As rates of mental health conditions like depression spike, we desperately need new ways of identifying and treating people in distress. The last big breakthrough in treating depression was all the way back in the 1980s. That was when Prozac, the first SSRI antidepressant, was released. It and its subsequent copycats soon swept the globe, and hundreds of millions of people have now taken this kind of medication. But while three-quarters of people say the pills have helped them feel better, they don't work for everyone.

"It seems like this past week has been quite challenging for you," a disembodied voice tells me, before proceeding to ask a series of increasingly personal questions. "Have you been feeling down or depressed?" "Can you describe what this feeling has been like for you?" "Does the feeling lift at all when something good happens?" When I respond to each one, my chatbot interviewer thanks me for my honesty and empathises with any issues. By the end of the conversation, I will have also spoken about my sleep patterns, sex drive and appetite for food.

Four new books grapple with a global mental-health crisis and the dawn of algorithmic therapy. A technician adjusts the wiring inside the Mark I Perceptron. This early AI system was designed not by a mathematician but by a psychologist. More than a billion people worldwide suffer from a mental-health condition, according to the World Health Organization. The prevalence of anxiety and depression is growing in many demographics, particularly young people, and suicide is claiming hundreds of thousands of lives globally each year. Given the clear demand for accessible and affordable mental-health services, it's no wonder that people have looked to artificial intelligence for possible relief.

Purpose To conduct a systematic review of machine learning models for predicting violent behaviour by synthesising and appraising their validity, usefulness, and performance. Methods We systematically searched nine bibliographic databases and Google Scholar up to September 2025 for development and/or validation studies on machine learning methods for predicting all forms of violent behaviour. We synthesised the results by summarising discrimination and calibration performance statistics and evaluated study quality by examining risk of bias and clinical utility. Results We identified 38 studies reporting the development and validation of 40 models. Most studies reported Area Under the Curve (AUC) as the discrimination statistic with a range of 0.68-0.99. Only eight studies reported calibration performance, and three studies reported external validation. 31 studies had a high risk of bias, mainly in the analysis domain, and three studies had low risk of bias. The overall clinical utility of violence prediction models is poor, as indicated by risks of overfitting due to small samples, lack of transparent reporting, and low generalisability. Conclusion Although black box machine learning models currently have limited applicability in clinical settings, they may show promise for identifying high-risk individuals. We recommend five key considerations for violence prediction modelling: (i) ensuring methodological quality (e.g. following guidelines) and interdisciplinary collaborations; (ii) using black box algorithms only for highly complex data; (iii) incorporating dynamic predictions to allow for risk monitoring; (iv) developing more trustworthy algorithms using explainable methods; and (v) applying causal machine learning approaches where appropriate.

In this study, we present AttentiveGRUAE, a novel attention-based gated recurrent unit (GRU) autoencoder designed for temporal clustering and prediction of outcome from longitudinal wearable data. Our model jointly optimizes three objectives: (1) learning a compact latent representation of daily behavioral features via sequence reconstruction, (2) predicting end-of-period depression rate through a binary classification head, and (3) identifying behavioral subtypes through Gaussian Mixture Model (GMM) based soft clustering of learned embeddings. We evaluate AttentiveGRUAE on longitudinal sleep data from 372 participants (GLOBEM 2018-2019), and it demonstrates superior performance over baseline clustering, domain-aligned self-supervised, and ablated models in both clustering quality (silhouette score = 0.70 vs 0.32-0.70) and depression classification (AUC = 0.74 vs 0.50-0.67). Additionally, external validation on cross-year cohorts from 332 participants (GLOBEM 2020-2021) confirms cluster reproducibility (silhouette score = 0.63, AUC = 0.61) and stability. We further perform subtype analysis and visualize temporal attention, which highlights sleep-related differences between clusters and identifies salient time windows that align with changes in sleep regularity, yielding clinically interpretable explanations of risk.

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Explainable Artificial Intelligence (XAI) has been presented as the critical component for unlocking the potential of machine learning in mental health screening (MHS). However, a persistent lab-to-clinic gap remains. Current XAI techniques, such as SHAP and LIME, excel at producing technically faithful outputs such as feature importance scores, but fail to deliver clinically relevant, actionable insights that can be used by clinicians or understood by patients. This disconnect between technical transparency and human utility is the primary barrier to real-world adoption. This paper argues that this gap is a translation problem and proposes the Generative Operational Framework, a novel system architecture that leverages Large Language Models (LLMs) as a central translation engine. This framework is designed to ingest the raw, technical outputs from diverse XAI tools and synthesize them with clinical guidelines (via RAG) to automatically generate human-readable, evidence-backed clinical narratives. To justify our solution, we provide a systematic analysis of the components it integrates, tracing the evolution from intrinsic models to generative XAI. We demonstrate how this framework directly addresses key operational barriers, including workflow integration, bias mitigation, and stakeholder-specific communication. This paper also provides a strategic roadmap for moving the field beyond the generation of isolated data points toward the delivery of integrated, actionable, and trustworthy AI in clinical practice.

Antidepressant nonadherence is pervasive, driving relapse, hospitalization, suicide risk, and billions in avoidable costs. Clinicians need tools that detect adherence lapses promptly, yet current methods are either invasive (serum assays, neuroimaging) or proxy-based and inaccurate (pill counts, pharmacy refills). We present the first noninvasive biomarker that detects antidepressant intake from a single night of sleep. A transformer-based model analyzes sleep data from a consumer wearable or contactless wireless sensor to infer antidepressant intake, enabling remote, effortless, daily adherence assessment at home. Across six datasets comprising 62,000 nights from >20,000 participants (1,800 antidepressant users), the biomarker achieved AUROC = 0.84, generalized across drug classes, scaled with dose, and remained robust to concomitant psychotropics. Longitudinal monitoring captured real-world initiation, tapering, and lapses. This approach offers objective, scalable adherence surveillance with potential to improve depression care and outcomes.

Static solutions don't serve a dynamic mind. Thus, we advocate a shift from static mental health diagnostic assessments to continuous, artificial intelligence (AI)-driven assessment. Focusing on Attention-Deficit/Hyperactivity Disorder (ADHD) as a case study, we explore how generative AI has the potential to address current capacity constraints in neuropsychology, potentially enabling more personalized and longitudinal care pathways. In particular, AI can efficiently conduct frequent, low-level experience sampling from patients and facilitate diagnostic reconciliation across care pathways. We envision a future where mental health care benefits from continuous, rich, and patient-centered data sampling to dynamically adapt to individual patient needs and evolving conditions, thereby improving both accessibility and efficacy of treatment. We further propose the use of mental health digital twins (MHDTs) - continuously updated computational models that capture individual symptom dynamics and trajectories - as a transformative framework for personalized mental health care. We ground this framework in empirical evidence and map out the research agenda required to refine and operationalize it.

Autism and Attention-Deficit Hyperactivity Disorder (ADHD) are two of the most commonly observed neurodevelopmental conditions in childhood. Providing a specific computational assessment to distinguish between the two can prove difficult and time intensive. Given the high prevalence of their co-occurrence, there is a need for scalable and accessible methods for distinguishing the co-occurrence of autism and ADHD from individual diagnoses. The first step is to identify a core set of features that can serve as the basis for behavioral feature extraction. We trained machine learning models on data from the National Survey of Children's Health to identify behaviors to target as features in automated clinical decision support systems. A model trained on the binary task of distinguishing either developmental delay (autism or ADHD) vs. neither achieved sensitivity >92% and specificity >94%, while a model trained on the 4-way classification task of autism vs. ADHD vs. both vs. none demonstrated >65% sensitivity and >66% specificity. While the performance of the binary model was respectable, the relatively low performance in the differential classification of autism and ADHD highlights the challenges that persist in achieving specificity within clinical decision support tools for developmental delays. Nevertheless, this study demonstrates the potential of applying behavioral questionnaires not traditionally used for clinical purposes towards supporting digital screening assessments for pediatric developmental delays.