Large Language Models (LLMs) have transformed natural language processing and hold growing promise for advancing science, healthcare, and decision-making. Yet their training paradigms remain dominated by affirmation-based inference, akin to \textit{modus ponens}, where accepted premises yield predicted consequents. While effective for generative fluency, this one-directional approach leaves models vulnerable to logical fallacies, adversarial manipulation, and failures in causal reasoning. This paper makes two contributions. First, it demonstrates how existing LLMs from major platforms exhibit systematic weaknesses when reasoning in scientific domains with negation, counterexamples, or faulty premises \footnote{Code to recreate these experiments are at https://github.com/hannahdavidsoncollege-maker/ScientificReasoningForEnvironment-MedicineWithLLMs. Second, it introduces a dual-reasoning training framework that integrates affirmative generation with structured counterfactual denial. Grounded in formal logic, cognitive science, and adversarial training, this training paradigm formalizes a computational analogue of ``denying the antecedent'' as a mechanism for disconfirmation and robustness. By coupling generative synthesis with explicit negation-aware objectives, the framework enables models that not only affirm valid inferences but also reject invalid ones, yielding systems that are more resilient, interpretable, and aligned with human reasoning.

The early detection of mental health disorders from social media text is critical for enabling timely support, risk assessment, and referral to appropriate resources. This work introduces multiMentalRoBERTa, a fine-tuned RoBERTa model designed for multiclass classification of common mental health conditions, including stress, anxiety, depression, post-traumatic stress disorder (PTSD), suicidal ideation, and neutral discourse. Drawing on multiple curated datasets, data exploration is conducted to analyze class overlaps, revealing strong correlations between depression and suicidal ideation as well as anxiety and PTSD, while stress emerges as a broad, overlapping category. Comparative experiments with traditional machine learning methods, domain-specific transformers, and prompting-based large language models demonstrate that multiMentalRoBERTa achieves superior performance, with macro F1-scores of 0.839 in the six-class setup and 0.870 in the five-class setup (excluding stress), outperforming both fine-tuned MentalBERT and baseline classifiers. Beyond predictive accuracy, explainability methods, including Layer Integrated Gradients and KeyBERT, are applied to identify lexical cues that drive classification, with a particular focus on distinguishing depression from suicidal ideation. The findings emphasize the effectiveness of fine-tuned transformers for reliable and interpretable detection in sensitive contexts, while also underscoring the importance of fairness, bias mitigation, and human-in-the-loop safety protocols. Overall, multiMentalRoBERTa is presented as a lightweight, robust, and deployable solution for enhancing support in mental health platforms.

Depression and post traumatic stress disorder (PTSD) often co-occur with connected symptoms, complicating automated assessment, which is often binary and disorder specific. Clinically useful diagnosis needs severity aware cross disorder estimates and decision support explanations. Our unified tri modal affective severity framework synchronizes and fuses interview text with sentence level transformer embeddings, audio with log Mel statistics with deltas, and facial signals with action units, gaze, head and pose descriptors to output graded severities for diagnosing both depression (PHQ-8; 5 classes) and PTSD (3 classes). Standardized features are fused via a calibrated late fusion classifier, yielding per disorder probabilities and feature-level attributions. This severity aware tri-modal affective fusion approach is demoed on multi disorder concurrent depression and PTSD assessment. Stratified cross validation on DAIC derived corpora outperforms unimodal/ablation baselines. The fused model matches the strongest unimodal baseline on accuracy and weighted F1, while improving decision curve utility and robustness under noisy or missing modalities. For PTSD specifically, fusion reduces regression error and improves class concordance. Errors cluster between adjacent severities; extreme classes are identified reliably. Ablations show text contributes most to depression severity, audio and facial cues are critical for PTSD, whereas attributions align with linguistic and behavioral markers. Our approach offers reproducible evaluation and clinician in the loop support for affective clinical decision making.

Mental health disorders remain among the leading cause of disability worldwide, yet conditions such as depression, anxiety, and Post-Traumatic Stress Disorder (PTSD) are frequently underdiagnosed or misdiagnosed due to subjective assessments, limited clinical resources, and stigma and low awareness. In primary care settings, studies show that providers misidentify depression or anxiety in over 60% of cases, highlighting the urgent need for scalable, accessible, and context-aware diagnostic tools that can support early detection and intervention. In this study, we evaluate the effectiveness of machine learning models for mental health screening using a unique dataset of 553 real-world, semistructured interviews, each paried with ground-truth diagnoses for major depressive episodes (MDE), anxiety disorders, and PTSD. We benchmark multiple model classes, including zero-shot prompting with GPT-4.1 Mini and MetaLLaMA, as well as fine-tuned RoBERTa models using LowRank Adaptation (LoRA). Our models achieve over 80% accuracy across diagnostic categories, with especially strongperformance on PTSD (up to 89% accuracy and 98% recall). We also find that using shorter context, focused context segments improves recall, suggesting that focused narrative cues enhance detection sensitivity. LoRA fine-tuning proves both efficient and effective, with lower-rank configurations (e.g., rank 8 and 16) maintaining competitive performance across evaluation metrics. Our results demonstrate that LLM-based models can offer substantial improvements over traditional self-report screening tools, providing a path toward low-barrier, AI-powerd early diagnosis. This work lays the groundwork for integrating machine learning into real-world clinical workflows, particularly in low-resource or high-stigma environments where access to timely mental health care is most limited.

Beirut, Lebanon – By the time Zainab Dhaher and her family fled their southern Lebanese village last September, Israeli shelling had become relentless. They packed what they could and drove 13 hours to Beirut, only to find themselves once again within range of Israeli bombardment. The cycle of displacement repeated. I didn't have time to pack clothes for my children," the 34-year-old mother of two recalls, her voice cracking during a phone interview. "We moved from place to place, and no one helped us. Months after a United States-brokered ceasefire took effect in November, the fear still lingers.

Recent research has focused on designing neural samplers that amortize the process of sampling from unnormalized densities. However, despite significant advancements, they still fall short of the state-of-the-art MCMC approach, Parallel Tempering (PT), when it comes to the efficiency of target evaluations. On the other hand, unlike a well-trained neural sampler, PT yields only dependent samples and needs to be rerun -- at considerable computational cost -- whenever new samples are required. To address these weaknesses, we propose the Progressive Tempering Sampler with Diffusion (PTSD), which trains diffusion models sequentially across temperatures, leveraging the advantages of PT to improve the training of neural samplers. We also introduce a novel method to combine high-temperature diffusion models to generate approximate lower-temperature samples, which are minimally refined using MCMC and used to train the next diffusion model. PTSD enables efficient reuse of sample information across temperature levels while generating well-mixed, uncorrelated samples. Our method significantly improves target evaluation efficiency, outperforming diffusion-based neural samplers.

Post - Traumatic Stress Disorder (PTSD) remains underdiagnosed in clinical settings, presenting opportunities for automated detection to identify patients . This study evaluates natural language processing approaches for detecting PTSD from clinical interview transcripts. We compared general and mental health - specific transformer models (BERT/RoBERTa), embedding - based methods (SentenceBERT/ LLaMA), and large language model prompting strategies (zero - shot/few - shot/chain - of - thought) using the DAIC - WOZ dataset. Do main - specific models significantly outperformed general models (Mental - RoBERTa F1=0.643 vs. RoBERTa - base 0.485) . LLaMA embeddings with neural networks achieved the highest performance (F1=0.700) . Zero - shot prompting using DSM - 5 criteria yielded competitive results without training data (F1=0.657 Performance varied significantly across symptom severity and comorbidity status, with higher accuracy for severe PTSD cases and patients with comorbid depression. Our findings highlight the potential of domain - adapted embeddings and LLMs for scalable scr eening while underscoring the need for improved detection of nuanced presentations and offering insights for developing clinically viable AI tools for PTSD assessment . Introduction Post - Traumatic Stress Disorder (PTSD) affects approximately 6% of the U.S. population, with significantly higher rates among veterans and trauma survivors. Despite its prevalence, PTSD remains underdiagnosed in primary care settings, with studies suggesting that around 30 % of cases go unrecognized.

We propose a novel dual-loop system that synergistically combines responsive neurostimulation (RNS) implants with artificial intelligence-driven wearable devices for treating post-traumatic stress disorder (PTSD) and enabling naturalistic brain research. In PTSD Therapy Mode, an implanted closed-loop neural device monitors amygdala activity and provides on-demand stimulation upon detecting pathological theta oscillations, while an ensemble of wearables (smart glasses, smartwatches, smartphones) uses multimodal large language model (LLM) analysis of sensory data to detect environmental or physiological PTSD triggers and deliver timely audiovisual interventions. Logged events from both the neural and wearable loops are analyzed to personalize trigger detection and progressively transition patients to non-invasive interventions. In Neuroscience Research Mode, the same platform is adapted for real-world brain activity capture. Wearable-LLM systems recognize naturalistic events (social interactions, emotional situations, compulsive behaviors, decision making) and signal implanted RNS devices (via wireless triggers) to record synchronized intracranial data during these moments. This approach builds on recent advances in mobile intracranial EEG recording and closed-loop neuromodulation in humans (BRAIN Initiative, 2023) (Mobbs et al., 2021). We discuss how our interdisciplinary system could revolutionize PTSD therapy and cognitive neuroscience by enabling 24/7 monitoring, context-aware intervention, and rich data collection outside traditional labs. The vision is a future where AI-enhanced devices continuously collaborate with the human brain, offering therapeutic support and deep insights into neural function, with the resulting real-world context rich neural data, in turn, accelerating the development of more biologically-grounded and human-centric AI.

-- Individuals' general well - being is greatly impacted by mental health conditions including depression and Post - Traumatic Stress Disorder (PTSD), underscoring the importance of early detection and precise diagnosis in order to facilitate prompt clinical in tervention. An advanced multimodal deep learning system for the automated classification of PTSD and depression is presented in this paper. Utilizing textual and audio data from clinical interview datasets, the method com - bines features taken from both mo dalities by combining the architectures of LSTM (Long Short - Term Memory) and BiLSTM (Bidirectional Long Short - Term Memory).Although text features focus on speech's semantic and grammatical components; audio features capture vocal traits including rhythm, t one, and pitch. This combination of modalities enhances the model's capacity to identify minute patterns connected to mental health conditions. Using test datasets, the proposed method achieves classification accuracies of 92% for depression and 93% for PT SD, outper - forming traditional unimodal approaches and demonstrating its accuracy and robustness. In addi - tion to lowering people's quality of life, many illnesses have a significant negative impact on society and the economy. If not treated or recognized, mental health issues can lead to chronic diseases, decreased functioning, and even higher death rates. In under - resourced areas mental health issues are prevalent, even with advancements in clinical practice, traditional methods of diagnosing these disorders -- such as psychological testing and in - person interviews -- are still limited due to their subjective nature, resource - intensive nature, and reliance on the availabil - ity of qualified healthcare professionals.

Mental health disorders are increasingly prevalent worldwide, creating an urgent need for innovative tools to support early diagnosis and intervention. This study explores the potential of Large Language Models (LLMs) in multimodal mental health diagnostics, specifically for detecting depression and Post Traumatic Stress Disorder through text and audio modalities. Using the E-DAIC dataset, we compare text and audio modalities to investigate whether LLMs can perform equally well or better with audio inputs. We further examine the integration of both modalities to determine if this can enhance diagnostic accuracy, which generally results in improved performance metrics. Our analysis specifically utilizes custom-formulated metrics; Modal Superiority Score and Disagreement Resolvement Score to evaluate how combined modalities influence model performance. The Gemini 1.5 Pro model achieves the highest scores in binary depression classification when using the combined modality, with an F1 score of 0.67 and a Balanced Accuracy (BA) of 77.4%, assessed across the full dataset. These results represent an increase of 3.1% over its performance with the text modality and 2.7% over the audio modality, highlighting the effectiveness of integrating modalities to enhance diagnostic accuracy. Notably, all results are obtained in zero-shot inferring, highlighting the robustness of the models without requiring task-specific fine-tuning. To explore the impact of different configurations on model performance, we conduct binary, severity, and multiclass tasks using both zero-shot and few-shot prompts, examining the effects of prompt variations on performance. The results reveal that models such as Gemini 1.5 Pro in text and audio modalities, and GPT-4o mini in the text modality, often surpass other models in balanced accuracy and F1 scores across multiple tasks.