Machine learning, and in particular its modern incarnation of deep learning (DL) [1, 2], has become an indispensable tool in particle physics, a field that routinely handles vast datasets and nonlinear relationships among observables [3-6]. In recent years, advances in DL have expanded the scope of data-driven progress across the energy, intensity, accelerator, and cosmic frontiers [7, 8]. Despite remarkable advancements, most current DL applications in particle physics are supervised, relying either on Monte Carlo (MC) simulations or on labeled experimental data. However, because simulations cannot fully capture the complexity of the real world, a persistent gap between MC and Data leads to training bias. Direct training on real data, in turn, demands extensive human labeling, which is labor-intensive and hard to scale [9]. For this reason, the development of unsupervised DL [10, 11] is integral for particle physics. Unsupervised learning has achieved remarkable success in tasks such as clustering [12, 13], anomaly detection [14, 15], and learning representations [16, 17].

We evaluate the performance of various text embedding models and pipeline configurations for AI-driven search systems. We compare sentence-transformer and generative embedding models (e.g., All-MPNet, BGE, GTE, and Qwen) at different dimensions, indexing methods (Milvus HNSW/IVF), and chunking strategies. A custom evaluation dataset of 11,975 query-chunk pairs was synthesized from US City Council meeting transcripts using a local large language model (LLM). The data pipeline includes preprocessing, automated question generation per chunk, manual validation, and continuous integration/continuous deployment (CI/CD) integration. We measure retrieval accuracy using reference-based metrics: Top-K Accuracy and Normalized Discounted Cumulative Gain (NDCG). Our results demonstrate that higher-dimensional embeddings significantly boost search quality (e.g., Qwen3-Embedding-8B/4096 achieves Top-3 accuracy about 0.571 versus 0.412 for GTE-large/1024), and that neural re-rankers (e.g., a BGE cross-encoder) further improve ranking accuracy (Top-3 up to 0.527). Finer-grained chunking (512 characters versus 2000 characters) also improves accuracy. We discuss the impact of these factors and outline future directions for pipeline automation and evaluation.

The interaction between proteins and nucleic acids is crucial for processes that sustain cellular function, including DNA maintenance and the regulation of gene expression and translation. Amino acid mutat ions in protein - nucleic acid complexes often lead to vital disease s . Experimental techniques have their own specific limitations in predicting mutational effects in protein - nucleic acid complexes . In this study, we compiled a large dataset of 1951 mutations including both protein - DNA and protein - RNA complexes and integrate d structural and sequential features to build a deep learning - based regression model named DeepPNI . This model estimates mutation - induced binding free energy changes in protein - nucleic aci d complexes . The structural feature s are encoded via edge - aware RGCN and the sequential feature s are extracted using protein language model ESM - 2. W e have achieved a high average Pearson correlation coeffi cient (PCC) of 0.76 in the large dataset via five - fold cross - validation. Consistent performance across individual dataset of protein - DNA, protein - RNA complexes, and different experimental temperature split dataset make the model g eneralizable . Our model showed g ood performance in complex - based five - fold cross - validation, which prove d its robustness. In addition, DeepPNI outperform ed in e xternal dataset validation, and compar ison with existing tools .

This paper addresses the problem of building global topological maps from 3D LiDAR point clouds for autonomous mobile robots operating in large-scale, dynamic, and unknown environments. Adaptive Resonance Theory-based Topological Clustering with Different Topologies (ATC-DT) builds global topological maps represented as graphs while mitigating catastrophic forgetting during sequential processing. However, its winner selection mechanism relies on an exhaustive nearest-neighbor search over all existing nodes, leading to scalability limitations as the map grows. To address this challenge, we propose a hierarchical extension called Multi-Layer ATC (MLATC). MLATC organizes nodes into a hierarchy, enabling the nearest-neighbor search to proceed from coarse to fine resolutions, thereby drastically reducing the number of distance evaluations per query. The number of layers is not fixed in advance. MLATC employs an adaptive layer addition mechanism that automatically deepens the hierarchy when lower layers become saturated, keeping the number of user-defined hyperparameters low. Simulation experiments on synthetic large-scale environments show that MLATC accelerates topological map building compared to the original ATC-DT and exhibits a sublinear, approximately logarithmic scaling of search time with respect to the number of nodes. Experiments on campus-scale real-world LiDAR datasets confirm that MLATC maintains a millisecond-level per-frame runtime and enables real-time global topological map building in large-scale environments, significantly outperforming the original ATC-DT in terms of computational efficiency.

Multi-modal large language models (MLLMs) have shown promise in advancing healthcare. However, most existing models remain confined to single-image understanding, which greatly limits their applicability in clinical workflows. In practice, medical diagnosis and progression often require synthesizing information across multiple images from different modalities or time points. The development of medical MLLMs capable of such multi-image understanding has been hindered by the lack of large-scale, high-quality annotated training data. To address this limitation, we propose a novel framework that leverages license-permissive compound images in biomedical literature, as a rich yet underutilized data source for multi-image analysis. Specifically, we design a five-stage, context-aware instruction generation paradigm underpinned by a divide-and-conquer strategy. By decomposing multi-image analysis into manageable sub-tasks, this paradigm empowers MLLMs to move beyond single-panel analysis and provide a composite understanding by learning the complex spatial, temporal, and cross-modal relationships inherent in these compound figures. By parsing over 237,000 compound figures and their contextual text for instruction generation, we develop M3LLM, a medical multi-image multi-modal large language model. For benchmarking, we construct PMC-MI-Bench for composite understanding, manually validated by medical experts. Extensive experiments show that M3LLM significantly outperforms both general-purpose and specialized medical MLLMs across multi-image, single-image, text-only, and multi-choice scenarios. Notably, M3LLM exhibits strong generalization to longitudinal chest X-ray analysis using the MIMIC dataset. This work establishes a scalable and efficient paradigm for developing medical MLLMs capable of composite reasoning, bridging the gap between biomedical literature and real-world clinical applications.

Recent advancements in diffusion models have greatly improved text-based image editing, yet methods that edit images independently often produce geometrically and photometrically inconsistent results across different views of the same scene. Such inconsistencies are particularly problematic for editing of 3D representations such as NeRFs or Gaussian Splat models. W e propose a training-free diffusion framework that enforces multi-view consistency during the image editing process. The key assumption is that corresponding points in the unedited images should undergo similar transformations after editing. T o achieve this, we introduce a consistency loss that guides the diffusion sampling toward coherent edits. The framework is flexible and can be combined with widely varying image editing methods, supporting both dense and sparse multi-view editing setups. Experimental results show that our approach significantly improves 3D consistency compared to existing multi-view editing methods. W e also show that this increased consistency enables high-quality Gaussian Splat editing with sharp details and strong fidelity to user-specified text prompts.

The standard theory of model-free reinforcement learning assumes that the environment dynamics are stationary and that agents are decoupled from their environment, such that policies are treated as being separate from the world they inhabit. This leads to theoretical challenges in the multi-agent setting where the non-stationarity induced by the learning of other agents demands prospective learning based on prediction models. To accurately model other agents, an agent must account for the fact that those other agents are, in turn, forming beliefs about it to predict its future behavior, motivating agents to model themselves as part of the environment. Here, building upon foundational work on universal artificial intelligence (AIXI), we introduce a mathematical framework for prospective learning and embedded agency centered on self-prediction, where Bayesian RL agents predict both future perceptual inputs and their own actions, and must therefore resolve epistemic uncertainty about themselves as part of the universe they inhabit. We show that in multi-agent settings, self-prediction enables agents to reason about others running similar algorithms, leading to new game-theoretic solution concepts and novel forms of cooperation unattainable by classical decoupled agents. Moreover, we extend the theory of AIXI, and study universally intelligent embedded agents which start from a Solomonoff prior. We show that these idealized agents can form consistent mutual predictions and achieve infinite-order theory of mind, potentially setting a gold standard for embedded multi-agent learning.

Abstract-- Effective collective decision-making in swarm robotics often requires balancing exploration, communication and individual uncertainty estimation, especially in hazardous environments where direct measurements are limited or costly. We propose a decentralized Bayesian framework that enables a swarm of simple robots to identify the safer of two areas, each characterized by an unknown rate of hazardous events governed by a Poisson process. Robots employ a conjugate prior to gradually predict the times between events and derive confidence estimates to adapt their behavior . Our simulation results show that the robot swarm consistently chooses the correct area while reducing exposure to hazardous events by being sample-efficient. Compared to baseline heuristics, our proposed approach shows better performance in terms of safety and speed of convergence. The proposed scenario has potential to extend the current set of benchmarks in collective decision-making and our method has applications in adaptive risk-aware sampling and exploration in hazardous, dynamic environments. Collective decision-making under uncertainty is a fundamental challenge in multi-robot systems, including domains such as collective perception, environment classification, and spatial consensus [1]-[4]. Decentralized systems (e.g., robot swarms) operate under strict limitations on sensing, communication, and memory. Instead of sharing/storing complete observation histories, robots must maintain compact model representations of their knowledge. It is crucial to develop efficient strategies for collective decision-making, especially when observations are sparse, noisy [5], and gathered from stochastic processes [6]. This is typically characterized as a best-of-n problem [3], [7].

Online pornography and gambling have consistently posed regulatory challenges for governments, threatening both personal assets and privacy. Therefore, it is imperative to research the classification of the newly registered Pornographic and Gambling Domain Names (PGDN). However, scholarly investigation into this topic is limited. Previous efforts in PGDN classification pursue high accuracy using ideal sample data, while others employ up-to-date data from real-world scenarios but achieve lower classification accuracy. This paper introduces the Real-PGDN method, which accomplishes a complete process of timely and comprehensive real-data crawling, feature extraction with feature-missing tolerance, precise PGDN classification, and assessment of application effects in actual scenarios. Our two-level classifier, which integrates CoSENT (BERT-based), Multilayer Perceptron (MLP), and traditional classification algorithms, achieves a 97.88% precision. The research process amasses the NRD2024 dataset, which contains continuous detection information over 20 days for 1,500,000 newly registered domain names across 6 directions. Results from our case study demonstrate that this method also maintains a forecast precision of over 70% for PGDN that are delayed in usage after registration.

Abstract-- This paper presents a novel approach for affordance-informed robotic manipulation by introducing 3D keypoints to enhance the understanding of object parts' functionality. The proposed approach provides direct information about what the potential use of objects is, as well as guidance on where and how a manipulator should engage, whereas conventional methods treat affordance detection as a semantic segmentation task, focusing solely on answering the what question. T o address this gap, we propose a Fusion-based Affordance Keypoint Network (FAKP-Net) by introducing 3D keypoint quadruplet that harnesses the synergistic potential of RGB and Depth image to provide information on execution position, direction, and extent. Benchmark testing demonstrates that FAKP-Net outperforms existing models by significant margins in affordance segmentation task and keypoint detection task. I. INTRODUCTION Autonomous robotic manipulation requires robots to understand the various potential functions of objects and this understanding is referred to as "affordance" [1]. Unlike other properties such as object pose that solely describes the object itself, affordances consider the functional interactions between an object's parts and humans or robots [2]. According to recent studies, the affordance detection for object parts has been approached as a semantic segmentation problem [3], [4], [5], [6], [7], [8], [9], [10] where affordances are predicted by grouping pixels with similar functionality into a single category.