Juan Carlos Izpisua Belmonte Believes Aging May Come Down to a Cell's Identity Crisis Follow this author to personalize your feed and get instant alerts. Follow Go to your personalized feed WHY FOLLOW? Smart Alerts: Get notified about major news as it happens. For decades, Juan Carlos Izpisua Belmonte focused on unlocking the secrets of human life at its earliest stages. A pioneer in developmental biology and a long-time professor at the Salk Institute, he used Shinya Yamanaka's game-changing discovery of four genes that can essentially rewind the clock--turning adult cells to a younger state--to better understand how a fertilized egg turns into a human. Izpisua Belmonte's groundbreaking studies include creating the first embryo containing both human and monkey cells in 2021 to better study the steps that occur well before birth.

Data and finance professionals are competing in Excel obstacle courses--amassing huge followings and keeping the Microsoft program relevant. For many people, Microsoft Excel is to be avoided at all costs. Maybe you lied about being "proficient" with the spreadsheet program to pad out your résumé and have lived in fear of being found out ever since. Or it could be that you do have a grasp on a few basic formulas but find the interface too labyrinthine to truly master. Still, like it or not, Excel remains an integral part of businesses, with Microsoft claiming "hundreds of millions" of users worldwide.

Plus: Space data centers don't exist yet, but people already oppose them. Supercooled kidneys have been transplanted into pigs in a "landmark achievement" When it comes to organ donation, time is everything. As soon as an organ has been removed from a donor's body, it starts to deteriorate. Surgeons have only a matter of hours to get it into a recipient. In most cases, organs will be kept on ice during that time, at around 4 C (39 F). They cannot be frozen--in previous attempts, ice has formed, causing all kinds of damage.

Large language models (LLMs) have achieved significant performance progress in various natural language processing applications. However, LLMs still struggle to meet the strict requirements for accuracy and reliability in the medical field and face many challenges in clinical applications. Existing clinical diagnostic evaluation benchmarks for evaluating medical agents powered by LLMs have severe limitations. Firstly, most existing medical evaluation benchmarks face the risk of data leakage or contamination.

Yet, training still treats these logits in isolation--either supervising only the final, highest-resolution logits or applying deep supervision with identical loss weights at every scale--without exploring mixed-scale combinations. Consequently, the decoder output misses the complementary cues that arise only when coarse and fine predictions are fused. To address this issue, we introduce LoMix (Logits Mixing), a Neural Architecture Search (NAS)-inspired, differentiable plug-and-play module that generates new mixed-scale outputs and learns how exactly each of them should guide the training process. More precisely, LoMix mixes the multi-scale decoder logits with four lightweight fusion operators: addition, multiplication, concatenation, and attentionbased weighted fusion, yielding a rich set of synthetic "mutant" maps. Every original or mutant map is given a softplus loss weight that is co-optimized with network parameters, mimicking a one-step architecture search that automatically discovers the most useful scales, mixtures, and operators. Plugging LoMix into recent U-shaped architectures (i.e., PVT-V2-B2 backbone with EMCAD decoder) on Synapse 8-organ dataset improves DICE by +4.2% over single-output supervision, +2.2% over deep supervision, and +1.5% over equally weighted additive fusion, all with zero inference overhead. When training data are scarce (e.g., one or two labeled scans, 5% of the trainset), the advantage grows to +9.23%, underscoring LoMix's data efficiency. Across four benchmarks and diverse U-shaped networks, LoMiX improves DICE by up to +13.5% over single-output supervision, confirming that learnable weighted mixed-scale fusion generalizes broadly while remaining data efficient, fully interpretable, and overhead-free at inference. Our implementation is available at https://github.com/SLDGroup/LoMix.

A.1 Proof of Monotonicity and Submodularity In Equation (3a), we stated the objective of the knapsack cover to be Remark 1. f+M is monotonically increasing. A.2 Knapsack Cover To find a solution to problem 3, we use the greedy algorithm proposed by Badanidiyuru and Vondrák [2], which deals with submodular maximization subject to a system of lknapsack constraints and with pmatroid constraints. We present an adapted version of the algorithm in Algorithm 2 where l = 1. Theparameter allows us to 16 trade-off solution time and solution quality. In this work, we set = 0.2.

With the demand for human donor organs desperately outstripping supply, scientists are working to see if genetically edited pig organs can bridge the gap. Leonardo Riella, medical director for kidney transplantation at Massachusetts General Hospital, checks on Tim Andrews after his pig kidney transplant. Surgeons at Massachusetts General Hospital have removed a genetically engineered pig kidney from a 67-year-old New Hampshire man after a period of decreasing kidney function, the hospital confirmed to WIRED in a statement. The organ functioned for nearly nine months, longer than previous pig organ transplants, before it was removed on October 23. Tim Andrews received the pig kidney on January 25 after being on dialysis for more than two years due to end-stage kidney disease.

The non-invasive assessment of increasingly incidentally discovered renal masses is a critical challenge in urologic oncology, where diagnostic uncertainty frequently leads to the overtreatment of benign or indolent tumors. In this study, we developed and validated RenalCLIP using a dataset of 27,866 CT scans from 8,809 patients across nine Chinese medical centers and the public TCIA cohort, a visual-language foundation model for characterization, diagnosis and prognosis of renal mass. The model was developed via a two-stage pre-training strategy that first enhances the image and text encoders with domain-specific knowledge before aligning them through a contrastive learning objective, to create robust representations for superior generalization and diagnostic precision. RenalCLIP achieved better performance and superior generalizability across 10 core tasks spanning the full clinical workflow of kidney cancer, including anatomical assessment, diagnostic classification, and survival prediction, compared with other state-of-the-art general-purpose CT foundation models. Especially, for complicated task like recurrence-free survival prediction in the TCIA cohort, RenalCLIP achieved a C-index of 0.726, representing a substantial improvement of approximately 20% over the leading baselines. Furthermore, RenalCLIP's pre-training imparted remarkable data efficiency; in the diagnostic classification task, it only needs 20% training data to achieve the peak performance of all baseline models even after they were fully fine-tuned on 100% of the data. Additionally, it achieved superior performance in report generation, image-text retrieval and zero-shot diagnosis tasks. Our findings establish that RenalCLIP provides a robust tool with the potential to enhance diagnostic accuracy, refine prognostic stratification, and personalize the management of patients with kidney cancer.