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Accurately quantifying motor characteristics in Parkinson disease (PD) is crucial for monitoring disease progression and optimizing treatment strategies. The finger-tapping test is a standard motor assessment. Clinicians visually evaluate a patient's tapping performance and assign an overall severity score based on tapping amplitude, speed, and irregularity. However, this subjective evaluation is prone to inter- and intra-rater variability, and does not offer insights into individual motor characteristics captured during this test. This paper introduces a granular computer vision-based method for quantifying PD motor characteristics from video recordings. Four sets of clinically relevant features are proposed to characterize hypokinesia, bradykinesia, sequence effect, and hesitation-halts. We evaluate our approach on video recordings and clinical evaluations of 74 PD patients from the Personalized Parkinson Project. Principal component analysis with varimax rotation shows that the video-based features corresponded to the four deficits. Additionally, video-based analysis has allowed us to identify further granular distinctions within sequence effect and hesitation-halts deficits. In the following, we have used these features to train machine learning classifiers to estimate the Movement Disorder Society Unified Parkinson Disease Rating Scale (MDS-UPDRS) finger-tapping score. Compared to state-of-the-art approaches, our method achieves a higher accuracy in MDS-UPDRS score prediction, while still providing an interpretable quantification of individual finger-tapping motor characteristics. In summary, the proposed framework provides a practical solution for the objective assessment of PD motor characteristics, that can potentially be applied in both clinical and remote settings. Future work is needed to assess its responsiveness to symptomatic treatment and disease progression.

Foundation models refer to architectures trained on vast datasets using autoregressive pre-training from natural language processing to capture intricate patterns and motifs. They were originally developed to transfer such learned knowledge to downstream predictive tasks. Recently, however, some studies repurpose these learned representations for phenotype discovery without rigorous validation, risking superficially realistic but clinically incoherent embeddings. To test this mismatch, we trained two autoregressive models -- a sequence-to-sequence LSTM and a reduced Transformer -- on longitudinal ART for HIV and Acute Hypotension datasets. Controlled irregularity was added during training via random inter-visit gaps, while test sequences stayed complete. Patient-trajectory synthesis evaluated distributional and correlational fidelity. Both reproduced feature distributions but failed to preserve cross-feature structure -- showing that generative pre-training yields local realism but limited clinical coherence. These results highlight the need for domain-specific evaluation and support trajectory synthesis as a practical probe before fine-tuning or deployment.

Time series data in real-world applications such as healthcare, climate modeling, and finance are often irregular, multimodal, and messy, with varying sampling rates, asynchronous modalities, and pervasive missingness. However, existing benchmarks typically assume clean, regularly sampled, unimodal data, creating a significant gap between research and real-world deployment. We introduce Time-IMM, a dataset specifically designed to capture cause-driven irregularity in multimodal multivariate time series. Time-IMM represents nine distinct types of time series irregularity, categorized into trigger-based, constraint-based, and artifact-based mechanisms. Complementing the dataset, we introduce IMM-TSF, a benchmark library for forecasting on irregular multimodal time series, enabling asynchronous integration and realistic evaluation. IMM-TSF includes specialized fusion modules, including a timestamp-to-text fusion module and a multimodality fusion module, which support both recency-aware averaging and attention-based integration strategies. Empirical results demonstrate that explicitly modeling multimodality on irregular time series data leads to substantial gains in forecasting performance. Time-IMM and IMM-TSF provide a foundation for advancing time series analysis under real-world conditions. The dataset is publicly available at https://github.com/blacksnail789521/Time-IMM, and the benchmark library can be accessed at https://github.com/blacksnail789521/IMM-TSF. Project page: https://blacksnail789521.github.io/time-imm-project-page/

A trivial example of an equivalence relation is equality ( =). More useful examples in the context of ICA are equivalence up to permutation, rescaling, or scalar transformation. Defining an appropriate equivalence class for the problem at hand therefore allows us to specify exactly the type of indeterminancies which cannot be resolved and up to which the true generative process can be recovered.

The numeral systems of Indo-Aryan languages such as Hindi, Gujarati, and Bengali are highly unusual in that unlike most numeral systems (e.g., those of English, Chinese, etc.), forms referring to 1--99 are highly non-transparent and are cannot be constructed using straightforward rules. As an example, Hindi/Urdu *ikyānve* `91' is not decomposable into the composite elements *ek* `one' and *nave* `ninety' in the way that its English counterpart is. This paper situates Indo-Aryan languages within the typology of cross-linguistic numeral systems, and explores the linguistic and non-linguistic factors that may be responsible for the persistence of complex systems in these languages. Using cross-linguistic data from multiple databases, we develop and employ a number of cross-linguistically applicable metrics to quantifies the complexity of languages' numeral systems, and demonstrate that Indo-Aryan languages have decisively more complex numeral systems than the world's languages as a whole, though individual Indo-Aryan languages differ from each other in terms of the complexity of the patterns they display. We investigate the factors (e.g., religion, geographic isolation, etc.) that underlie complexity in numeral systems, with a focus on South Asia, in an attempt to develop an account of why complex numeral systems developed and persisted in certain Indo-Aryan languages but not elsewhere. Finally, we demonstrate that Indo-Aryan numeral systems adhere to certain general pressures toward efficient communication found cross-linguistically, despite their high complexity. We call for this somewhat overlooked dimension of complexity to be taken seriously when discussing general variation in cross-linguistic numeral systems.

Orthographic transparency -- how directly spelling is related to sound -- lacks a unified, script-agnostic metric. Using ideas from algorithmic information theory, we quantify orthographic transparency in terms of the mutual compressibility between orthographic and phonological strings. Our measure provides a principled way to combine two factors that decrease orthographic transparency, capturing both irregular spellings and rule complexity in one quantity. We estimate our transparency measure using prequential code-lengths derived from neural sequence models. Evaluating 22 languages across a broad range of script types (alphabetic, abjad, abugida, syllabic, logographic) confirms common intuitions about relative transparency of scripts. Mutual compressibility offers a simple, principled, and general yardstick for orthographic transparency.

Lameness and gait irregularities are significant concerns in equine health management, affecting performance, welfare, and economic value. Traditional observational methods rely on subjective expert assessments, which can lead to inconsistencies in detecting subtle or early-stage lameness. While AI-based approaches have emerged, many require multiple sensors, force plates, or video systems, making them costly and impractical for field deployment. In this applied research study, we present a stride-level classification system that utilizes a single inertial measurement unit (IMU) and a one-dimensional convolutional neural network (1D CNN) to objectively differentiate between sound and lame horses, with a primary focus on the trot gait. The proposed system was tested under real-world conditions, achieving a 90% session-level accuracy with no false positives, demonstrating its robustness for practical applications. By employing a single, non-intrusive, and readily available sensor, our approach significantly reduces the complexity and cost of hardware requirements while maintaining high classification performance. These results highlight the potential of our CNN-based method as a field-tested, scalable solution for automated lameness detection. By enabling early diagnosis, this system offers a valuable tool for preventing minor gait irregularities from developing into severe conditions, ultimately contributing to improved equine welfare and performance in veterinary and equestrian practice.