AI model from Google's DeepMind reads recipe for life in DNA An AI model developed by Google's DeepMind could transform our understanding of DNA - the complete recipe for building and running the human body - and its impact on disease and medicine discovery, according to researchers. Called AlphaGenome, the model could help scientists discover why subtle differences in our DNA put us at risk of conditions such as high blood pressure, dementia and obesity. It could also dramatically accelerate our understanding of genetic diseases and cancer. The developers of the model acknowledge it's not perfect, but experts have described it as an incredible feat and a major milestone. We see AlphaGenome as a tool for understanding what the functional elements in the genome do, which we hope will accelerate our fundamental understanding of the code of life, says Natasha Latysheva, research engineer at DeepMind.

We greatly thank the reviewers for their constructive comments. However, in certain applications, there is scientific evidence for a parametric form of the triggering kernel (e.g., [Beggs We show here a small example with 5 nodes in Figure 1. We have similar observations for recovering other edges in this example. In each picture, the two blue curves outline the proposed CIs, and the two red curves outline the asymptotic CI. Moreover, we will adjust Section 2-3 as suggested.

Soft growing robots, commonly referred to as vine robots, have demonstrated remarkable ability to interact safely and robustly with unstructured and dynamic environments. It is therefore natural to exploit contact with the environment for planning and design optimization tasks. Previous research has focused on planning under contact for passively deforming robots with pre-formed bends. However, adding active steering to these soft growing robots is necessary for successful navigation in more complex environments. To this end, we develop a unified modeling framework that integrates vine robot growth, bending, actuation, and obstacle contact. We extend the beam moment model to include the effects of actuation on kinematics under growth and then use these models to develop a fast parallel simulation framework. We validate our model and simulator with real robot experiments. To showcase the capabilities of our framework, we apply our model in a design optimization task to find designs for vine robots navigating through cluttered environments, identifying designs that minimize the number of required actuators by exploiting environmental contacts. We show the robustness of the designs to environmental and manufacturing uncertainties. Finally, we fabricate an optimized design and successfully deploy it in an obstacle-rich environment.

We thank all the reviewers for their efforts and constructive comments, which help improve the quality of our paper. Based on the analysis of the first and second moment of the estimator presented in Theorems 5.1 and 5.2, a Chebyshev's type error bound can be easily [obtained:] We will present it as a corollary in the final version. We will add this discussion to the final version. Better figure representing MSE vs p. Thanks for the suggestion and we will revise our paper accordingly. It shows that RMSE decreases as p increases.

This paper focuses on how to make a growing Vine robot steer in different directions with a novel approach to real-time steering control by autonomously applying adhesive tape to induce a surface wrinkles. This enabling real-time directional control with arbitrary many turns while maintaining the robot's soft structure. This system feeds growing material external to the tube. The design achieves fixed-angle turns in 2D space. Through experimental validation, we demonstrate repeated 21-degree turns using a Dubins path planner with minimal error, establishing a foundation for more versatile Vine robot applications. This approach combines real-time control, multi-degree-of-freedom steering, and structural flexibility, addressing key challenges in soft robotics.

Representation learning produces models in different domains, such as store purchases, client transactions, and general people's behaviour. However, such models for sequential data usually process a single sequence, ignoring context from other relevant ones, even in domains with rapidly changing external environments like finance or misguiding the prediction for a user with no recent events. We are the first to propose a method that aggregates information from multiple user representations augmenting a specific user one for a scenario of multiple co-occurring event sequences. Our study considers diverse aggregation approaches, ranging from simple pooling techniques to trainable attention-based approaches, especially Kernel attention aggregation, that can highlight more complex information flow from other users. The proposed method operates atop an existing encoder and supports its efficient fine-tuning. Across considered datasets of financial transactions and downstream tasks, Kernel attention improves ROC AUC scores, both with and without fine-tuning, while mean pooling yields a smaller but still significant gain.

This paper extends previous work on modeling network interactions with multivariate Hawkes processes by introducing a time-varying network into the model. For example, when one Twitter user publishes a tweet, followers of that user are likely to retweet in response. The dynamic network is intended to capture the creation of new connections, for example, when one Twitter user begins to follow another. The instantaneous network is represented by a binary adjacency matrix, and edges are added to the network according to a survival process with a event-driven rate. If one user frequently retweets another user's messages, then it is likely they will begin to follow that user and thereby add a new connection to the network.

Soft-growing robots (i.e., vine robots) are a promising class of soft robots that allow for navigation and growth in tightly confined environments. However, these robots remain challenging to model and control due to the complex interplay of the inflated structure and inextensible materials, which leads to obstacles for autonomous operation and design optimization. Although there exist simulators for these systems that have achieved qualitative and quantitative success in matching high-level behavior, they still often fail to capture realistic vine robot shapes using simplified parameter models and have difficulties in high-throughput simulation necessary for planning and parameter optimization. We propose a differentiable simulator for these systems, enabling the use of the simulator "in-the-loop" of gradient-based optimization approaches to address the issues listed above. With the more complex parameter fitting made possible by this approach, we experimentally validate and integrate a closed-form nonlinear stiffness model for thin-walled inflated tubes based on a first-principles approach to local material wrinkling. Our simulator also takes advantage of data-parallel operations by leveraging existing differentiable computation frameworks, allowing multiple simultaneous rollouts. We demonstrate the feasibility of using a physics-grounded nonlinear stiffness model within our simulator, and how it can be an effective tool in sim-to-real transfer. We provide our implementation open source.

Despite a significant proportion of the Earth being covered in water, exploration of what lies below has been limited due to the challenges and difficulties inherent in the process. Current state of the art robots such as Remotely Operated Vehicles (ROVs) and Autonomous Underwater Vehicles (AUVs) are bulky, rigid and unable to conform to their environment. Soft robotics offers solutions to this issue. Fluid-actuated eversion or growing robots, in particular, are a good example. While current eversion robots have found many applications on land, their inherent properties make them particularly well suited to underwater environments. An important factor when considering underwater eversion robots is the establishment of a suitable steering mechanism that can enable the robot to change direction as required. This project proposes a design for an eversion robot that is capable of steering while underwater, through the use of bending pouches, a design commonly seen in the literature on land-based eversion robots. These bending pouches contract to enable directional change. Similar to their land-based counterparts, the underwater eversion robot uses the same fluid in the medium it operates in to achieve extension and bending but also to additionally aid in neutral buoyancy. The actuation method of bending pouches meant that robots needed to fully extend before steering was possible. Three robots, with the same design and dimensions were constructed from polyethylene tubes and tested. Our research shows that although the soft eversion robot design in this paper was not capable of consistently generating the same amounts of bending for the inflation volume, it still achieved suitable bending at a range of inflation volumes and was observed to bend to a maximum angle of 68 degrees at 2000 ml, which is in line with the bending angles reported for land-based eversion robots in the literature.