weight saliency without the need for forward passes or calibration data.

Medical image segmentation is crucial for clinical diagnosis and treatment planning. Traditional methods typically produce a single segmentation mask, failing to capture inherent uncertainty. Recent generative models enable the creation of multiple plausible masks per image, mimicking the collaborative interpretation of several clinicians. However, these approaches remain computationally heavy. We propose MedSegLatDiff, a diffusion based framework that combines a variational autoencoder (VAE) with a latent diffusion model for efficient medical image segmentation. The VAE compresses the input into a low dimensional latent space, reducing noise and accelerating training, while the diffusion process operates directly in this compact representation. We further replace the conventional MSE loss with weighted cross entropy in the VAE mask reconstruction path to better preserve tiny structures such as small nodules. MedSegLatDiff is evaluated on ISIC-2018 (skin lesions), CVC-Clinic (polyps), and LIDC-IDRI (lung nodules). It achieves state of the art or highly competitive Dice and IoU scores while simultaneously generating diverse segmentation hypotheses and confidence maps. This provides enhanced interpretability and reliability compared to deterministic baselines, making the model particularly suitable for clinical deployment.

Educators frequently rely on diagrams to explain complex concepts during lectures, yet creating clear and complete visual representations in real time while simultaneously speaking can be cognitively demanding. Incomplete or unclear diagrams may hinder student comprehension, as learners must mentally reconstruct missing information while following the verbal explanation. Inspired by advances in code completion tools, we introduce DrawDash, an AI-powered white-board assistant that proactively completes and refines educational diagrams through multimodal understanding. Draw-Dash adopts a T AB-completion interaction model: it listens to spoken explanations, detects intent, and dynamically suggests refinements that can be accepted with a single keystroke. We demonstrate DrawDash across four diverse teaching scenarios--spanning topics from computer science and web development to biology. This work represents an early exploration into reducing instructors' cognitive load and improving diagram-based pedagogy through real-time, speech-driven visual assistance, and concludes with a discussion of current limitations and directions for formal classroom evaluation.

Abstract--The deployment of autonomous AI agents in Internet of Things (IoT) energy systems requires decision-making mechanisms that remain robust, efficient, and trustworthy under real-time constraints and imperfect monitoring. While reinforcement learning enables adaptive prosumer behaviors, ensuring economic consistency and preventing strategic manipulation remain open challenges, particularly when sensing noise or partial observability degrades the operator's ability to verify actions. This paper introduces a trust-enforcement framework for IoT energy trading that combines an α-approximate Vick-rey-Clarke-Groves (VCG) double auction with an immediate one-shot penalty. Unlike reputation-or history-based approaches, the proposed mechanism restores truthful reporting within a single round, even when allocation accuracy is approximate and monitoring is noisy. We theoretically characterize the incentive gap induced by approximation and derive a penalty threshold that guarantees truthful bidding under bounded sensing errors. T o evaluate learning-enabled prosumers, we embed the mechanism into a multi-agent reinforcement learning environment reflecting stochastic generation, dynamic loads, and heterogeneous trading opportunities. Experiments show that improved allocation accuracy consistently reduces deviation incentives, the required penalty matches analytical predictions, and learned bidding behaviors remain stable and interpretable despite imperfect monitoring. These results demonstrate that lightweight penalty designs can reliably align strategic IoT agents with socially efficient energy-trading outcomes. The rapid expansion of the Internet of Things (IoT) has created large-scale networks of heterogeneous sensors, distributed devices, and autonomous software agents that must jointly perceive, reason, and act in dynamic cyber-physical environments. X. Shao and R. Shimizu are with the Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Aichi 441-8580, Japan (e-mail: xun.shao@tut.jp).

Diffusion models have demonstrated strong capabilities for modeling humanlike driving behaviors in autonomous driving, but their iterative sampling process induces substantial latency, and operating directly on raw trajectory points forces the model to spend capacity on low-level kinematics, rather than high-level multi-modal semantics. To address these limitations, we propose LAtent Planner (LAP), a framework that plans in a V AE-learned latent space that disentangles high-level intents from low-level kinematics, enabling our planner to capture rich, multi-modal driving strategies. We further introduce a fine-grained feature distillation mechanism to guide a better interaction and fusion between the high-level semantic planning space and the vectorized scene context. Notably, LAP can produce high-quality plans in one single denoising step, substantially reducing computational overhead. Through extensive evaluations on the large-scale nuPlan benchmark, LAP achieves state-of-the-art closed-loop performance among learning-based planning methods, while demonstrating an inference speedup of at most 10 over previous SOT A approaches. A central challenge is handling the inherent uncertainty and behavioral multimodality of real-world traffic, where multiple distinct yet equally plausible maneuvers may be available (Y ang et al., 2023; Xiao et al., 2020). While early rule-based systems offered interpretability, their hand-crafted logic is brittle and fails to scale to the long-tail of open-world scenarios (Fan et al., 2018; Chen et al., 2024). Consequently, the field has shifted towards data-driven Imitation Learning (IL), which excels at capturing nuanced, human-like behaviors from large-scale datasets (Le Mero et al., 2022; Teng et al., 2022). However, the standard IL objective is notoriously susceptible to mode-averaging, where the model collapses multiple valid expert trajectories into a single, physically infeasible path, fundamentally failing to represent the multi-modal nature of human decision-making (Strohbeck et al., 2020). To overcome this limitation, Denoising Diffusion Probabilistic Models(DDPMs) have emerged as a powerful tool for modeling complex, multi-modal distributions (Liao et al., 2025; Ho et al., 2020). However, existing approaches models directly to raw trajectory waypoints are both computationally inefficient and conceptually flawed. This mirrors the core challenge of early image synthesis: operating in a high-dimensional pixel space expends vast model capacity on low-level details over high-level semantics (Rombach et al., 2022).

Foundation models have revolutionized various fields such as natural language processing (NLP) and computer vision (CV). While efforts have been made to transfer the success of the foundation models in general AI domains to biology, existing works focus on directly adopting the existing foundation model architectures from general machine learning domains without a systematic design considering the unique physicochemical and structural properties of each biological data modality. This leads to suboptimal performance, as these repurposed architectures struggle to capture the long-range dependencies, sparse information, and complex underlying ``grammars'' inherent to biological data. To address this gap, we introduce BioArc, a novel framework designed to move beyond intuition-driven architecture design towards principled, automated architecture discovery for biological foundation models. Leveraging Neural Architecture Search (NAS), BioArc systematically explores a vast architecture design space, evaluating architectures across multiple biological modalities while rigorously analyzing the interplay between architecture, tokenization, and training strategies. This large-scale analysis identifies novel, high-performance architectures, allowing us to distill a set of empirical design principles to guide future model development. Furthermore, to make the best of this set of discovered principled architectures, we propose and compare several architecture prediction methods that effectively and efficiently predict optimal architectures for new biological tasks. Overall, our work provides a foundational resource and a principled methodology to guide the creation of the next generation of task-specific and foundation models for biology.

Recent years have shown that malware attacks still happen with high frequency. Malware experts seek to categorize and classify incoming samples to confirm their trustworthiness or prove their maliciousness. One of the ways in which groups of malware samples can be identified is through malware clustering. Despite the efforts of the community, malware clustering which incorporates benign samples has been under-explored. Moreover, despite the availability of larger public benchmark malware datasets, malware clustering studies have avoided fully utilizing these datasets in their experiments, often resorting to small datasets with only a few families. Additionally, the current state-of-the-art solutions for malware clustering remain unclear. In our study, we evaluate malware clustering quality and establish the state-of-the-art on Bodmas and Ember - two large public benchmark malware datasets. Ours is the first study of malware clustering performed on whole malware benchmark datasets. Additionally, we extend the malware clustering task by incorporating benign samples. Our results indicate that incorporating benign samples does not significantly degrade clustering quality. We find that there are differences in the quality of the created clusters between Ember and Bodmas, as well as a private industry dataset. Contrary to popular opinion, our top clustering performers are K-Means and BIRCH, with DBSCAN and HAC falling behind.

Double perovskites (DPs) are promising candidates for sustainable energy technologies due to their compositional tunability and compatibility with low-energy fabrication, yet their vast design space poses a major challenge for conditional materials discovery. This work introduces a multi-agent, text gradient-driven framework that performs DP composition generation under natural-language conditions by integrating three complementary feedback sources: LLM-based self-evaluation, DP-specific domain knowledge-informed feedback, and ML surrogate-based feedback. Analogous to how knowledge-informed machine learning improves the reliability of conventional data-driven models, our framework incorporates domain-informed text gradients to guide the generative process toward physically meaningful regions of the DP composition space. Systematic comparison of three incremental configurations, (i) pure LLM generation, (ii) LLM generation with LLM reasoning-based feedback, and (iii) LLM generation with domain knowledge-guided feedback, shows that iterative guidance from knowledge-informed gradients improves stability-condition satisfaction without additional training data, achieving over 98% compositional validity and up to 54% stable or metastable candidates, surpassing both the LLM-only baseline (43%) and prior GAN-based results (27%). Analyses of ML-based gradients further reveal that they enhance performance in in-distribution (ID) regions but become unreliable in out-of-distribution (OOD) regimes. Overall, this work provides the first systematic analysis of multi-agent, knowledge-guided text gradients for DP discovery and establishes a generalizable blueprint for MAS-driven generative materials design aimed at advancing sustainable technologies.