Designing therapeutic peptides with tailored properties is hindered by the vastness of sequence space, limited experimental data, and poor interpretability of current generative models. To address these challenges, we introduce PepThink-R1, a generative framework that integrates large language models (LLMs) with chain-of-thought (CoT) supervised fine-tuning and reinforcement learning (RL). Unlike prior approaches, PepThink-R1 explicitly reasons about monomer-level modifications during sequence generation, enabling interpretable design choices while optimizing for multiple pharmacological properties. Guided by a tailored reward function balancing chemical validity and property improvements, the model autonomously explores diverse sequence variants. We demonstrate that PepThink-R1 generates cyclic peptides with significantly enhanced lipophilicity, stability, and exposure, outperforming existing general LLMs (e.g., GPT-5) and domain-specific baseline in both optimization success and interpretability. To our knowledge, this is the first LLM-based peptide design framework that combines explicit reasoning with RL-driven property control, marking a step toward reliable and transparent peptide optimization for therapeutic discovery.

In Autonomous Driving Systems (ADS), Directed Acyclic Graphs (DAGs) are widely used to model complex data dependencies and inter-task communication. However, existing DAG scheduling approaches oversimplify data fusion tasks by assuming fixed triggering mechanisms, failing to capture the diverse fusion patterns found in real-world ADS software stacks. In this paper, we propose a systematic framework for analyzing various fusion patterns and their performance implications in ADS. Our framework models three distinct fusion task types: timer-triggered, wait-for-all, and immediate fusion, which comprehensively represent real-world fusion behaviors. Our Integer Linear Programming (ILP)-based approach enables an optimization of multiple real-time performance metrics, including reaction time, time disparity, age of information, and response time, while generating deterministic offline schedules directly applicable to real platforms. Evaluation using real-world ADS case studies, Raspberry Pi implementation, and randomly generated DAGs demonstrates that our framework handles diverse fusion patterns beyond the scope of existing work, and achieves substantial performance improvements in comparable scenarios.

Multimodal instruction tuning has proven to be an effective strategy for achieving zero-shot generalization by fine-tuning pre-trained Large Multimodal Models (LMMs) with instruction-following data. However, as the scale of LMMs continues to grow, fully fine-tuning these models has become highly parameter-intensive. Although Parameter-Efficient Fine-Tuning (PEFT) methods have been introduced to reduce the number of tunable parameters, a significant performance gap remains compared to full fine-tuning. Furthermore, existing PEFT approaches are often highly parameterized, making them difficult to interpret and control. In light of this, we introduce Multimodal Representation Tuning (MRT), a novel approach that focuses on directly editing semantically rich multimodal representations to achieve strong performance and provide intuitive control over LMMs. Empirical results show that our method surpasses current state-of-the-art baselines with significant performance gains (e.g., 1580.40 MME score) while requiring substantially fewer tunable parameters (e.g., 0.03% parameters). Additionally, we conduct experiments on editing instrumental tokens within multimodal representations, demonstrating that direct manipulation of these representations enables simple yet effective control over network behavior.

Training models to effectively use test-time compute is crucial for improving the reasoning performance of LLMs. Current methods mostly do so via fine-tuning on search traces or running RL with 0/1 outcome reward, but do these approaches efficiently utilize test-time compute? Would these approaches continue to scale as the budget improves? In this paper, we try to answer these questions. We formalize the problem of optimizing test-time compute as a meta-reinforcement learning (RL) problem, which provides a principled perspective on spending test-time compute. This perspective enables us to view the long output stream from the LLM as consisting of several episodes run at test time and leads us to use a notion of cumulative regret over output tokens as a way to measure the efficacy of test-time compute. Akin to how RL algorithms can best tradeoff exploration and exploitation over training, minimizing cumulative regret would also provide the best balance between exploration and exploitation in the token stream. While we show that state-of-the-art models do not minimize regret, one can do so by maximizing a dense reward bonus in conjunction with the outcome 0/1 reward RL. This bonus is the ''progress'' made by each subsequent block in the output stream, quantified by the change in the likelihood of eventual success. Using these insights, we develop Meta Reinforcement Fine-Tuning, or MRT, a new class of fine-tuning methods for optimizing test-time compute. MRT leads to a 2-3x relative gain in performance and roughly a 1.5x gain in token efficiency for math reasoning compared to outcome-reward RL.

Ensuring thermal comfort is essential for the well-being and productivity of individuals in built environments. Of the various thermal comfort indicators, the mean radiant temperature (MRT) is very challenging to measure. Most common measurement methodologies are time-consuming and not user-friendly. To address this issue, this paper proposes a novel MRT measurement framework that uses visual simultaneous localization and mapping (SLAM) and semantic segmentation techniques. The proposed approach follows the rule of thumb of the traditional MRT calculation method using surface temperature and view factors. However, it employs visual SLAM and creates a 3D thermal point cloud with enriched surface temperature information. The framework then implements Grounded SAM, a new object detection and segmentation tool to extract features with distinct temperature profiles on building surfaces. The detailed segmentation of thermal features not only reduces potential errors in the calculation of the MRT but also provides an efficient reconstruction of the spatial MRT distribution in the indoor environment. We also validate the calculation results with the reference measurement methodology. This data-driven framework offers faster and more efficient MRT measurements and spatial mapping than conventional methods. It can enable the direct engagement of researchers and practitioners in MRT measurements and contribute to research on thermal comfort and radiant cooling and heating systems.

Automatic metrics play a crucial role in machine translation. Despite the widespread use of n-gram-based metrics, there has been a recent surge in the development of pre-trained model-based metrics that focus on measuring sentence semantics. However, these neural metrics, while achieving higher correlations with human evaluations, are often considered to be black boxes with potential biases that are difficult to detect. In this study, we systematically analyze and compare various mainstream and cutting-edge automatic metrics from the perspective of their guidance for training machine translation systems. Through Minimum Risk Training (MRT), we find that certain metrics exhibit robustness defects, such as the presence of universal adversarial translations in BLEURT and BARTScore. In-depth analysis suggests two main causes of these robustness deficits: distribution biases in the training datasets, and the tendency of the metric paradigm. By incorporating token-level constraints, we enhance the robustness of evaluation metrics, which in turn leads to an improvement in the performance of machine translation systems. Codes are available at \url{https://github.com/powerpuffpomelo/fairseq_mrt}.

In many machine learning scenarios, supervision by gold labels is not available and consequently neural models cannot be trained directly by maximum likelihood estimation (MLE). In a weak supervision scenario, metric-augmented objectives can be employed to assign feedback to model outputs, which can be used to extract a supervision signal for training. We present several objectives for two separate weakly supervised tasks, machine translation and semantic parsing. We show that objectives should actively discourage negative outputs in addition to promoting a surrogate gold structure. This notion of bipolarity is naturally present in ramp loss objectives, which we adapt to neural models. We show that bipolar ramp loss objectives outperform other non-bipolar ramp loss objectives and minimum risk training (MRT) on both weakly supervised tasks, as well as on a supervised machine translation task. Additionally, we introduce a novel token-level ramp loss objective, which is able to outperform even the best sequence-level ramp loss on both weakly supervised tasks.

Over 200 attendees attended the blockchain meetup in Istanbul, Turkey co-organized by SamuraiSignals and MATRIX AI Network on July 28th, to explore leading edge developments in blockchain. In his talk, IDA cofounder, Mr. Walter Wang outlined four innovations shaping the future of asset digitization. Wang said that the technical basis for asset digitization, is creating a digitized representation of real assets or IP assets in a binary code format -- however, there are currently the following challenges to overcome before the technology can be applied widely. There is an asymmetry in transparency of asset information. How to extend legal protections to digital assets?