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Artificial Intelligence, Wearables, & Medicine

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Artificial Intelligence has come into everyone's life in one way or another over the past decade. One of the fastest growing areas using this new technology is the healthcare industry. There have been many advancements over the years and new ways of using it coming out every day. These advancements have even come into light with physicians using data they receive from wearables like smartwatches. Companies like Microsoft and Apple have entire teams dedicated to healthcare.


Israel's Zebra Medical Gets FDA Clearance for Mammography Tool

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Zebra Medical Vision, an Israeli medical imaging analytics company, said on Monday it received clearance from the U.S. Food and Drug Administration for its mammography technology. The company's latest cleared product uses artificial intelligence to prioritize and identify suspicious mammograms. The mammograms are automatically sent to Zebra's platform, where they are processed and analysed for suspected breast lesions. The HealthMammo product then returns its result to the radiologist. It is the company's first oncology tool to receive FDA clearance.


Data secrecy may cripple U.S. attempts to slow pandemic

Science

> Science's COVID-19 reporting is supported by the Pulitzer Center and the Heising-Simons Foundation California was a COVID-19 success story—until suddenly it wasn't. Early in the pandemic, the state seemed to have the new coronavirus under control, but it has begun to ride a wave there, with records set in daily cases several times this month, and deaths on the rise. California officials whose COVID-19 responses were once hailed as enlightened are now receiving criticism—and some of the sharpest is coming from scientists seeking to help guide the state's fight against the virus. Since April, epidemiologists from Stanford University and several University of California (UC) campuses have sought detailed COVID-19 case and contact-tracing data from state and county health authorities for research they hope will point to more effective approaches to slowing the pandemic. “It's a basic mantra of epidemiology and public health: Follow the data” to learn where and how the disease spreads, says Rajiv Bhatia, a physician and epidemiologist who teaches at Stanford and is among those seeking the California data. But the agencies have refused requests filed from April through late June, Science has learned. They cited multiple reasons including workload constraints and privacy concerns—even though records can be deidentified, and federal health privacy rules have been relaxed for research during the pandemic. As a result, Bhatia says, “In 4 months of the epidemic, collecting millions of records, no one in California or at the CDC [U.S. Centers for Disease Control and Prevention] has done the basic epidemiology.” Other states also fail to share highly specific information for their COVID-19 cases, which some scientists warn is hampering efforts to identify targeted measures that could stem the spread of SARS-CoV-2 without full-scale lockdowns. Bhatia and epidemiologists across the country are especially aggrieved after recent news reports revealed states are feeding the same data they desire to a federal contractor, Palantir Technologies, that has drawn criticism for data work supporting Immigration and Customs Enforcement deportations. For a data platform dubbed HHS Protect, Palantir is aggregating information on the spread of the new coronavirus on behalf of the U.S. Department of Health and Human Services (HHS), drawing on more than 225 data sets, including demographic statistics, community-based tests, and a wide range of state-provided data. (This week, sparking concern among public health experts, epidemiologists, and others, HHS also instructed hospitals to provide data on COVID-19 cases and patient information directly to the Palantir system—largely via a second contractor—rather than to CDC as they have for decades.) Aggregated COVID-19 case and death data by county, and often by age and race, are publicly available in much of the country. But few locales link those cases and deaths to other information typically collected on the individuals, such as ZIP codes, occupations, living conditions, and known contacts with others ill with COVID-19. A survey of public data dashboards for all 50 states, Washington, D.C., and Puerto Rico by Prevent Epidemics, a group led by former CDC Director Tom Frieden, found that just 2% of data for 15 key COVID-19 indicators were fully reported. Only 40% of the data were partially reported—with glaring deficiencies for testing and contact tracing. Bhatia and colleagues say that detailed COVID-19 case data could be mined to find factors most responsible for the “biggest bundles of hospitalizations and deaths.” He hypothesizes the data would, for example, confirm that even as commerce opens up, hospitalizations and deaths mostly emerge from familiar flashpoints. He cites care facilities for the elderly and large households that include infected essential workers who are asymptomatic or have mild symptoms; they may then pass the disease to relatives who have risk factors making them more vulnerable to severe illness. “We think you can be more strategic on your interventions if you know where exposures actually occur,” says Jeffrey Klausner, a physician and epidemiologist at UC Los Angeles, who is also seeking his state's data. For example, case data might confirm patchy evidence that indoor dining is risky, but parks and beaches are generally safe. If so, reopening outdoor settings with reasonable precautions might boost the economy and allay fears that severe risk of infection is ubiquitous. As the pandemic evolves, regular reassessment of granular data on cases is vital, says Natalie Dean, a University of Florida (UF) biostatistician. “We have this whole new world now, where we are opening things back up. We have this shifting set of environments—indoor dining, bars, open retail buildings, offices, gyms. When we think of what are pressure points, there's a lot we just don't know yet. … We have to have ‘a learning architecture’ in place where there's always some level of reflection.” In the absence of clear, localized data from public authorities, some clinics in California have done their own research. After conducting thousands of COVID-19 tests in Oakland, “We have been able to pinpoint where some of the outbreaks are, both geographically and in terms of setting,” leading to highly targeted health education and testing outreach, says Noha Aboelata, a physician who heads the city's Roots Community Health Center, which primarily serves people of color in underserved communities. Without neighborhood-level intelligence for public health outreach, you get “a one-size-fits-all solution that might exacerbate the problem,” she says. “Withholding the information is going to lead to deaths.” In response to Science 's questions, the California Department of Public Health wrote that even deidentified data “can be used alone or in combination with publicly available information to identify an individual.” Caitlin Rivers, an epidemiologist at Johns Hopkins University's Center for Health Security, calls reidentification a valid concern, but argues it would happen so rarely that the risk shouldn't justify blanket denials of data requests during the pandemic. “There's a lot of space in the middle that we haven't really explored,” she adds. For example, to obviate some privacy concerns, Bhatia's group requested case reports giving 10-year age ranges rather than specific ages, the week of COVID-19 onset rather than a specific date, and an occupational group rather than specific occupation. To show the value of richer data, Bhatia turned to Florida, which offers fairly detailed information on each of the more than 316,000 COVID-19 cases recorded there so far. The data set enabled him to graph, week by week, infections by age and whether the source of transmission was known. He found that early in the pandemic, the source was known for 80% of children, and 50% to 60% of adults. As Florida relaxed restrictions on businesses and other aspects of life, known sources of transmission remained at similar levels, even though casual contact with strangers was apparently increasing. Because some of the unknown sources of transmission were certainly asymptomatic or mildly symptomatic family or friends, such a finding suggests crowded beaches are playing a smaller role in Florida's surge in infections than, say, increased numbers of large family gatherings at home or repopulated offices. “If people know that 50% or 60% of infections are resulting from people they know, including family, friends, and co-workers, they may better interpret risk,” Bhatia says. Even Florida's data exclude key details that some researchers view as essential to map and respond to the pandemic most effectively—including ZIP codes; more complete racial designations; and specifics on cases in long-term care facilities, jails, and prisons. That hampers targeted responses, says Thomas Hladish, an infectious disease researcher at UF who consulted extensively with state officials about COVID-19 data from March until this month. “A lot of the inconsistencies that you see are reasonably explained by well-intentioned people who are scrambling to reinvent [data fields and formats] on the fly without the appropriate technical background.” The Miami Herald also recently reported that municipal officials have not been able to get the state to provide case details they need to attack local outbreaks. The Florida Department of Health did not respond to Science 's requests for comment. Epidemiologists praise more forthcoming agencies. The New York City Department of Health and Mental Hygiene posts unusually complete, continually updated data sets on COVID-19—showing detailed information on tests, cases, and deaths for 177 discrete neighborhoods—and uses them to map hot spots. It offers probable and confirmed deaths by age, race or ethnicity, underlying conditions, and other factors. One clear finding: Lower income areas, with a higher concentration of large households, suffered from COVID-19 at many times the rate of most wealthy areas. The city's health commissioner, Oxiris Barbot, says the system was crucial in decreasing cases by about 94% and deaths by about 98% since they peaked in April. “The transparency in data helped to paint a picture of how acute a situation we were in and the degree to which we needed New Yorkers to comply with what we were asking them to do,” she says. “It helped highlight as early as possible the ways in which the virus was ravaging Black and brown communities.” And the granular data allowed a calibrated response—including offers of hotel rooms to help people living in crowded conditions isolate when diagnosed with COVID-19. “Had it not been for that data analysis we would have been much slower in the response, and … many more lives would have been lost,” Barbot says. “These are the right type of efforts using the right type of data,” Bhatia says. Figuring out how to stop the pandemic is “the biggest and most impactful policy decision we've seen in our lifetimes,” he adds. But in California and elsewhere, “We're trying to predict the future without analyzing the data that's in front of us. That's a failure.”


How machine learning can improve COVID testing -- GCN

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On June 18, the Food and Drug Administration authorized the use of pooled testing for identifying COVID-19 infections. The method allows up to four swabs to be tested at once – a strategy that is expected to greatly expand frequent testing to larger sections of the population. The idea is that if a bundled sample comes back positive, then all the individuals in that sample will need to be tested separately. If a bundled sample comes back clean, however, that's four people who don't need to be tested further, saving public health officials time and money. The FDA said it expects pooling will allow virus identification with fewer tests, which means more tests could be run at once, fewer testing supplies would be consumed and patients could likely receive results more quickly.


3 Steps to Improve Artificial Intelligence in Healthcare

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Accuracy, precision, recall and other measures of AI efficacy are crucial but not sufficient. Will you use, trust, or make clinical decisions based on a technology that runs on "bad data" and are neither "clinically validated" nor "FDA approved"? From virtual assistants to technologies such as Apple Watch and IBM Watson, several applications of artificial intelligence (AI) have been established to augment health care systems, improve patient care, and assist care-providers. The growing involvement of technology giants such as Google, Apple, and IBM in health care technology have further enhanced the need to understand better the influence of AI on the health care industry. Many health care organizations are employing AI technologies to create new value in the industry.


How AI is enabling COVID-19 research

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In an age of COVID-19, the phrase "business as usual" has nearly lost all meaning for Canadians who have seen their lives disrupted in myriad ways. That includes researchers Jean-Philippe Julien and Costin Antonescu as they work to find antiviral drugs that can fight the disease that is paralyzing countries around the world. "Speed is the key," says Julien, an associate professor in U of T's departments of biochemistry and immunology and a senior scientist in molecular medicine at the Hospital for Sick Children who focuses his work on developing a vaccine for HIV and malaria. "That's what is making research into COVID-19 different. We normally take a linear approach, going step by step, selecting a few candidate drugs or therapies and slowly moving them forward with testing over several years. "But now, with COVID, we all understand that this approach is not possible.


Tabula Rasa HealthCare launches MedWise to prevent adverse drug events

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Tabula Rasa HealthCare today launched MedWise on its PrescribeWellness platform for pharmacists to cumulatively compare how different medications interact with each other. The company, which focuses on improving medication safety, developed this service to allow pharmacists to see how medications will work together on a larger scale than one to one. By doing this, Tabula Rasa says adverse drug events can be reduced. Included with the software is a MedWise Risk Score calculation and MedWise Decision Support. The decision support tool will change the risk score in real time so pharmacists can assess complex medication regimens' safety. Adverse drug events (ADE) cause approximately 1.3 million emergency department visits each year, according to the CDC.


Health: Medtronic Acquires Medicrea, Pioneer in Spine Surgery with AI - Actu IA

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Medtronic and Medicrea announced in a press release that they are in the process of finalizing the acquisition by the US company of the Lyon-based SME. The latter is one of the pioneers in transforming spinal surgery through artificial intelligence, predictive modeling and customized spinal implants. The agreement between the two players will be achieved through the acquisition by Medtronic of all outstanding Medicrea shares. With a focus on predictive medicine, Medicrea designs, manufactures and distributes more than 30 families of FDA-approved implantable devices, which have been used in more than 175,000 surgical procedures worldwide to date. Medicrea is a Lyon-based SME with 175 employees, 35 of whom work in its subsidiary Medicrea USA Corp. based in New York. The company has its own ultra-modern production unit in Lyon, dedicated to the machining and development of custom implants by 3D printing from titanium powder.


FDA clears CINA Head neurovascular imaging artificial intelligence tool

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Medical imaging artificial intelligence (AI) specialist Avicenna.AI has announced it has received 510(k) clearance from the US Food and Drug Administration (FDA) for its CINA Head triage AI solution for neurovascular emergencies. The FDA's decision covers CINA's automatic detection capabilities for both intracranial haemorrhage and large vessel occlusion (LVO) from CT-scan imaging. Stroke is a leading cause of death in the USA, with more than 795,000 strokes resulting in more than 100,000 deaths each year. It is estimated that up to a third of the most common type of stroke are caused by LVO, when a clot blocks the circulation of the blood in the brain. Around one in 10 strokes are thought to be caused by intracranial haemorrhage.


MIM Software Inc. Receives FDA 510(k) Clearance for Deep Learning

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MIM Software Inc., a leading global provider of medical imaging software, announced it has received 510(k) clearance from the US Food and Drug Administration (FDA) for its deep learning auto-contouring software, Contour ProtégéAI . Contour ProtégéAI is an auto-contouring solution that seamlessly integrates into any department's workflow and can be rapidly implemented into virtually any environment. User feedback and a determination to continuously improve auto-segmentation were key drivers in developing the product. "Our customers are under continual pressure to improve their practices while facing escalating time constraints," said Andrew Nelson, Chief Executive Officer of MIM Software Inc. "Our deep learning auto-segmentation product, Contour ProtégéAI, will play a critical role in reducing the burden of contouring." Auto-contouring is an ideal use case for deep learning algorithms because it is one of the most time-consuming clinical tasks.