Food insecurity remains a persistent public health emergency in the United States, tightly interwoven with chronic disease, mental illness, and opioid misuse. Yet despite the existence of thousands of food banks and pantries, access remains fragmented: 1) current retrieval systems depend on static directories or generic search engines, which provide incomplete and geographically irrelevant results; 2) LLM-based chatbots offer only vague nutritional suggestions and fail to adapt to real-world constraints such as time, mobility, and transportation; and 3) existing food recommendation systems optimize for culinary diversity but overlook survival-critical needs of food-insecure populations, including immediate proximity, verified availability, and contextual barriers. These limitations risk leaving the most vulnerable individuals, those experiencing homelessness, addiction, or digital illiteracy, unable to access urgently needed resources. To address this, we introduce Food4All, the first multi-agent framework explicitly designed for real-time, context-aware free food retrieval. Food4All unifies three innovations: 1) heterogeneous data aggregation across official databases, community platforms, and social media to provide a continuously updated pool of food resources; 2) a lightweight reinforcement learning algorithm trained on curated cases to optimize for both geographic accessibility and nutritional correctness; and 3) an online feedback loop that dynamically adapts retrieval policies to evolving user needs. By bridging information acquisition, semantic analysis, and decision support, Food4All delivers nutritionally annotated and guidance at the point of need. This framework establishes an urgent step toward scalable, equitable, and intelligent systems that directly support populations facing food insecurity and its compounding health risks.

Managing physiological variables within clinically safe target zones is a central challenge in healthcare, particularly for chronic conditions such as Type 1 Diabetes Mellitus (T1DM). Reinforcement learning (RL) offers promise for personalising treatment, but struggles with the delayed and heterogeneous effects of interventions. We propose a novel RL framework to study and support decision-making in T1DM technologies, such as automated insulin delivery. Our approach captures the complex temporal dynamics of treatment by unifying two control modalities: \textit{impulse control} for discrete, fast-acting interventions (e.g., insulin boluses), and \textit{switching control} for longer-acting treatments and regime shifts. The core of our method is a constrained Markov decision process augmented with physiological state features, enabling safe policy learning under clinical and resource constraints. The framework incorporates biologically realistic factors, including insulin decay, leading to policies that better reflect real-world therapeutic behaviour. While not intended for clinical deployment, this work establishes a foundation for future safe and temporally-aware RL in healthcare. We provide theoretical guarantees of convergence and demonstrate empirical improvements in a stylised T1DM control task, reducing blood glucose level violations from 22.4\% (state-of-the-art) to as low as 10.8\%.

The search for evidence of past life on Mars presents a tremendous challenge that requires the usage of very advanced robotic technologies to overcome it. Current digital microscopic imagers and spectrometers used for astrobiological examination suffer from limitations such as insufficient resolution, narrow detection range, and lack of portability. To overcome these challenges, this research study presents modifications to the Phoenix rover to expand its capability for detecting biosignatures on Mars. This paper examines the modifications implemented on the Phoenix rover to enhance its capability to detect a broader spectrum of biosignatures. One of the notable improvements comprises the integration of advanced digital microscopic imagers and spectrometers, enabling high-resolution examination of soil samples. Additionally, the mechanical components of the device have been reinforced to enhance maneuverability and optimize subsurface sampling capabilities. Empirical investigations have demonstrated that Phoenix has the capability to navigate diverse geological environments and procure samples for the purpose of biomolecular analysis. The biomolecular instrumentation and hybrid analytical methods showcased in this study demonstrate considerable potential for future astrobiology missions on Mars. The potential for enhancing the system lies in the possibility of broadening the range of detectable biomarkers and biosignatures.

Accurate nutrition estimation helps people make informed decisions about their dietary choices and is crucial for preventing serious health issues. We present NutriBench, the first publicly available natural language meal description based nutrition benchmark. NutriBench consists of 5,000 human-verified meal descriptions with macro-nutrient labels, including carbohydrates, proteins, fats, and calories. The data is divided into 15 subsets varying in complexity based on the number, servings, and popularity of the food items in the meal and the specificity of serving size descriptions. We conducted an extensive evaluation of seven popular and state-of-the-art Large Language Models (LLMs), including GPT-3.5, Llama-3, and a medical domain-specific model with standard, Chain-of-Thought and Retrieval-Augmented Generation strategies on our benchmark for carbohydrate estimation. We also conducted a human study involving expert and non-expert participants and found that LLMs can provide more accurate and faster predictions over a range of complex queries. We present a thorough analysis and comparison of different LLMs, highlighting the opportunities and challenges of using LLMs for nutrition estimation in real-life scenarios. Our benchmark is publicly available at: https://mehak126.github.io/nutribench.html

Not so long ago, the professional cycling world's approach to fuelling was remarkably basic. Options for riders barely extended beyond a monotonous menu of pasta, rice or whatever fare that night's hotel kitchen decided to serve up. These days, it is an entirely different prospect, with vast sums spent on custom-built food trucks, personalised nutrition apps and meticulously-planned meal regimes all in the name of performance enhancement. For the nutritionists and chefs tasked with providing sustenance to power their team's riders over 2,170 miles in the coming weeks there are principally two dilemmas: what food to prepare and how to do so in an ever-changing environment. The answers are gleaned from a year-round process that begins in December during pre-season training.

Calculating mealtime insulin doses poses a significant challenge for individuals with Type 1 Diabetes (T1D). Doses should perfectly compensate for expected post-meal glucose excursions, requiring a profound understanding of the individual's insulin sensitivity and the meal macronutrients'. Usually, people rely on intuition and experience to develop this understanding. In this work, we demonstrate how a reinforcement learning agent, employing a self-attention encoder network, can effectively mimic and enhance this intuitive process. Trained on 80 virtual subjects from the FDA-approved UVA/Padova T1D adult cohort and tested on twenty, self-attention demonstrates superior performance compared to other network architectures. Results reveal a significant reduction in glycemic risk, from 16.5 to 9.6 in scenarios using sensor-augmented pump and from 9.1 to 6.7 in scenarios using automated insulin delivery. This new paradigm bypasses conventional therapy parameters, offering the potential to simplify treatment and promising improved quality of life and glycemic outcomes for people with T1D.

Hybrid models composing mechanistic ODE-based dynamics with flexible and expressive neural network components have grown rapidly in popularity, especially in scientific domains where such ODE-based modeling offers important interpretability and validated causal grounding (e.g., for counterfactual reasoning). The incorporation of mechanistic models also provides inductive bias in standard blackbox modeling approaches, critical when learning from small datasets or partially observed, complex systems. Unfortunately, as the hybrid models become more flexible, the causal grounding provided by the mechanistic model can quickly be lost. We address this problem by leveraging another common source of domain knowledge: \emph{ranking} of treatment effects for a set of interventions, even if the precise treatment effect is unknown. We encode this information in a \emph{causal loss} that we combine with the standard predictive loss to arrive at a \emph{hybrid loss} that biases our learning towards causally valid hybrid models. We demonstrate our ability to achieve a win-win, state-of-the-art predictive performance \emph{and} causal validity, in the challenging task of modeling glucose dynamics post-exercise in individuals with type 1 diabetes.

In the dynamic field of nuclear magnetic resonance (NMR) spectroscopy, artificial intelligence (AI) has ushered in a transformative era for molecular studies. AI-driven NMR prediction, powered by advanced machine learning and predictive algorithms, has fundamentally reshaped the interpretation of NMR spectra. This innovation empowers us to forecast spectral patterns swiftly and accurately across a broad spectrum of molecular structures. Furthermore, the advent of generative modeling offers a groundbreaking approach, making it feasible to make informed prediction of 2D NMR from chemical language (such as SMILES, IUPAC Name). Our method mirrors the multifaceted nature of NMR imaging experiments, producing 2D NMRs for the same molecule based on different conditions, such as solvents and temperatures. Our methodology is versatile, catering to both monosaccharide-derived small molecules, oligosaccharides and large polysaccharides. A deeper exploration of the discrepancies in these predictions can provide insights into the influence of elements such as functional groups, repeating units, and the modification of the monomers on the outcomes. Given the complex nature involved in the generation of 2D NMRs, our objective is to fully leverage the potential of AI to enhance the precision, efficiency, and comprehensibility of NMR spectral analysis, ultimately advancing both the field of NMR spectroscopy and the broader realm of molecular research.

Molecular representation learning (MRL) is a powerful tool for bridging the gap between machine learning and chemical sciences, as it converts molecules into numerical representations while preserving their chemical features. These encoded representations serve as a foundation for various downstream biochemical studies, including property prediction and drug design. MRL has had great success with proteins and general biomolecule datasets. Yet, in the growing sub-field of glycoscience (the study of carbohydrates, where longer carbohydrates are also called glycans), MRL methods have been barely explored. This under-exploration can be primarily attributed to the limited availability of comprehensive and well-curated carbohydrate-specific datasets and a lack of Machine learning (ML) pipelines specifically tailored to meet the unique problems presented by carbohydrate data. Since interpreting and annotating carbohydrate-specific data is generally more complicated than protein data, domain experts are usually required to get involved. The existing MRL methods, predominately optimized for proteins and small biomolecules, also cannot be directly used in carbohydrate applications without special modifications. To address this challenge, accelerate progress in glycoscience, and enrich the data resources of the MRL community, we introduce GlycoNMR. GlycoNMR contains two laboriously curated datasets with 2,609 carbohydrate structures and 211,543 annotated nuclear magnetic resonance (NMR) chemical shifts for precise atomic-level prediction. We tailored carbohydrate-specific features and adapted existing MRL models to tackle this problem effectively. For illustration, we benchmark four modified MRL models on our new datasets.

Carbohydrates, vital components of biological systems, are well-known for their structural diversity. Nuclear Magnetic Resonance (NMR) spectroscopy plays a crucial role in understanding their intricate molecular arrangements and is essential in assessing and verifying the molecular structure of organic molecules. An important part of this process is to predict the NMR chemical shift from the molecular structure. This work introduces a novel approach that leverages E(3) equivariant graph neural networks to predict carbohydrate NMR spectra. Notably, our model achieves a substantial reduction in mean absolute error, up to threefold, compared to traditional models that rely solely on two-dimensional molecular structure. Even with limited data, the model excels, highlighting its robustness and generalization capabilities. The implications are far-reaching and go beyond an advanced understanding of carbohydrate structures and spectral interpretation. For example, it could accelerate research in pharmaceutical applications, biochemistry, and structural biology, offering a faster and more reliable analysis of molecular structures. Furthermore, our approach is a key step towards a new data-driven era in spectroscopy, potentially influencing spectroscopic techniques beyond NMR.