Juan Carlos Izpisua Belmonte Believes Aging May Come Down to a Cell's Identity Crisis Follow this author to personalize your feed and get instant alerts. Follow Go to your personalized feed WHY FOLLOW? Smart Alerts: Get notified about major news as it happens. For decades, Juan Carlos Izpisua Belmonte focused on unlocking the secrets of human life at its earliest stages. A pioneer in developmental biology and a long-time professor at the Salk Institute, he used Shinya Yamanaka's game-changing discovery of four genes that can essentially rewind the clock--turning adult cells to a younger state--to better understand how a fertilized egg turns into a human. Izpisua Belmonte's groundbreaking studies include creating the first embryo containing both human and monkey cells in 2021 to better study the steps that occur well before birth.

However, most existing optimizers stop searching the parameter space once they reach a local minimum. Given the complex geometric properties of the loss landscape, it is difficult to guarantee that such a point is the lowest or provides the best generalization. To address this, we propose an adaptor "E" for gradient-based optimizers. The adapted optimizer tends to continue exploring along landscape 5.0 valleys (areas with low and nearly identical losses) in order to search for potentially1.0

While humans effortlessly draw visual objects and shapes by adaptively allocating attention based on their complexity, existing multimodal large language models (MLLMs) remain constrained by rigid token representations. Bridging this gap, we propose ALTo, an adaptive length tokenizer for autoregressive mask generation. To achieve this, a novel token length predictor is designed, along with a length regularization term and a differentiable token chunking strategy.

Estimating the homography between two images is crucial for mid-or high-level vision tasks, such as image stitching and fusion. However, using supervised learning methods is often challenging or costly due to the difficulty of collecting ground-truth data. In response, unsupervised learning approaches have emerged. Most early methods, though, assume that the given image pairs are from the same camera or have minor lighting differences. Consequently, while these methods perform effectively under such conditions, they generally fail when input image pairs come from different domains, referred to as multimodal image pairs.To address these limitations, we propose AltO, an unsupervised learning framework for estimating homography in multimodal image pairs. Our method employs a two-phase alternating optimization framework, similar to Expectation-Maximization (EM), where one phase reduces the geometry gap and the other addresses the modality gap. To handle these gaps, we use Barlow Twins loss for the modality gap and propose an extended version, Geometry Barlow Twins, for the geometry gap. As a result, we demonstrate that our method, AltO, can be trained on multimodal datasets without any ground-truth data. It not only outperforms other unsupervised methods but is also compatible with various architectures of homography estimators.The source code can be found at: https://github.com/songsang7/AltO

In response, unsupervised learning approaches have emerged.

Estimating the homography between two images is crucial for mid- or high-level vision tasks, such as image stitching and fusion. However, using supervised learning methods is often challenging or costly due to the difficulty of collecting ground-truth data. In response, unsupervised learning approaches have emerged. Most early methods, though, assume that the given image pairs are from the same camera or have minor lighting differences. Consequently, while these methods perform effectively under such conditions, they generally fail when input image pairs come from different domains, referred to as multimodal image pairs.To address these limitations, we propose AltO, an unsupervised learning framework for estimating homography in multimodal image pairs. Our method employs a two-phase alternating optimization framework, similar to Expectation-Maximization (EM), where one phase reduces the geometry gap and the other addresses the modality gap.

Estimating the homography between two images is crucial for mid- or high-level vision tasks, such as image stitching and fusion. However, using supervised learning methods is often challenging or costly due to the difficulty of collecting ground-truth data. In response, unsupervised learning approaches have emerged. Most early methods, though, assume that the given image pairs are from the same camera or have minor lighting differences. Consequently, while these methods perform effectively under such conditions, they generally fail when input image pairs come from different domains, referred to as multimodal image pairs. To address these limitations, we propose AltO, an unsupervised learning framework for estimating homography in multimodal image pairs. Our method employs a two-phase alternating optimization framework, similar to Expectation-Maximization (EM), where one phase reduces the geometry gap and the other addresses the modality gap. To handle these gaps, we use Barlow Twins loss for the modality gap and propose an extended version, Geometry Barlow Twins, for the geometry gap. As a result, we demonstrate that our method, AltO, can be trained on multimodal datasets without any ground-truth data. It not only outperforms other unsupervised methods but is also compatible with various architectures of homography estimators. The source code can be found at:~\url{https://github.com/songsang7/AltO}

In the early 1970s, programming computers involved punching holes in cards and feeding them to room-size machines that would produce results through a line printer, often hours or even days later. This is what computing had looked like for a long time, and it was against this backdrop that a team of 29 scientists and researchers at the famed Xerox PARC created the more intimate form of computing we know today: one with a display, a keyboard, and a mouse. This computer, called Alto, was so bewilderingly different that it necessitated a new term: interactive computing. Alto was viewed by some as absurdly extravagant because of its expensive components. But fast-forward 50 years, and multitrillion-dollar supply chains have sprung up to transform silica-rich sands into sophisticated, wondrous computers that live in our pockets.

We present ALTO, a network orchestrator for efficiently serving compound AI systems such as pipelines of language models. ALTO achieves high throughput and low latency by taking advantage of an optimization opportunity specific to generative language models: streaming intermediate outputs. As language models produce outputs token by token, ALTO exposes opportunities to stream intermediate outputs between stages when possible. We highlight two new challenges of correctness and load balancing which emerge when streaming intermediate data across distributed pipeline stage instances. We also motivate the need for an aggregation-aware routing interface and distributed prompt-aware scheduling to address these challenges. We demonstrate the impact of ALTO's partial output streaming on a complex chatbot verification pipeline, increasing throughput by up to 3x for a fixed latency target of 4 seconds / request while also reducing tail latency by 1.8x compared to a baseline serving approach.