Since the VB algorithm does not depend on the unknown truth to achieve optimality, our results shed light on effective prior choices.

Advances in image registration and machine learning have recently enabled volumetric analysis of postmortem brain tissue from conventional photographs of coronal slabs, which are routinely collected in brain banks and neuropathology laboratories worldwide. One caveat of this methodology is the requirement of segmentation of the tissue from photographs, which currently requires costly manual intervention. In this article, we present a deep learning model to automate this process. The automatic segmentation tool relies on a U-Net architecture that was trained with a combination of 1,414 manually segmented images of both fixed and fresh tissue, from specimens with varying diagnoses, photographed at two different sites. Automated model predictions on a subset of photographs not seen in training were analyzed to estimate performance compared to manual labels, including both inter- and intra-rater variability. Our model achieved a median Dice score over 0.98, mean surface distance under 0.4mm, and 95\% Hausdorff distance under 1.60mm, which approaches inter-/intra-rater levels. Our tool is publicly available at surfer.nmr.mgh.harvard.edu/fswiki/PhotoTools.

Recent advances in Post-Training Quantization (PTQ) techniques have significantly increased demand for serving quantized large language models (LLMs), enabling higher throughput and substantially reduced memory usage with minimal accuracy loss. Quantized models address memory constraints in LLMs and enhance GPU resource utilization through efficient GPU sharing. However, quantized models have smaller KV block sizes than non-quantized models, causing limited memory efficiency due to memory fragmentation. Also, distinct resource usage patterns between quantized and non-quantized models require efficient scheduling to maximize throughput. To address these challenges, we propose FineServe, an inference serving framework for mixed-precision LLMs. FineServe's key contributions include: (1) KV Slab, a precision-aware adaptive memory management technique dynamically allocating KV cache based on model quantization characteristics, significantly reducing GPU memory fragmentation, and (2) a two-level scheduling framework comprising a global scheduler that places models to GPUs based on request rates, latency SLOs, and memory constraints and efficiency, and a local scheduler that adaptively adjusts batch sizes according to real-time request fluctuations. Experimental results demonstrate that FineServe achieves up to 2.2x higher SLO attainment and 1.8x higher token generation throughput compared to the state-of-the-art GPU sharing systems.

Since the VB algorithm does not depend on the unknown truth to achieve optimality, our results shed light on effective prior choices.

Breakthroughs, discoveries, and DIY tips sent every weekday. The relocation of an ice cream parlor in the Polish port town of Gdańsk marked the end of an era. Miś had operated in the same location since 1962, but a few years ago, the ice cream parlor's owners decided to relocate across the city. The vacancy presented local archaeologists with a unique opportunity, however, as the original location in the historic central district of Śródmieście sat above a medieval cemetery attached to Gdańsk's oldest church. Knowing this, experts saw a rare chance to investigate if any history had been hiding underneath all that ice cream.

While the US has precision missiles that can shoot these drones down, they don't always succeed: A drone attack killed three US soldiers and injured dozens more at a base in the Jordanian desert last year. And each American missile costs orders of magnitude more than its targets, which limits their supply; countering thousand-dollar drones with missiles that cost hundreds of thousands, or even millions, of dollars per shot can only work for so long, even with a defense budget that could reach a trillion dollars next year. The US armed forces are now hunting for a solution--and they want it fast. Every branch of the service and a host of defense tech startups are testing out new weapons that promise to disable drones en masse. There are drones that slam into other drones like battering rams; drones that shoot out nets to ensnare quadcopter propellers; precision-guided Gatling guns that simply shoot drones out of the sky; electronic approaches, like GPS jammers and direct hacking tools; and lasers that melt holes clear through a target's side.

Three-dimensional (3D) multi-slab acquisition is a technique frequently employed in high-resolution diffusion-weighted MRI in order to achieve the best signal-to-noise ratio (SNR) efficiency. However, this technique is limited by slab boundary artifacts that cause intensity fluctuations and aliasing between slabs which reduces the accuracy of anatomical imaging. Addressing this issue is crucial for advancing diffusion MRI quality and making high-resolution imaging more feasible for clinical and research applications. In this work, we propose a regularized slab profile encoding (PEN) method within a Plug-and-Play ADMM framework, incorporating multi-scale energy (MuSE) regularization to effectively improve the slab combined reconstruction. Experimental results demonstrate that the proposed method significantly improves image quality compared to non-regularized and TV-regularized PEN approaches. The regularized PEN framework provides a more robust and efficient solution for high-resolution 3D diffusion MRI, potentially enabling clearer, more reliable anatomical imaging across various applications.

This pilot study presents a novel, automated, and scalable methodology for detecting and evaluating subsurface defect-prone regions in concrete slabs using Impact Echo (IE) signal analysis. The approach integrates advanced signal processing, clustering, and visual analytics to identify subsurface anomalies. A unique adaptive thresholding method tailors frequency-based defect identification to the distinct material properties of each slab. The methodology generates frequency maps, binary masks, and k-means cluster maps to automatically classify defect and non-defect regions. Key visualizations, including 3D surface plots, cluster maps, and contour plots, are employed to analyze spatial frequency distributions and highlight structural anomalies. The study utilizes a labeled dataset constructed at the Federal Highway Administration (FHWA) Advanced Sensing Technology Nondestructive Evaluation Laboratory. Evaluations involve ground-truth masking, comparing the generated defect maps with top-view binary masks derived from the information provided by the FHWA. The performance metrics, specifically F1-scores and AUC-ROC, achieve values of up to 0.95 and 0.83, respectively. The results demonstrate the robustness of the methodology, consistently identifying defect-prone areas with minimal false positives and few missed defects. Adaptive frequency thresholding ensures flexibility in addressing variations across slabs, providing a scalable framework for detecting structural anomalies. Additionally, the methodology is adaptable to other frequency-based signals due to its generalizable thresholding mechanism and holds potential for integrating multimodal sensor fusion. This automated and scalable pipeline minimizes manual intervention, ensuring accurate and efficient defect detection, further advancing Non-Destructive Evaluation (NDE) techniques.

Multi-output Gaussian process (MGP) is commonly used as a transfer learning method to leverage information among multiple outputs. A key advantage of MGP is providing uncertainty quantification for prediction, which is highly important for subsequent decision-making tasks. However, traditional MGP may not be sufficiently flexible to handle multivariate data with dynamic characteristics, particularly when dealing with complex temporal correlations. Additionally, since some outputs may lack correlation, transferring information among them may lead to negative transfer. To address these issues, this study proposes a non-stationary MGP model that can capture both the dynamic and sparse correlation among outputs. Specifically, the covariance functions of MGP are constructed using convolutions of time-varying kernel functions. Then a dynamic spike-and-slab prior is placed on correlation parameters to automatically decide which sources are informative to the target output in the training process. An expectation-maximization (EM) algorithm is proposed for efficient model fitting. Both numerical studies and a real case demonstrate its efficacy in capturing dynamic and sparse correlation structure and mitigating negative transfer for high-dimensional time-series data. Finally, a mountain-car reinforcement learning case highlights its potential application in decision making problems.

Message passing neural networks (MPNNs) [18-learn from reference quantum mechanical calculations 21] employ a number of graph convolution layers to communicate and then predict the energy and forces of atomic configurations information between atoms, thereby capturing quickly, thus allowing for a more accurate long-range interaction up to the local cutoff radius times and comprehensive exploration of material and molecular the number of layers. However, if parts of the system are properties at scale [1, 2]. Most state-of-the-art MLIP disconnected on the graph, e.g. two molecules with a distance methods use a short-range approximation: the effective beyond the cutoff, the message passing scheme does potential energy surface experienced by one atom is determined not help. A very interesting approach is the long-distance by its atomic neighborhood.