Learning models over factorized joins avoids redundant computations by identifying and pre-computing shared cofactors. Previous work has investigated the performance gain when computing cofactors on traditional disk-based database systems. Due to the absence of published code, the experiments could not be reproduced on in-memory database systems. This work describes the implementation when using cofactors for in-database factorized learning. We benchmark our open-source implementation for learning linear regression on factorized joins with PostgreSQL -- as a disk-based database system -- and HyPer -- as an in-memory engine. The evaluation shows a performance gain of factorized learning on in-memory database systems by 70\% to non-factorized learning and by a factor of 100 compared to disk-based database systems. Thus, modern database engines can contribute to the machine learning pipeline by pre-computing aggregates prior to data extraction to accelerate training.

We introduce the STATION, an open-world multi-agent environment for autonomous scientific discovery. The Station simulates a complete scientific ecosystem, where agents can engage in long scientific journeys that include reading papers from peers, formulating hypotheses, collaborating with peers, submitting experiments, and publishing results. Importantly, there is no centralized system coordinating their activities. Utilizing their long context, agents are free to choose their own actions and develop their own narratives within the Station. Experiments demonstrate that AI agents in the Station achieve new state-of-the-art performance on a wide range of benchmarks, spanning mathematics, computational biology, and machine learning, notably surpassing AlphaEvolve in circle packing. A rich tapestry of unscripted narratives emerges, such as agents collaborating and analyzing other works rather than pursuing myopic optimization. From these emergent narratives, novel methods arise organically, such as a new density-adaptive algorithm for scRNA-seq batch integration that borrows concepts from another domain. The Station marks a first step towards autonomous scientific discovery driven by emergent behavior in an open-world environment, representing a new paradigm that moves beyond rigid pipelines.

Agentic AI represents a transformative shift in artificial intelligence, but its rapid advancement has led to a fragmented understanding, often conflating modern neural systems with outdated symbolic models -- a practice known as conceptual retrofitting. This survey cuts through this confusion by introducing a novel dual-paradigm framework that categorizes agentic systems into two distinct lineages: the Symbolic/Classical (relying on algorithmic planning and persistent state) and the Neural/Generative (leveraging stochastic generation and prompt-driven orchestration). Through a systematic PRISMA-based review of 90 studies (2018--2025), we provide a comprehensive analysis structured around this framework across three dimensions: (1) the theoretical foundations and architectural principles defining each paradigm; (2) domain-specific implementations in healthcare, finance, and robotics, demonstrating how application constraints dictate paradigm selection; and (3) paradigm-specific ethical and governance challenges, revealing divergent risks and mitigation strategies. Our analysis reveals that the choice of paradigm is strategic: symbolic systems dominate safety-critical domains (e.g., healthcare), while neural systems prevail in adaptive, data-rich environments (e.g., finance). Furthermore, we identify critical research gaps, including a significant deficit in governance models for symbolic systems and a pressing need for hybrid neuro-symbolic architectures. The findings culminate in a strategic roadmap arguing that the future of Agentic AI lies not in the dominance of one paradigm, but in their intentional integration to create systems that are both adaptable and reliable. This work provides the essential conceptual toolkit to guide future research, development, and policy toward robust and trustworthy hybrid intelligent systems.

Positive selection drives the emergence of adaptive mutations in Mycobacterium tuberculosis, shaping drug resistance, transmissibility, and virulence. Phylogenetic trees capture evolutionary relationships among isolates and provide a natural framework for detecting such adaptive signals. We present a phylogeny-guided graph attention network (GAT) approach, introducing a method for converting SNP-annotated phylogenetic trees into graph structures suitable for neural network analysis. Using 500 M. tuberculosis isolates from four major lineages and 249 single-nucleotide variants (84 resistance-associated and 165 neutral) across 61 drug-resistance genes, we constructed graphs where nodes represented isolates and edges reflected phylogenetic distances. Edges between isolates separated by more than seven internal nodes were pruned to emphasise local evolutionary structure. Node features encoded SNP presence or absence, and the GAT architecture included two attention layers, a residual connection, global attention pooling, and a multilayer perceptron classifier. The model achieved an accuracy of 0.88 on a held-out test set and, when applied to 146 WHO-classified "uncertain" variants, identified 41 candidates with convergent emergence across multiple lineages, consistent with adaptive evolution. This work demonstrates the feasibility of transforming phylogenies into GNN-compatible structures and highlights attention-based models as effective tools for detecting positive selection, aiding genomic surveillance and variant prioritisation.

Fingerprinting Large Language Models (LLMs) is essential for provenance verification and model attribution. LLM fingerprints have recently been proposed as a tool to identify, attribute, and trace LLMs by examining their observable behaviors (Pasquini et al., 2024; Xu et al., 2024; Y oon et al., 2025; Galton's Finger Prints (1892) (Galton, 1892): "A fingerprint is the pattern formed by friction-ridge skin on the fingertips; They are defined only after models have been fully trained and converged (finish pretaining), e.g., extracting patterns from parameters or generated text, and thus capture traits that emerge as the In this work, we propose a stricter notion of an LLM fingerprint: an intrinsic property present at model initialization and detectable at any time of the subsequent training. Extensive experiments in Section 5.1 show that our method can even distinguish between models that differ only in their initialization seed, despite an identical training pipeline and data order. Finally, in Section 5.2, we evaluate our method both Classic techniques include backdoor attacks (Adi et al., 2018; Nasery et al.); and model weight watermarks, which embed identifiers into parameters or link them With white-box access, signatures are extracted from model weights, leveraging intrinsic properties like the distribution of attention matrices (Y oon et al., 2025), the kernel alignment of internal representations (Zhang et al., 2024), or the stable direction of parameter vectors. Figure 1: Initialization-born token bias persists through training.

Enterprise data pipelines, characterized by complex transformations across multiple programming languages, often cause a semantic disconnect between original metadata and downstream data. This "semantic drift" compromises data reproducibility and governance, and impairs the utility of services like retrieval-augmented generation (RAG) and text-to-SQL systems. To address this, a novel framework is proposed for the automated extraction of fine-grained schema lineage from multilingual enterprise pipeline scripts. This method identifies four key components: source schemas, source tables, transformation logic, and aggregation operations, creating a standardized representation of data transformations. For the rigorous evaluation of lineage quality, this paper introduces the Schema Lineage Composite Evaluation (SLiCE), a metric that assesses both structural correctness and semantic fidelity. A new benchmark is also presented, comprising 1,700 manually annotated lineages from real-world industrial scripts. Experiments were conducted with 12 language models, from 1.3B to 32B small language models (SLMs) to large language models (LLMs) like GPT-4o and GPT-4.1. The results demonstrate that the performance of schema lineage extraction scales with model size and the sophistication of prompting techniques. Specially, a 32B open-source model, using a single reasoning trace, can achieve performance comparable to the GPT series under standard prompting. This finding suggests a scalable and economical approach for deploying schema-aware agents in practical applications.

W e present a novel approach for enhancing the resolution and geometric fidelity of 3D Gaussian Splatting (3DGS) beyond native training resolution. Current 3DGS methods are fundamentally limited by their input resolution, producing reconstructions that cannot extrapolate finer details than are present in the training views. Our work breaks this limitation through a lightweight generative model that predicts and refines additional 3D Gaussians where needed most. The key innovation is our Hessian-assisted sampling strategy, which intelligently identifies regions that are likely to benefit from densification, ensuring computational efficiency. Unlike computationally intensive GANs or diffusion approaches, our method operates in real-time ( 0.015s per inference on a single consumer-grade GPU), making it practical for interactive applications. Comprehensive experiments demonstrate significant improvements in both geometric accuracy and rendering quality compared to state-of-the-art methods, establishing a new paradigm for resolution-free 3D scene enhancement.

We introduce EvoGit, a decentralized multi-agent framework for collaborative software development driven by autonomous code evolution. EvoGit deploys a population of independent coding agents, each proposing edits to a shared code-base without centralized coordination, explicit message passing, or shared memory. Instead, all coordination emerges through a Git-based phylogenetic graph that tracks the full version lineage and enables agents to asynchronously read from and write to the evolving code repository. This graph-based structure supports fine-grained branching, implicit concurrency, and scalable agent interaction while preserving a consistent historical record. Human involvement is minimal but strategic: users define high-level goals, periodically review the graph, and provide lightweight feedback to promote promising directions or prune unproductive ones. Experiments demonstrate EvoGit's ability to autonomously produce functional and modular software artifacts across two real-world tasks: (1) building a web application from scratch using modern frameworks, and (2) constructing a meta-level system that evolves its own language-model-guided solver for the bin-packing optimization problem. Our results underscore EvoGit's potential to establish a new paradigm for decentralized, automated, and continual software development. Large language models (LLMs) have significantly advanced the automation of software development, excelling at tasks such as code generation, debugging, and documentation Zhao et al. (2023); Minaee et al. (2024); Y ang et al. (2024a); Team et al. (2023); OpenAI et al. (2024). Building upon this foundation, recent efforts have embedded LLMs into autonomous coding agents Qian et al. (2023); Y ang et al. (2024b); Hong et al. (2024); Islam et al. (2024), enabling the execution of multi-step development workflows through tool usage, memory, and interaction policies Y ao et al. (2023); Xi et al. (2023); Wang et al. (2024). While promising, current frameworks face critical limitations. Most rely on scalar reward signals, ground-truth unit tests, or dense human feedback to supervise agent behavior. These assumptions are ill-suited for open-ended software engineering, where success criteria are emergent and multifaceted. Furthermore, agent collaboration is typically centralized and synchronous, requiring a global orchestrator and shared memory, which restricts scalability and robustness. Critically, the development process often lacks traceability: as code branches diverge and recombine, it becomes increasingly difficult to understand the provenance of design decisions or to reproduce successful outcomes.

The COVID-19 pandemic, caused by SARS-CoV-2, highlighted the critical need for accurate prediction of disease severity to optimize healthcare resource allocation and patient management. The spike protein, which facilitates viral entry into host cells, exhibits high mutation rates, particularly in the receptor-binding domain, influencing viral pathogenicity. Artificial intelligence approaches, such as deep learning, offer promising solutions for leveraging genomic and clinical data to predict disease outcomes. Objective: This study aimed to develop a hybrid CNN-LSTM deep learning model to predict COVID-19 severity using spike protein sequences and associated clinical metadata from South American patients. Methods: We retrieved 9,570 spike protein sequences from the GISAID database, of which 3,467 met inclusion criteria after standardization. The dataset included 2,313 severe and 1,154 mild cases. A feature engineering pipeline extracted features from sequences, while demographic and clinical variables were one-hot encoded. A hybrid CNN-LSTM architecture was trained, combining CNN layers for local pattern extraction and an LSTM layer for long-term dependency modeling. Results: The model achieved an F1 score of 82.92%, ROC-AUC of 0.9084, precision of 83.56%, and recall of 82.85%, demonstrating robust classification performance. Training stabilized at 85% accuracy with minimal overfitting. The most prevalent lineages (P.1, AY.99.2) and clades (GR, GK) aligned with regional epidemiological trends, suggesting potential associations between viral genetics and clinical outcomes. Conclusion: The CNN-LSTM hybrid model effectively predicted COVID-19 severity using spike protein sequences and clinical data, highlighting the utility of AI in genomic surveillance and precision public health. Despite limitations, this approach provides a framework for early severity prediction in future outbreaks.

Time-resolved single-cell omics data offers high-throughput, genome-wide measurements of cellular states, which are instrumental to reverse-engineer the processes underpinning cell fate. Such technologies are inherently destructive, allowing only cross-sectional measurements of the underlying stochastic dynamical system. Furthermore, cells may divide or die in addition to changing their molecular state. Collectively these present a major challenge to inferring realistic biophysical models. We present a novel approach, \emph{unbalanced} probability flow inference, that addresses this challenge for biological processes modelled as stochastic dynamics with growth. By leveraging a Lagrangian formulation of the Fokker-Planck equation, our method accurately disentangles drift from intrinsic noise and growth. We showcase the applicability of our approach through evaluation on a range of simulated and real single-cell RNA-seq datasets. Comparing to several existing methods, we find our method achieves higher accuracy while enjoying a simple two-step training scheme.